GENE EXPRESSION PROFILING ON SIV-INFECTED SOOTY MANGABEYS AND RHESUS MACAQUES

感染 SIV 的乌白眉猴和恒河猴的基因表达谱分析

• 批准号: 7958386
• 负责人: Amitinder Kaur
• 金额: $ 19.97万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958386
• 关键词: Acquired Immunodeficiency Syndrome; Biopsy; Cercocebus atys; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Expression; Genes; Grant; Infection; Institution; Macaca mulatta; Microarray Analysis; Molecular Profiling; New England; Peripheral; Primates; Research; Research Personnel; Resources; SIV; Source; Tissues; United States National Institutes of Health; base; insight; lymph nodes; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this study is to use gene expression analysis to determine the profile of host genes thjat are differentially expressed after SIV infection in a natural host that does not develop AIDS, as compared to a non-natural host that progresses to AIDS. Peripheral lymph node biopsy tissue before and two weeks after SIVsmE041 infection in four sooty mangabeys and four rhesus macaques is being subjected to microarray analysis. Early differences in host gene expression in response to SIV in the two species should provide valuable insight into mechanisms of protection against AIDS in natural hosts.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的总体目的是使用基因表达分析来确定宿主基因的谱图在SIV感染后，在天然宿主中与不发展AIDS的天然宿主相比，与发展为AIDS的非天然宿主相比。 SIVSME041感染前和两周后的四个烟熏芒果和四个恒河猕猴在SIVSME041感染之前和两周后进行了周围淋巴结活检组织。 宿主基因表达的早期差异响应于两个物种的SIV响应，应为对自然寄主的艾滋病的保护机​​制提供宝贵的见解。