System for documenting and tracking skin lesions

用于记录和跟踪皮肤病变的系统

• 批准号: 10484160
• 负责人: MEHRAN ARMAND
• 金额: $ 25.24万
• 依托单位: LUMO IMAGING LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10484160
• 关键词: Address; Affect; Agreement; Algorithms; American; Appearance; Area; Atopic Dermatitis; Awareness; Basal Cell; Body Surface; Body Weight Changes; Cancerous; Caring; Cessation of life; Clinical; Clinical Research; Computer software; Consumption; Cutaneous; Data; Death Rate; Dermatologic; Dermatologist; Dermoscopy; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Documentation; Early Diagnosis; Eczema; Evolution; Future; Goals; Health Expenditures; Health Services Accessibility; Healthcare Systems; Image; Imaging Techniques; Incidence; Inflammatory; Institutional Review Boards; Lead; Lesion; Light; Literature; Location; Longitudinal Studies; Malignant Neoplasms; Manuals; Monitor; Morphology; Participant; Pathologist; Patient Monitoring; Patients; Persons; Phase; Photography; Pigments; Procedures; Prognosis; Psoriasis; Reading; Resolution; Scanning; Screening for Skin Cancer; Screening procedure; Sensitivity and Specificity; Skin; Skin Cancer; Small Business Technology Transfer Research; Software Tools; Squamous cell carcinoma; Standardization; System; Tablets; Techniques; Technology; Telephone; Testing; Time; Treatment Cost; Treatment Efficacy; United States; Visual; Visualization; Wait Time; Work; base; cancer diagnosis; cancer type; clinical imaging; cost; high risk; improved; interest; melanoma; mortality; new growth; novel; outpatient facility; patient prognosis; point of care; primary care setting; prototype; screening; screening program; skin lesion; standard of care; teledermatology; tool; underserved community; virtual

Project Summary The objective of this STTR proposal is to develop a system for longitudinally tracking the locations and morphologic changes to all Pigmented Skin Lesions on the patient’s body. The proposed software will build on a previously developed Total Body Photography (TBP) system, called Lumo Scanner, that can provide unprecedented resolution across the entire body surface. Skin cancers, including both melanoma and non- melanoma, are the most common type of cancer in the United States. Early-stage identification of suspicious pigmented lesions (SPLs) in primary care settings can lead to improved melanoma prognosis and a possible 20- fold reduction in treatment cost. The proposed device significantly reduces the clinicians’ time required for documenting lesions and for making diagnostic decisions, thereby allowing the healthcare system to better cope with the forecasted shortages of dermatologists. The proposed technology is novel in that it: 1) provides a standardized way of referring to lesions’ locations, 2) allows dermatologists to maintain a complete historical record of every lesion 3) detect significantly changed (evolved) lesions and 4) assists dermatologists in finding cancerous lesions at their very early stages to improve overall patient prognosis. The project team has already developed a Total Body Photography (TBP) system that is unlike the commercially available systems in that it obviates the need for using a dermatoscope and can produce images of sufficient resolution that can be used for early detection of skin cancers. This device has already received an IRB and has been installed at Johns Hopkins (JHU) Outpatient Center for its first clinical study. By your reading of this proposal is under review, JHU’s 100-patient study in which the efficacy of scan-based examinations will be compared with the efficacy of traditional clinical and dermatoscopic-based skin examinations, is well on its way. Within this proposal team intends to develop a temporal study tool that can follow all PSLs over time regardless of participants’ pose and weight changes between scanning sessions. Such a system will enable clinicians to accurately monitor patients’ PSLs over time, document any changes in previously identified lesions, and detect new lesions at the point of care. Within, the two phases of this project, the team will also focus on detecting evolved lesions and optimizing the scanning software to provide a better user interface for following and diagnosing pigmented skin lesions (PSL) while reducing the amount of time it takes for the dermatologist to fully document the patients lesions of interest. Though some literature suggests the epidemy in melanoma is the result of over-screening as evidenced by the number of deaths not increasing commensurately, others suggest that the low death-rate is the result of better screening. Regardless, there is unanimous agreement that too many lesions are studied by pathologists. Lumo Scanner when combined with the facilities developed in this project, will enable technicians perform highly accurate scans and thus allow the dermatologist to spend less documenting the high-risk patients. Also, this novel device will enable teledermatology in areas where there is a scarcity of dermatologists. Additionally, the proposed device can also be used for diagnosing and accurately monitoring the efficacy of therapies for psoriasis, atopic dermatitis, and other inflammatory skin conditions. Psoriasis and atopic dermatitis are also serious global problems. In the United States, psoriasis affects about 8 million people while about 31.6 million people in the United States have some form of eczema, including atopic dermatitis.

项目概要 该 STTR 提案的目标是开发一个用于纵向跟踪位置和信息的系统。 所提议的软件将建立在患者身体上所有色素性皮肤病变的形态变化之上。 先前开发的全身摄影 (TBP) 系统，称为 Lumo 扫描仪，可以提供 整个身体表面的皮肤癌（包括黑色素瘤和非黑色素瘤）得到前所未有的解决。 黑色素瘤是美国最常见的可疑癌症类型。 初级保健机构中的色素性病变 (SPL) 可改善黑色素瘤预后，并可能 20- 所提议的设备显着减少了主教治疗所需的时间。 记录病变并做出诊断决策，从而使医疗保健系统能够更好地应对 所提出的技术的新颖之处在于：1）提供了 参考病变位置的标准化方法，2) 允许皮肤科医生保持完整的历史记录 记录每个病变 3) 检测显着变化（进化）的病变 4) 协助皮肤科医生发现 在极早期阶段发现癌症病变，以改善患者的整体预后。 该项目团队已经开发出一种全身摄影（TBP）系统，该系统与商业上的不同 可用的系统，因为它消除了使用皮肤镜的需要，并且可以产生足够的图像 该设备已获得 IRB 和可用于早期检测皮肤癌的分辨率。 已安装在约翰·霍普金斯 (JHU) 门诊中心进行首次临床研究。 提案正在审查中，JHU 的 100 名患者研究中基于扫描的检查的功效将 与传统临床和基于皮肤镜的皮肤检查的功效相比，该方法正在取得进展。 在这个提案中，团队打算开发一个时间研究工具，可以随着时间的推移跟踪所有 PSL，无论 这样的系统将使信徒能够了解参与者的姿势和体重在扫描过程中的变化。 随着时间的推移，准确监测患者的 PSL，记录先前识别的病变的任何变化，并检测 在该项目的两个阶段中，团队还将重点检测护理点的新病变。 病变不断发展并优化扫描软件，为跟踪和扫描提供更好的用户界面 诊断色素性皮肤病变 (PSL)，同时减少皮肤科医生完全诊断所需的时间 记录感兴趣的患者病变。 尽管一些文献表明黑色素瘤的流行是过度筛查的结果，正如 死亡人数没有相应增加，其他人则认为低死亡率是由于更好的结果 不管怎样，人们一致认为 Lumo 研究了太多的病变。 扫描仪与该项目中开发的设施相结合，将使技术人员能够执行 准确的扫描，从而使皮肤科医生能够减少记录高风险患者的费用。 新颖的设备将使皮肤科医生稀缺的地区能够进行远程皮肤病治疗。 所提出的设备还可用于诊断和准确监测治疗效果 牛皮癣、特应性皮炎和其他炎症性皮肤病也属于牛皮癣和特应性皮炎。 在美国，银屑病影响着大约 800 万人，而大约 3160 万人受到银屑病的影响。 在美国，人们患有某种形式的湿疹，包括特应性皮炎。