HORMONAL EFFECTS ON BEHAVIOR AND SPINAL CORD MORPHOLOGY

荷尔蒙对行为和脊髓形态的影响

• 批准号: 2266915
• 负责人: S MARC BREEDLOVE
• 金额: $ 17.1万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2266915
• 关键词: NMDA receptors; androgens; denervation; hormone regulation /control mechanism; laboratory rat; male; neural plasticity; neuroendocrine system; neuromuscular function; penis erection; psychomotor function; spinal nerves

DESCRIPTION (Adapted from applicant's abstract): Five experiments are proposed. These will determine whether neurons in the brain that project to the spinal nucleus of the bulbo cavernousus muscle (SNB) can accumulate androgen and whether androgen can still exert its morphological effects if these afferents are transsected or if androgen is applied locally in the spinal cord. In Experiment 4, rats that are functionally mosaic for androgen sensitivity will be created to determine whether SNB neurons themselves must be androgen sensitive to undergo morphological alteration. The fifth experiment will examine whether the target muscle affects the efficiency of androgen responsiveness in motoneurons by monitoring testosterone accumulation following axotomy, reinnervation of native muscle, and cross innervation of foreign muscle. In specific aim 2, four experiments will determine how testosterone stimulation of the bulbocavernosus alters SNB dendrites. The role of sensory afferents, axonal transport or neural activity in the motoneuron, and neurotrophic factors will be investigated. In specific aim 3, two additional experiments are proposed: one to examine the role of local NMDA receptors mediate the morphological changes in SNB and a second to examine the role of copulatory experience.

描述（改编自申请人的摘要）：五个实验 建议的。 这些将决定大脑中的神经元是否投射 球海绵体肌 (SNB) 的脊髓核可以 雄激素蓄积以及雄激素是否还能发挥作用 如果这些传入神经被横断或雄激素会产生形态学影响 局部应用于脊髓。 实验 4 中，大鼠 将创建雄激素敏感性的功能嵌合体 确定 SNB 神经元本身是否必须对雄激素敏感 发生形态改变。 第五个实验将检验 目标肌肉是否影响雄激素的效率 通过监测睾酮积累来提高运动神经元的反应性 轴索切除术后，原生肌肉的神经支配和交叉神经支配 外来肌肉。 在具体目标 2 中，四个实验将确定 睾酮刺激球海绵体肌如何改变 SNB 树突。 感觉传入、轴突运输或神经的作用 运动神经元的活动和神经营养因子将 调查了。 在具体目标 3 中，另外两个实验是 提出：一是检查局部 NMDA 受体介导的作用 SNB 的形态变化和第二个检查的作用 交配经历。