Yale Clinical and Translational Science Award

耶鲁临床与转化科学奖

• 批准号: 10369090
• 负责人: John H. Krystal
• 金额: $ 1051.12万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369090
• 关键词: Address; Area; Beds; Bioethics; Bioinformatics; Biometry; Catchment Area; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Connecticut; County; Data; Electronic Health Record; Environment; Ethics; Faculty; Family; Fellowship Program; Fostering; Functional disorder; Funding; Future; Generations; Genomics; Grant; Growth; Health; Health system; Healthcare; Healthcare Systems; Heart; Home; Hospitals; Image; Imprisonment; Improve Access; Industry; Informatics; Infrastructure; Interdisciplinary Study; International; Intervention; Investments; Learning; Link; Methodology; Mission; NCI Scholars Program; Outpatients; Patients; Pilot Projects; Public Health; Public Health Informatics; Randomized; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rhode Island; Role; Science; Scientific Advances and Accomplishments; Scientist; Shapes; Site; Special Population; Talents; Technology; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Visit; Wood material; actionable mutation; base; bioimaging; career; career development; clinical care; clinical center; clinical investigation; community based research; data resource; exome sequencing; health care disparity; informatics infrastructure; innovation; insight; member; multiple omics; new technology; next generation; novel; patient population; personalized health care; personalized medicine; point of care; post-doctoral training; pre-doctoral; programs; recruit; research and development; translational impact; translational pipeline; translational scientist

Contact PD/PI: Smith, Brian Richard 1. Overall: Project Summary The Yale Center for Clinical Investigation (YCCI) was created in 2005 to advance Yale's clinical research mission. One year later, YCCI became the home of the Yale CTSA. At YCCIs inception, Yale was a national leader in T0-T2 translational research, basic/translational science training, and it supported distinctive fellowship programs such as the Robert Wood Johnson Clinical Scholars Program. Since then, the CTSA has had a transformative impact linking diverse components of the Yale community in T1-T4 research, providing the central infrastructure for the effective conduct of ethical, innovative, rigorous, and reproducible research, and in training the next generation of research leaders. By any metric of scale, breadth, quality, and impact, both the CTSA's research enterprise and its educational mission have been enormously successful for Yale. This renewal application does not simply seek to maintain excellence, but to enable YCCI to drive the continued transformation of the Yale T1-T4 translational research mission and its predoctoral and postdoctoral training mission and to promote collaboration across CTSA hubs. First, it will support informatics and computational advances that drive the emergence of a learning health system. In so doing, it will draw on the Yale New Haven Health System, a six-hospital 2,681-bed consortium that provides more than 2.4 million outpatient visits from patients from upper Westchester county, throughout Connecticut, and southern Rhode Island. It will also prepare young scientists to draw on this infrastructure to conduct research that influences the future of healthcare. Second, it will support technological and scientific advances in areas that will support the emergence of personalized healthcare, including multi-omics and imaging. YCCI will provide pilot grant support and training to foster the development of research careers and research teams that can deepen our insights into pathophysiology and build toward personalized treatments. Third, it will engage a broader and more diverse group of faculty, trainees, and community representatives to collaborate in the mission of addressing healthcare disparities that constitute a major burden on patients, their families, and on public health. To support this mission, YCCI will also foster the development of careers in community-based research from a diverse group of young investigators and enhance the overall clinical research workforce. Project Summary/Abstract Page 177 Contact PD/PI: Smith, Brian Richard # ! ! % "# # " ! "#! !# ! & # # ! $ " ! " ! ! # ) # # % !" $ # " # # #! # ! ! # ! # #! " # " % ! # ! ' " % !" #(*" $#"# # $ # " # % ! # & # # "#! # & % # ("# # ! # ! # "("# # # ! " # $ # " & & ! & # # ! " # "# ! # $!# ! ! &# $ # " !( # " % % # % ! # % ! " # " "#! # " ! " " ! % # "# " # ! $# " # # # ! & ! ! "$ #" ! # # $ # " # ! # "("#

联系人 PD/PI：Smith、Brian Richard 1. 总体：项目概要 耶鲁大学临床研究中心 (YCCI) 成立于 2005 年，旨在推进耶鲁大学的临床研究 使命。一年后，YCCI 成为耶鲁大学 CTSA 所在地。在 YCCI 成立之初，耶鲁大学是一所全国性大学 T0-T2 转化研究、基础/转化科学培训领域的领导者，并支持独特的 奖学金计划，例如罗伯特·伍德·约翰逊临床学者计划。从那时起，CTSA 在 T1-T4 研究中将耶鲁大学社区的不同组成部分联系起来具有变革性的影响，提供 有效进行道德、创新、严格和可重复研究的中央基础设施， 以及培训下一代研究领导者。无论以规模、广度、质量和影响力来衡量， CTSA 的研究事业及其教育使命为耶鲁大学带来了巨大的成功。 此次更新申请不仅仅是为了保持卓越，而是为了让 YCCI 能够推动 耶鲁大学T1-T4转化研究任务及其博士前和博士后的持续转型 培训任务并促进 CTSA 中心之间的合作。首先，它将支持信息学和 计算的进步推动了学习健康系统的出现。在此过程中，它将借鉴 耶鲁纽黑文医疗系统是一个拥有 6 家医院、2,681 个床位的联合体，提供超过 240 万次医疗服务 来自上韦斯特切斯特县、整个康涅狄格州和罗德岛南部的患者的门诊就诊 岛。它还将使年轻科学家做好准备，利用这一基础设施进行影响科学的研究。 医疗保健的未来。其次，它将支持支持领域的技术和科学进步。 个性化医疗保健的出现，包括多组学和成像。 YCCI将提供试点补助支持 以及促进研究事业和研究团队发展的培训，从而加深我们的见解 进入病理生理学并建立个性化治疗。第三，它将吸引更广泛、更广泛的 不同群体的教师、学员和社区代表在解决问题的使命中进行合作 医疗保健差异对患者及其家人和公共卫生构成重大负担。到 为了支持这一使命，YCCI 还将促进社区研究事业的发展 多元化的年轻研究人员群体并增强整体临床研究队伍。 项目摘要/摘要第 177 页 联系人 PD/PI：Smith、Brian Richard #！ ！ %“##”！ “#!#!&##!$” ！ “！！#）##%！” $ # "###!#!!#!# #！ “#”%！ #！ ” “%！” #(*" $#"# # $# “#%！#&##”#！ # & % # ("##!#!# "("# # # ! " # $ # " & & ! & # # ! " # "# !# $!# !! &# $ # " !( # " % % # % ! # % ! " # " "#! # " ! " " ！ %#“#”#！ $# " # # # !& !! "$ #" ! # # $ # " # ! # "("#