Pain and Neurodegenerative Undergraduate Research Experiences: Interacting with community partners to build specialized and enhanced neurologic disease programs for undergraduates.

疼痛和神经退行性本科生研究经验：与社区合作伙伴互动，为本科生建立专门和增强的神经系统疾病项目。

• 批准号: 10318168
• 负责人: MICHAEL CASCIO
• 金额: $ 10.8万
• 依托单位: DUQUESNE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10318168
• 关键词: Affect; Age; Area; Atmosphere; Attitude; Basic Science; Biochemistry; Biology; Biomedical Engineering; Biomedical Research; Budgets; Chemistry; Chronic; Climate; Clinic; Clinical; Clinical Research; Communities; Country; Data; Development; Disease; Educational workshop; Empathy; Ensure; Ethics; Exposure to; First Generation College Students; Funding; Generations; Goals; Hispanic-serving Institution; Historically Black Colleges and Universities; Individual; Institution; Interview; Journals; Nerve Degeneration; Neurodegenerative Disorders; Neurology; Neurosciences; Occupational Therapy; Oral; Pain; Pain Research; Patients; Pharmacology; Pharmacy facility; Physical therapy; Physicians; Physics; Population; Population Heterogeneity; Process; Productivity; Psychology; Public Health; Research; Research Personnel; Safety; Science; Scientist; Site; Student recruitment; Students; Time; Training; Travel; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Universities; Visit; Work; Writing; career; career development; chronic neurologic disease; chronic pain; chronic pain management; chronic pain patient; chronic painful condition; computer science; curriculum development; design; experience; improved; interest; member; nervous system disorder; programs; recruit; sequence learning; summer program; summer research; symposium; undergraduate research experience; undergraduate student

PROJECT SUMMARY In the last decade, due to Congressional budget cuts, NIH funding for biomedical research has plummeted despite a growing public health need. Beyond the obvious effect of this reduction on the productivity of research labs, this funding climate likely dissuades undergraduate students from pursuing careers in biomedical research. This effect will be particularly deleterious to the study and understanding of chronic neurologic disease, an area of growing concern. We aim to counteract this possibility by supporting specialized summer undergraduate research experiences in pain and neurodegenerative disease. The rationale for this proposal is that by strengthening undergraduate research programs in neurologic disease, we can begin to build a pipeline of skilled researchers to respond to increasing rates of neurodegenerative diseases as our population ages. This proposal aims to develop and continue to implement two synergistic biomedical research programs. These new programs, the Pain Undergraduate Research Experience (PURE) and Neurodegenerative Undergraduate Research Experience (NURE), are cross-disciplinary and community- engaged biomedical summer undergraduate research programs. The objective of the PURE and NURE summer program is to increase student understanding of and exposure to the underlying science of pain and neurodegeneration, and importantly, to offer a more complete and authentic experience, by bridging basic science research with opportunities for students to interact on- and off-site with clinical researchers. 12 (six per program) rising sophomores and above will be recruited each summer for a 10-week long PURE or NURE session. We anticipate recruiting students from a variety of undergraduate majors including biology, chemistry, biochemistry, pre-physical therapy, pre-occupational therapy, pre-pharmacy, neuroscience, physics, computer science, and biomedical engineering. [We aim to include a diverse population of students by recruiting nationally from large research universities, historically black colleges and universities, Hispanic-serving institutions, and regionally from low research and primarily undergraduate institutions.]

项目概要 过去十年，由于国会预算削减，NIH 用于生物医学研究的经费直线下降 尽管公共卫生需求不断增长。除了这种减少对生产力的明显影响之外 研究实验室，这种资助氛围可能会阻碍本科生从事以下领域的职业： 生物医学研究。这种效应对于慢性病的研究和理解尤其有害。 神经系统疾病，一个日益受到关注的领域。我们的目标是通过支持专门的 疼痛和神经退行性疾病的暑期本科生研究经历。这样做的理由 建议通过加强神经系统疾病的本科生研究项目，我们可以开始 建立一支熟练的研究人员队伍，以应对不断增加的神经退行性疾病发病率 人口年龄。该提案旨在发展并继续实施两项协同生物医学研究 程序。这些新项目、疼痛本科生研究体验 (PURE) 和 神经退行性本科生研究经验（NURE）是跨学科和社区的 从事生物医学暑期本科研究项目。 PURE 和 NURE 的目标 暑期课程旨在提高学生对疼痛和疼痛的基础科学的理解和接触 神经退行性变，重要的是，通过桥接基本的神经退行性疾病，提供更完整和真实的体验 科学研究为学生提供与临床研究人员进行现场和场外互动的机会。 12（每 6 个 计划）每年夏天都会招募大二及以上学生参加为期 10 周的 PURE 或 NURE 会议。我们预计招收来自各种本科专业的学生，​​包括生物学、化学、 生物化学、物理治疗预科、职业治疗预科、药学预科、神经科学、物理、计算机 科学和生物医学工程。 [我们的目标是通过招募多元化的学生群体 全国范围内的大型研究型大学、历史悠久的黑人学院和大学、西班牙裔服务 机构，以及区域性的低研究机构和主要是本科机构。]

项目成果

Cyanobacterial extract with serotonin receptor subtype 7 (5-HT7 R) affinity modulates depression and anxiety-like behavior in mice.

具有血清素受体亚型 7 (5-HT7 R) 亲和力的蓝藻提取物可调节小鼠的抑郁和焦虑样行为。

• 发表时间: 2018
• 作者: Lax, Neil C;Parker, Stacy;Hilton, Edward J;Seliman, Youstina;Tidgewell, Kevin J;Kolber, Benedict J
• 通讯作者: Kolber, Benedict J

Modeling Neural Behavior and Pain During Bladder Distention using an Agent-based Model of the Central Nucleus of the Amygdala.

使用基于代理的杏仁核中央核模型对膀胱扩张期间的神经行为和疼痛进行建模。

• 发表时间: 2019
• 作者: Baktay, Joshua;Neilan, Rachael Miller;Behun, Marissa;McQuaid, Neal;Kolber, Benedict
• 通讯作者: Kolber, Benedict

Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels.

源自人脑内皮细胞系的细胞外囊泡可提高细胞 ATP 水平。

• 发表时间: 2021-01-03
• 影响因子: 3.3
• 作者: Dave, Kandarp M;Zhao, Wanzhu;Hoover, Catherine;D'Souza, Anisha;S Manickam, Devika
• 通讯作者: S Manickam, Devika

Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures.

含有线粒体的细胞外囊泡 (EV) 可以减少小鼠脑梗塞的面积，EV/HSP27 可以保护缺血的脑内皮培养物。

• DOI: 10.1016/j.jconrel.2023.01.025
• 发表时间: 2023-01-12
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: K;arp M. Dave;arp;D. Stolz;V. Venna;Victoria A. Quaicoe;Michael E. Maniskas;Michael Reynolds;Riyan Babidhan;Duncan X. Dobbins;Maura N. Farinelli;Abigail Sullivan;Tarun N. Bhatia;Hannah Yankello;Rohan Reddy;Y. Bae;R. Leak;S. Shiva;L. McCullough;D. Manickam
• 通讯作者: D. Manickam