CONSORTIUM: SUNY-STONY BROOK

联盟：纽约州立大学-石溪分校

• 批准号: 7927138
• 负责人: John B. Reinitz
• 金额: $ 13.3万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7927138
• 关键词: Behavior; Biology; Chemistry; Chicago; Communities; Complement; Development; Developmental Biology; Education; Evolution; Faculty; Genomics; Goals; Institutes; Institution; Investigation; Lead; Leadership; Maps; Modeling; Performance; Physics; Physiological; Physiology; Research; Research Infrastructure; Role; Stress; Structure-Activity Relationship; Systems Biology; Time; Universities; cluster computing; flexibility; network models; new technology; outreach; pressure; programs

We propose to develop a Center for Systems Biology to promote interdisciplinary scientific investigation and education in Chicago. Faculty in the Institute for Genomics and Systems Biology at the University of Chicago will take a leadership role and together with collaborators at other Chicago institutions will create a broad outreach to the community. The Centers scientific program will focus on the robustness of transcriptional networks in physiological, developmental and evolutionary time scales. We propose to go beyond mapping Network topologies to develop dynamical models of the behavior of transcriptional regulatory networks during physiological stress, during cellular and organismal development, and during the evolution of species. These goals will be achieved by bringing together experts in genomics, developmental biology, evolutionary biology, stress and physiology, network modeling, high performance and grid computing, chemistry, and physics. The overarching aim of the Centers research is to uncover the organizational principles that transcriptional regulatory networks share as they respond to physiological, development and evolutionary inputs and pressures. These principles are expected to reveal structure-function relationships in networks that lead to physiological and evolutionary robustness or, its complement, flexibility.

我们建议开发一个系统生物学中心，以促进芝加哥的跨学科科学研究和教育。芝加哥大学基因组学和系统生物学研究所的教师将担任领导职务，并与其他芝加哥机构的合作者一起为社区提供广泛的宣传。中心科学计划将重点关注转录网络在生理，发育和进化时间尺度上的鲁棒性。我们建议超越映射网络拓扑，以开发生理压力，细胞和生物体发育以及物种进化过程中转录调节网络行为的动态模型。这些目标将通过将基因组学，发育生物学，进化生物学，压力和生理学，网络建模，高性能和网格计算，化学和物理学的专家汇集在一起​​。中心研究的总体目的是揭示转录监管网络对生理，发展和进化的投入和压力的反应时共享的组织原则。这些原则有望揭示网络中的结构 - 功能关系，从而导致生理和进化的鲁棒性，或者其补充，灵活性。