False Memories in Alzheimer's Disease

阿尔茨海默病的错误记忆

基本信息

批准号：
10292883
负责人：
Andrew Budson
金额：
--
依托单位：
VA BOSTON HEALTH CARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2023-06-30
项目状态：
已结题

项目摘要

Many Veterans with Alzheimer’s disease in the mild cognitive impairment and mild dementia stages live alone in the community. Although it has been known for over 100 years that forgetting interferes with their quality of life, we have obtained new data demonstrating that rates of false memories in those with AD are extremely high—almost as high as forgetting. The goal of this grant is to understand the physiological and cognitive basis of false memories and their clinical and functional implications in daily life. We need to understand to what degree false memories impact the daily life of patients with AD. We need to determine good models of false memories in the laboratory that correlate with false memories in the real world. We need to use those models to understand the cognitive and physiological bases of false memories, and to try out different strategies, aids, and techniques to reduce false memories. To accomplish these goals we plan to do the following studies. Experiment 1 will examine the correlation between false memories and forgetting (using standard and novel questionnaires) with activities of daily living and quality of life (using standard questionnaires) in patients with AD. Experiment 2 will examine the correlation between false memories in daily life (using a novel questionnaire) and several experimental false memory paradigms in patients with AD. Experiment 3 will use standard neuropsychological tests to examine the cognitive domains that underlie false memories in patients with AD. Experiment 4 will use novel behavioral experimental memory paradigms to examine the memory components that underlie false memories in patients with AD. Experiment 5 will use a novel event-related potential (ERP) false memory paradigm to examine the physiological basis of false memories in patients with AD. Once these goals have been accomplished, we will be ready to apply these methods to reduce false memories in the daily life of Veterans with AD. Our prior VA Merit research worked to better understand true and false memories of patients with AD in the laboratory. The present proposal builds on the prior work and takes a major step forward, aiming to understand how false memories in daily life relate to false memories in the laboratory, as well as to cognitive function, brain physiology, and—most importantly—quality of life. Once these relationships are understood, laboratory models of false memories can be utilized to rationally design interventions that can reduce false memories in the daily life patients with AD, improving quality of life for patients and their families.

许多患有阿尔茨海默病的退伍军人患有轻度损伤和轻度痴呆舞台独自生活在社区中，尽管人们已经知道 100 多年来，人们都忘记了这一点。干扰他们的生活质量，我们获得的新数据表明，错误率 AD 患者的记忆力非常强，几乎与遗忘一样高。是了解错误记忆的生理和认知基础及其临床和我们需要了解错误记忆对日常生活的影响程度。我们需要在 AD 患者的日常生活中确定错误记忆的良好模型。我们需要使用这些模型来与现实世界中的错误记忆相关联。了解错误记忆的认知和生理基础，并尝试不同的方法减少错误记忆的策略、辅助工具和技术。为了实现这些目标，我们计划进行以下实验 1 的研究。错误记忆和遗忘之间的相关性（使用标准和新颖的问卷） AD 患者的日常生活活动和生活质量（使用标准问卷）。实验2将检查日常生活中错误记忆之间的相关性（使用小说问卷）和 AD 患者的几个实验错误记忆范式。 3 将使用标准的神经心理学测试来检查错误背后的认知领域实验 4 将使用新的行为实验记忆。研究 AD 患者错误记忆背后的记忆成分的范例。实验 5 将使用一种新颖的事件相关电位 (ERP) 错误记忆范式来检查一旦这些目标实现，AD 患者错误记忆的生理基础。完成后，我们将准备好应用这些方法来减少日常生活中的错误记忆患有 A.D. 的退伍军人我们之前的 VA Merit 研究致力于更好地理解真实和错误的记忆目前的建议建立在之前的工作基础上，并以实验室中的 AD 患者为研究对象。向前迈进一步，旨在了解日常生活中的错误记忆与现实生活中的错误记忆有何关系实验室，以及认知功能、大脑生理学，以及最重要的生活质量。一旦理解了这些关系，错误记忆的实验室模型就可以用来合理设计干预措施，减少AD患者日常生活中的错误记忆，提高患者及其家人的生活质量。