IBR-COBRE Phase III

IBR-COBRE III期

基本信息

批准号：
10225594
负责人：
WILLIAM S WARD
金额：
$ 107.55万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-13 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225594
关键词：
Area Basic Science Biogenesis Bioinformatics Biomedical Research Burn injury CRISPR/Cas technology Cellular Immunology Center for Translational Science Activities Centers of Research Excellence Clinic Custom Developed Countries Development Developmental Biology Discipline of obstetrics Ensure Epigenetic Process Extramural Activities Faculty Fertility Fertilization in Vitro Funding Genes Germ Cells Goals Grant Gynecology Hawaii Human In Vitro Institutes International Intracytoplasmic Sperm Injections Investments Mentors Micromanipulation Molecular Immunology Mus Phase Physicians Pilot Projects Procedures Productivity Reproduction Reproductive Biology Reproductive Health Reproductive Technology Research Research Institute Research Personnel Research Priority Research Project Grants Safety Scientist Secure Series Services Stream System Teacher Professional Development Techniques Time Transgenic Mice Translational Research Translations United States National Academy of Sciences United States National Institutes of Health Universities Women&apos s Health arm base clinical application egg faculty mentor improved innovation instrumentation medical schools member novel operation organ growth overpopulation programs recruit sperm cell zygote

项目摘要

PROJECT SUMMARY/ABSTRACT – Overall Component Approximately 70,000 babies born in the U.S. in 2015 were conceived by artificial reproductive technologies (ART), which involves one of two techniques: in vitro fertilization (IVF) in which the sperm fertilizes the egg in vitro, or intracytoplasmic sperm injection (ICSI) in which the sperm is injected into the egg using micromanipulation. The rapid rise in ART world wide, and continued developments of the procedures employed by ART clinics, requires that research keeps pace to ensure the safety of ART and to improve reproductive health. Starting with just three faculty in 2000, with COBRE support starting in 2008, the IBR has grown to 14 full-time faculty in four departments, within the John A. Burns School of Medicine (JABSOM), of the University of Hawaii at Manoa (UHM). Of these 14, the COBRE Phases I and II supported 10, and all but two have obtained independent NIH R-series funding. The direct result of COBRE funding is that the IBR has emerged as an internationally recognized center of research excellence for reproductive biology and one of the best centers in the world for mouse gamete manipulation (ICSI and IVF). During Phase I, the IBR recruited five new faculty, establishing it as a reproductive biology research institute and attracting several national and international trainees. During Phase II, the Phase I project leaders became mentors and core directors while maintaining their own labs. Five additional faculty were recruited, bringing expertise in epigenetics, bioinformatics, gene editing and organ development, and we also established a close partnership with the Department of Obstetrics, Gynecology and Women's Health (Ob/Gyn). After ten years of support, the center is now competitive for several grant opportunities that we will pursue in Phase III. Phase III COBRE objective is to sustain the IBR COBRE as a world-class basic and translational science center of excellence in reproductive biology. This will be accomplished through two Specific Aims. Specific Aim 1: Expand and diversify the expertise of the COBRE research cores. Growing and diversifying the core user base, enhancing and streamlining core operations, and strengthening the core revenue streams will result in the sustainability of the cores and accelerate the pace of scientific discovery, heighten research productivity and increase competitiveness for extramural funding. Specific Aim 2: Develop and implement a Translational Pilot Project Program. We will leverage a strong partnership with the Dept. of Ob/Gyn to develop a new translational arm of research for the IBR. At the end of the Phase III COBRE, we envision that each of the cores will be fully or largely self-sustained, through a coordinated plan of recharge accounts, extramural grants, strategic investments and philanthropy, and that a the IBR will have successfully completed development of translational research arm through a novel implementation of the pilot projects program.

项目概要/摘要——整体组成 2015年美国约有7万名婴儿通过人工受孕出生技术 (ART)，涉及两种技术之一：体外受精 (IVF)，其中精子体外使卵子受精，或将精子注射到卵子中的胞浆内单精子注射 (ICSI) 使用显微操作在世界范围内迅速崛起，并且程序不断发展。受 ART 诊所雇用，要求研究保持同步，以确保 ART 的安全性并改进 2000 年，在 COBRE 的支持下，IBR 已拥有 3 名教职人员。约翰·A·伯恩斯医学院 (JABSOM) 的四个系的全职教职人员已增至 14 名在这 14 个项目中，COBRE 第一阶段和第二阶段支持了 10 个项目。其中两个获得了独立的 NIH R 系列资助。 COBRE 资助的直接结果是 IBR 获得了资助。成为国际公认的生殖生物学卓越研究中心和 IBR 招募了世界上最好的小鼠配子操作中心（ICSI 和 IVF）。五个新教师，将其建立为生殖生物学研究所，并吸引了数名国家和第二期项目负责人同时成为导师和核心负责人。又招募了五名教师来维护自己的实验室，带来表观遗传学方面的专业知识，我们还与生物信息学、基因编辑和器官发育等领域建立了密切的合作伙伴关系经过十年的支持，该中心成立了妇产科和妇女健康部（Ob/Gyn）。现在我们在第三阶段 COBRE 目标中寻求的几个资助机会具有竞争力。维持 IBR COBRE 作为世界级基础和转化科学卓越中心的地位这将通过两个具体目标 1 来实现：扩大和扩大。使 COBRE 研究核心的专业知识多样化扩大核心用户群并使之多样化，从而增强核心用户群。精简核心业务，加强核心收入来源将带来可持续性核心并加快科学发现的步伐，提高研究生产力并增加具体目标 2：制定并实施转化试点项目。我们将利用与妇产科的强大合作伙伴关系来开发一个新的转化部门。在第三阶段 COBRE 结束时，我们预计每个核心都将完全或已完成。通过补给账户、外部赠款、战略性资金的协调计划，在很大程度上是自我维持的投资和慈善事业，并且 IBR 将成功完成转化的开发研究部门通过一项新颖的试点项目计划实施。