2023 Cell Biology of Megakaryocytes and Platelets Gordon Research Conference and Gordon Research Seminar

2023巨核细胞和血小板细胞生物学戈登研究会议暨戈登研究研讨会

• 批准号: 10608747
• 负责人: ALESSANDRA BALDUINI
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608747
• 关键词: Academia; Address; Area; Basic Science; Biogenesis; Biology; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Bone Marrow; Cardiovascular Diseases; Cells; Cellular biology; Clinical; Coagulation Process; Collaborations; Communication; Complex; Congenital Disorders; Coupled; Data; Dedications; Development; Devices; Diagnosis; Disease; Disseminated Malignant Neoplasm; Engineering; Enhancers; Environment; Feedback; Fostering; Functional disorder; Future; Goals; Growth; Hematological Disease; Hematopoiesis; Hematopoietic stem cells; Hemorrhage; Hemostatic function; Immunity; Inflammation; Influentials; Inherited; International; Malignant Neoplasms; Megakaryocytes; Mentors; Mission; Molecular; Myeloproliferative disease; Neoplasm Metastasis; Outcome; Pathogenicity; Pathway interactions; Patients; Platelet Count measurement; Play; Prevention; Process; Production; Publications; Recording of previous events; Research; Research Personnel; Risk; Role; Signal Transduction; Stem Cell Development; Surface; Thrombopoiesis; Thrombopoietin; Thrombosis; Update; career; cell type; design; diagnostic tool; experience; hematopoietic stem cell differentiation; improved; leukemia; lymphatic development; meetings; mimetics; new technology; novel; novel therapeutics; platelet function; prevent; receptor function; seal; symposium; therapeutic target; tumor; wound healing

PROJECT SUMMARY / ABSTRACT The biennial Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on the Cell Biology of Megakaryocytes and Platelets brings together current leaders, junior investigators and trainees working on the development and disorders of the megakaryocyte lineage. It is the premier international meeting in the field. Our scientific mission is to bridge the gap between researchers working on different aspects of the lineage, i.e. hematopoietic stem cells, megakaryocytes and platelets. This mission is more relevant than ever, as the interdependence between each cell type becomes increasingly clear, e.g. the role of megakaryocytes in stem cell development, and the impact of inflammation on megakaryocyte growth and platelet production. The overarching, aim of the GRC is to allow current and emerging leaders of the field to communicate unpublished data, thereby educating colleagues, promoting discussions and fostering collaborations. Specifically, the aims are to: 1. Highlight the extraordinary progress being made in our understanding of platelet function in the context of hemostasis, thrombosis, and inherited/ congenital platelet disorders. Talks will cover the state-of-the-art on platelet surface receptor function and control of coagulation, intracellular signaling, the development of new targets for antiplatelet therapy, and immense progress in diagnosis and treatment of platelet function disorders. 2. Discuss the latest unpublished research on the engineering of devices and approaches to evaluate platelet function and how platelets can be used in therapy and as diagnostic tools. 3. Evaluate newly described mechanisms of megakaryocyte maturation and platelet production. It is increasingly apparent that platelet production is a complex multifactorial process controlled by super enhancers as well as the bone marrow microenvironment. In a dedicated session, we will discuss this unique interplay between the megakaryocyte lineage and other cells in the bone marrow environment. 4. Discuss studies that push the field into new directions, including updates on new regulators of hematopoiesis and thrombopoiesis, new technologies to study platelets on a single cell level and in high throughput functional omics, and a dedicated session to discuss newly identified critically influential roles for platelets in metastatic cancer, and megakaryocytes in leukemias and myeloproliferative disorders. To optimize interaction between researchers, and based on feedback from past conferences, we have designed most sessions so that they feature talks on both platelets and megakaryocytes. We also decided to continue with a new format that was first implemented in 2017, with the incorporation of 11 short talks to be selected from abstracts embedded within each of the main sessions (eliminating the dedicated hot topics session). The strengths of applying cross-disciplinary approaches to research questions will be emphasized throughout the whole meeting, and both basic science and translational aspects of the field will be discussed.

项目概要/摘要 两年一度的戈登细胞生物学研究会议（GRC）和戈登研究研讨会（GRS） 巨核细胞和血小板研究中心汇集了现任领导者、初级研究人员和受训人员，致力于研究 巨核细胞谱系的发育和紊乱。这是全球首屈一指的国际会议 场地。我们的科学使命是弥合不同领域研究人员之间的差距 谱系，即造血干细胞、巨核细胞和血小板。这一使命比以往任何时候都更加重要 随着每种细胞类型之间的相互依赖性变得越来越清晰，例如巨核细胞的作用 干细胞发育，以及炎症对巨核细胞生长和血小板生成的影响。这 GRC 的总体目标是让该领域的当前和新兴领导者能够进行未发表的交流 数据，从而教育同事、促进讨论和促进合作。 具体来说，目标是： 1. 强调我们在理解血小板功能方面所取得的非凡进展 止血、血栓形成和遗传/先天性血小板疾病。会谈将涵盖最先进的 血小板表面受体功能和凝血控制、细胞内信号传导、新药物的开发 抗血小板治疗的目标，以及血小板功能障碍的诊断和治疗方面的巨大进展。 2. 讨论有关评估血小板的设备和方法的工程的最新未发表的研究 功能以及血小板如何用于治疗和诊断工具。 3. 评估新描述的巨核细胞成熟和血小板产生的机制。这是 越来越明显的是，血小板的产生是一个由超级增强剂控制的复杂的多因素过程 还有骨髓微环境。在专门的会议中，我们将讨论这种独特的相互作用 巨核细胞谱系与骨髓环境中的其他细胞之间。 4. 讨论推动该领域进入新方向的研究，包括新监管机构的最新情况 造血和血小板生成，在单细胞水平和高水平上研究血小板的新技术 通量功能组学，以及专门的会议来讨论新确定的具有关键影响力的角色 转移性癌症中的血小板，以及白血病和骨髓增殖性疾病中的巨核细胞。 为了优化研究人员之间的互动，并根据过去会议的反馈，我们 大多数会议的设计都是以血小板和巨核细胞为主题。我们还决定 继续采用 2017 年首次实施的新形式，纳入 11 场简短演讲 从每个主要会议中嵌入的摘要中选择（消除专门的热点话题 会议）。将强调应用跨学科方法来解决研究问题的优势 在整个会议中，将讨论该领域的基础科学和转化方面。