2023 Liquid Crystals Gordon Research Conference & Gordon Research Seminar

2023年液晶戈登研究会议

• 批准号: 10683604
• 负责人: Cecilia Leal
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683604
• 关键词: 2019-nCoV; Academia; Address; Alzheimer' s Disease; Applied Research; Area; Basic Science; Biological; Biology; Biosensing Techniques; Biosensor; Birth; Capsid; Caring; Cell membrane; Chemistry; Collaborations; Colloids; Color; Communities; Complement 2; Detection; Diagnosis; Disease; Elastomers; Engineering; Environment; Equity; Faculty; Female; Fostering; Future; Goals; Hour; Human body; Implant; Industry; International; Joints; Leadership; Life; Lipids; Liquid substance; Medical; Membrane Lipids; Membrane Microdomains; Mentors; Military Personnel; Minority Groups; Minority Participation; Mission; Muscle; National Institute of Biomedical Imaging and Bioengineering; Nature; New Hampshire; Nucleic Acids; Oral; Participant; Pharmacologic Substance; Phase; Phase Transition; Physics; Play; Polymers; Postdoctoral Fellow; Prevention; Proteins; Reporting; Research; Research Personnel; Robotics; Role; Science; Scientist; Students; Suspensions; Technology; Toxin; Underrepresented Minority; United States National Institutes of Health; Universities; Viral; Virus; Voice; Water; Woman; active lifestyle; career; elastomeric; empowerment; experimental study; flexibility; liquid crystal; materials science; meetings; pathogen; peer; posters; prevent; self assembly; sensor; social; symposium; theories; tool

Project Summary Significance, timeliness and rationale. NIBIB's mission is to transform through engineering the understanding of disease and its prevention, detection, diagnosis, and treatment. Life would not be possible without liquid crystalline (LC) order. The most celebrated example is the unique combination of flexibility and confining ability of cell membranes which is possible because lipids cooperatively aggregate into a lamellar LC phase in water. The phase separation underlying the lipid raft paradigm of plasma membrane organization bears all the hall- marks of inter-LC phase transitions, as does separation in suspensions of amyloidogenic protein fibrils in Alz- heimer's disease. Many viruses, e.g., SARS-CoV-2, are enveloped in a lipid membrane and they may employ LC order for packing their nucleic acid cargo. Non-biological LCs have turned out to be sensitive in detecting and reporting on the presence of pathogens and toxins, making them highly interesting for autonomous bio- /chemosensors. LC formation is thus an integral component of what keeps us healthy and causes disease, and they are emerging as a powerful tool for detecting disease agents. Although this connection is known since long, it has until now been researched only marginally, constituting an under-explored opportunity in addressing soci- etal needs. Today, the international LC research community is undergoing a rebirth, fully embracing these as- pects. Interdisciplinary crossovers where LC science meets biological, life and pharmaceutical sciences, and engineering and materials science, play a groundbreaking role in leveraging the opportunities. Additional impact on the core fields of the NIH-NIBIB mission comes from, e.g., the exploration of LC elastomers in soft actuators or implants in the human body. Objective. The chairs seek support for the Gordon Research Conference (GRC) and Seminar (GRS) on Liquid Crystals 2023:“ From Nature to Transformational Technology through Liquid Crys- tal Science”, Southern New Hampshire University, Manchester, NH, June 24–25 (GRS), June 25-June 30 (GRC), 2023. The joint meetings will bring together US and international researchers at the forefront of today's vibrant LC science, spanning its full breadth and connecting academia, industry and military labs, young and senior, and harnessing every opportunity to promote women and underrepresented minorities as speakers, discussing lead- ers and participants. Approach. 30 prominent speakers have confirmed our invitations to present unpublished cutting-edge research, covering, e.g., LCs in and from nature, LC-self-assembly in colloids and polymers, and in emerging applications. 52% of speakers are female and 37% are non-white. Academic speakers are comple- mented by 2 industry and 2 military research lab speakers. Additionally, 5 speaker slots will be given to excellent young scientists selected from submitted poster abstracts. To further strengthen the voice of young researchers, the GRC is preceded by the GRS, catering only to students and post-docs and providing mentoring and career advice, and during the GRC, young scientists will be given precedence in all scientific discussions.

项目概要 重要性、及时性和基本原理 NIBIB 的使命是通过工程改变人们的理解。 疾病及其预防、检测、诊断和治疗如果没有液体，生命就不可能存在。 结晶（LC）顺序最著名的例子是灵活性和限制能力的独特结合。 这是可能的，因为脂质在水中协同聚集成层状液晶相。 质膜组织脂筏范式背后的相分离承担着所有的霍尔- LC 间相变的标记，以及 Alz- 中淀粉样蛋白原纤维悬浮液的分离 许多病毒，例如 SARS-CoV-2，被包裹在脂质膜中，它们可以利用 事实证明，用于包装核酸货物的 LC 订单在检测和检测方面非常敏感。 报告病原体和毒素的存在，使它们对自主生物非常感兴趣 /化学传感器因此是保持我们健康和导致疾病的一个组成部分，并且 尽管这种联系早已为人所知，但它们正在成为检测疾病病原体的强大工具。 迄今为止，它的研究还很有限，在解决社会问题方面构成了一个尚未充分探索的机会。 今天，国际液相色谱研究界正在经历重生，完全接受这些需求。 LC 科学与生物、生命和制药科学的跨学科交叉，以及 工程和材料科学在利用机遇方面发挥着开创性作用。 NIH-NIBIB 任务的核心领域来自例如软执行器中液晶弹性体的探索 或植入人体。 主席寻求戈登研究会议（GRC）的支持。 液晶研讨会 (GRS) 2023：“通过液晶从自然到转型技术- tal Science”，南新罕布什尔大学，曼彻斯特，新罕布什尔州，6 月 24 日至 25 日（GRS），6 月 25 日至 6 月 30 日（GRC）， 2023 年。联席会议将汇集当今充满活力的前沿领域的美国和国际研究人员 LC 科学，跨越其全部广度，连接学术界、工业界和军事实验室，无论年轻还是资深， 利用一切机会提升妇女和代表性不足的少数群体作为发言人，讨论主要议题 30 位著名演讲者已确认我们的演讲邀请。 尖端研究，涵盖例如自然界中的液晶、胶体和聚合物中的液晶自组装，以及 在新兴应用中，52% 的演讲者是女性，37% 的演讲者是非白人。 此外，还将给予优秀的5个扬声器插槽 从提交的海报摘要中选出的年轻科学家为了进一步增强年轻研究人员的声音， GRC 之前是 GRS，仅面向学生和博士后，并提供指导和职业 在 GRC 期间，年轻科学家将在所有科学讨论中获得优先权。