Maximizing male fertility: the role of CRISP proteins.

最大化男性生育能力：CRISP 蛋白的作用。

• 批准号: DP200100659
• 负责人: Prof Moira O'Bryan
• 金额: $ 45.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100659
• 关键词: Maximizing; male; fertility; role; CRISP

This project aims to investigate the function of cysteine rich secretory protein (CRISP) family members in fertility. It is expected to generate new knowledge on the role CRISP1 and 4 play in sperm competition in vivo, and thus, evolutionary processes; to define the role seminal plasma CRISPs play in fertility; and identify the mechanism underpinning their biological activities. This will be achieved using a range of innovative, state-of-the-art approaches. Expected outcomes and benefits include an enhanced knowledge of the mechanisms underpinning fertility and infertility, enhanced collaboration and research knowhow, and an evidence base for future applied projects aimed enhancing fertility in agricultural species.

该项目旨在调查半胱氨酸丰富的分泌蛋白（CRISP）家庭成员在生育方面的功能。预计它将在体内精子竞争中发挥作用，从而产生新的知识，从而获得进化过程。定义精确的血浆薯片在生育中的作用；并确定其生物学活动的基础的机制。这将是使用一系列创新的最先进方法来实现的。预期的结果和益处包括增强对生育能力和不育的机制的知识，增强的协作和研究知识，以及未来应用项目的证据基础，旨在增强农业物种的生育能力。