A novel microtubule severing protein involved in male germ cell biology

一种参与男性生殖细胞生物学的新型微管切断蛋白

• 批准号: DP160100647
• 负责人: Prof Moira O'Bryan
• 金额: $ 27.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-14 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100647
• 关键词: novel; microtubule; severing; protein; involved

The project aims to better understand the cellular and biochemical mechanisms underlying a key component of male fertility. Microtubules are a fundamental component of all cells. A mechanism that is increasingly recognised as essential for microtubules regulation is severing. It has been discovered that an uncharacterised microtubule severing protein, KATNAL2, has a key role in male germ cell development. This project aims to define the mechanisms underlying KATNAL2 function in the male germ line. It is expected that these data will generate a comprehensive picture of KATNAL2 function and provide foundation data of relevance across multiple species and tissues. In the longer term, it may also reveal a rational strategy for fertility enhancement or suppression.

该项目旨在更好地了解男性生育能力关键成分的基础的细胞和生化机制。微管是所有细胞的基本组成部分。越来越多地被认为是微管调节必不可少的机制正在截然不同。已经发现，未表征的微管切断蛋白Katnal2在男性生殖细胞发育中具有关键作用。该项目旨在定义男性生殖系中Katnal2功能的基础机制。预计这些数据将产生Katnal2功能的全面图片，并为多种物种和组织提供相关性的基础数据。从长远来看，它也可能揭示了生育能力增强或抑制的合理策略。