Mechanisms of manchette function

Manchette功能机制

• 批准号: DP180100533
• 负责人: Prof Moira O'Bryan
• 金额: $ 24.37万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100533
• 关键词: Mechanisms; manchette; function

This project aims to define the function of the manchette, a poorly understood microtubule-based structure present in haploid male germ cells. This project aims to define key mechanisms underpinning manchette development and movement, and to generate a detailed picture of the dynamics of germ cell development using imaging technologies and unique animal models. Such knowledge should improve the understanding of how male fertility is achieved, the origin of infertility and how species-specific differences in sperm form are achieved. Such insights may ultimately lead to improved agricultural efficiencies and job creation.

该项目旨在定义Manchette的功能，该项目是单倍体男性生殖细胞中存在的一个基于微管的结构。该项目旨在定义基于生产者开发和运动的关键机制，并使用成像技术和独特的动物模型生成生殖细胞开发动力学的详细图片。这种知识应提高人们对男性生育方式的理解，不育的起源以及如何实现精子形式的物种特异性差异。这种见解最终可能会提高农业效率和创造就业机会。