Sperm ciliary gating and midpiece formation – a novel player and process

精子纤毛门控和中段形成——新颖的参与者和过程

• 批准号: DP230100747
• 负责人: Prof Moira O'Bryan
• 金额: $ 43.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100747
• 关键词: Sperm; ciliary; gating; midpiece; formation

We have identified CCDC112 an essential player in mammalian sperm tail development and male fertility. This project aims to define the role of CCDC112 in 1) the formation of the core to the sperm tail, the axoneme, and 2) the packaging of mitochondria into the midpiece. Within this Discovery Project we will define the mechanism(s) of CCDC112 functions and the consequences of its dysfunction. Insights from this grant will be of significance to fertility across mammals and may ultimately benefit the selection of highly fertile males within the agricultural sector.

我们已经确定CCDC112是哺乳动物精子尾巴发育和男性生育能力的重要参与者。该项目的目的是定义CCDC112在1）核心形成精子尾，轴突和2）线粒体将线粒体包装到中间组中的作用。在这个发现项目中，我们将定义CCDC112功能的机制及其功能障碍的后果。这笔赠款的见解将对跨哺乳动物的生育具有重要意义，并最终可能使农业部门内高肥沃的雄性的选择有益。