Prevalence and Impact of Frailty among Dialysis Patients

透析患者虚弱的患病率和影响

基本信息

批准号：
10180945
负责人：
KIRSTEN L. JOHANSEN
金额：
$ 14.9万
依托单位：
HENNEPIN HEALTHCARE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-18 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10180945
关键词：
Adverse event Age Award Biological Markers Body Weight decreased C-reactive protein Caring Cessation of life Chronic Disease Chronic Kidney Failure Clinical Communities Data Development Dialysis patients Dialysis procedure Elderly End stage renal failure Environment Evaluation Evolution Fluid overload Fracture Functional disorder Funding Hemodialysis Hormones Hospitalization Impairment Individual Inflammation Inflammatory Interleukin-6 Intervention Kidney Transplantation Lead Maintenance Measures Mentors Nephrology Outcome Patient Self-Report Patients Phenotype Physical Function Physical Performance Physical activity Physical assessment Physiological Polypharmacy Population Prevalence Prevention Proxy Recovery Reporting Research Research Personnel Research Support Resolution Risk Risk Factors Sampling Serum Sleep Stress Sum Syndrome System TNF gene Testing Testosterone Time Training Transplantation Treatment outcome Tumor Necrosis Factor Receptor United States National Institutes of Health Veterans Work adipokines adverse outcome career clinical care cohort comorbidity demographics disability exhaustion falls frailty functional status high risk improved improved functioning indexing inflammatory marker insight modifiable risk muscle metabolism next generation outcome prediction patient oriented research physical inactivity post-transplant premature prevent prognostic prognostic value programs remediation risk prediction model sex

项目摘要

PROJECT SUMMARY/ABSTRACT I am applying to renew my Mid-career Investigator Award in Patient Oriented Research (K24) in order to support my research and mentoring efforts. I am fully committed to patient oriented research and to training the next generation of researchers in nephrology research. I have developed a research program studying physical functioning in patients on dialysis, characterizing their limitations, studying the pathophysiology, and evaluating interventions to improve functioning. While my previous and currently funded work aims to assess frailty and its evolution among patients on dialysis, I am convinced that physical function and frailty could add important information to inform clinical care at other points along the spectrum of CKD. In particular, I plan to expand my focus to the transitions of care from non-dialysis requiring CKD to ESRD and from dialysis to transplantation. Aims are to examine associations of functional status during CKD with outcomes during ESRD in a national cohort of veterans and to measure physical performance in a cohort of kidney transplant candidates to determine the extent to which post-transplant outcomes are related to physical performance and frailty during pre-transplant evaluation. I have a strong track record of mentoring, and I work within a rich, supportive, and collegial environment at UCSF and in the Division of Nephrology. Continued K24 funding will permit me to continue to focus more of my time on research and mentoring and less on clinical and administrative work.

项目概要/摘要我正在申请续签我的以患者为导向的研究 (K24) 职业生涯中期研究员奖，以便支持我的研究和指导工作。我完全致力于以患者为导向的研究并培训肾脏病学研究的下一代研究人员。我制定了一项研究物理的研究计划透析患者的功能，描述其局限性，研究病理生理学，并评估改善功能的干预措施。虽然我之前和目前资助的工作旨在评估虚弱及其透析患者的进化，我相信身体功能和虚弱可能会增加重要的为 CKD 范围内其他方面的临床护理提供信息。特别是，我计划扩大我的重点关注从需要 CKD 的非透析到 ESRD 以及从透析到移植的护理转变。目的是在全国范围内检查 CKD 期间的功能状态与 ESRD 期间的结果之间的关联退伍军人队列并测量肾移植候选人队列的身体表现确定移植后结果与身体表现和虚弱程度相关的程度移植前评估。我在指导方面有着良好的记录，并且我在一个丰富、支持和支持的环境中工作。加州大学旧金山分校和肾脏科的学院环境。持续的 K24 资助将使我能够继续将更多时间集中在研究和指导上，而不是临床和行政工作上。

项目成果

期刊论文数量（87）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.

内皮功能障碍和动脉僵硬度与透析中低血压和高血压的关联。

DOI：
发表时间：
2011-07
期刊：
影响因子：
0
作者：
Dubin, Ruth;Owens, Christopher;Gasper, Warren;Ganz, Peter;Johansen, Kirsten
通讯作者：
Johansen, Kirsten

Physical activity and self-reported symptoms of insomnia, restless legs syndrome, and depression: the comprehensive dialysis study.

体力活动和自我报告的失眠、不宁腿综合征和抑郁症状：综合透析研究。

DOI：
发表时间：
2013-01
期刊：
影响因子：
0
作者：
Anand, Shuchi;Johansen, Kirsten L;Grimes, Barbara;Kaysen, George A;Dalrymple, Lorien S;Kutner, Nancy G;Chertow, Glenn M
通讯作者：
Chertow, Glenn M

Changes in serum inflammatory markers are associated with changes in apolipoprotein A1 but not B after the initiation of dialysis.

透析开始后，血清炎症标志物的变化与载脂蛋白 A1 的变化相关，但与 B 的变化无关。

DOI：
发表时间：
2014-02
期刊：
影响因子：
0
作者：
Kaysen, George A;Dalrymple, Lorien S;Grimes, Barbara;Chertow, Glenn M;Kornak, John;Johansen, Kirsten L
通讯作者：
Johansen, Kirsten L

Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease.

使用计步器增加患有慢性肾病的儿童和青少年的体力活动。

DOI：
发表时间：
2014-08
期刊：
影响因子：
0
作者：
Akber, Aalia;Portale, Anthony A;Johansen, Kirsten L
通讯作者：
Johansen, Kirsten L

Comparison of hospitalization rates among for-profit and nonprofit dialysis facilities.

营利性和非营利性透析机构住院率的比较。

DOI：
发表时间：
2014-01
期刊：
影响因子：
0
作者：
Dalrymple, Lorien S;Johansen, Kirsten L;Romano, Patrick S;Chertow, Glenn M;Mu, Yi;Ishida, Julie H;Grimes, Barbara;Kaysen, George A;Nguyen, Danh V
通讯作者：
Nguyen, Danh V