Baltimore CASCADE Study Site (BaCSS Project)

巴尔的摩 CASCADE 研究基地（BaCSS 项目）

基本信息

批准号：
10757186
负责人：
Clement Adebayo Adebamowo
金额：
$ 30.9万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10757186
关键词：
Address African American Age Age of Onset Alcohol abuse Area Artificial Intelligence Baltimore Caring Cervical Cervical Cancer Screening Characteristics Cities Clinical Clinical Research Clinical Sciences Clinical Trials Clinical Trials Network Clinical effectiveness Collaborations Colposcopy Communicable Diseases Communities Community Outreach Comprehensive Cancer Center County Cytopathology Data Data Science Development Disadvantaged Disease Early Diagnosis Emerging Technologies Enrollment Ethnic Origin Evaluation Evidence based intervention Excision Failure Gender Gynecologic Oncology HIV Health Health Services Accessibility Heterogeneity High Prevalence Home Housing Human Papillomavirus Human Resources Incidence Informatics Infrastructure Intervention Laboratories Leadership Link Malignant Neoplasms Malignant neoplasm of cervix uteri Maryland Mental Health Methods Neighborhoods Outcome Patients Population Population Sciences Poverty Pragmatic clinical trial Prevalence Prevention Protocols documentation Race Recurrent disease Research Resources Risk Risk Factors Sampling Services Site Substance abuse problem Technology Translational Research Transportation Universities University resources Viral Load result Visualization Woman cervical cancer prevention cervicovaginal chronic infection clinically significant community engagement comorbidity computerized data management economic disparity effectiveness clinical trial effectiveness evaluation ethnic disparity health care availability health care service health illiteracy high risk immune reconstitution implementation science implementation strategy improved inner city insight medical schools molecular diagnostics mortality new technology novel oncology service patient navigation peer support population based pragmatic implementation premalignant preventive intervention programs protocol development racial disparity recruit screening screening guidelines sex social disparities social health determinants uptake

项目摘要

Baltimore CASCADE Study Site (BaCSS Project) Project summary Women living with HIV (WLWH) have a higher risk of cervical cancer because of incomplete immune reconstitution and high prevalence of risk factors for cervical cancer. The risk is greater among African American (AA) WLWH in economically and socially disadvantaged areas such as West Baltimore because of intersection with race, gender, social determinants of health (SDOH), and HIV co-morbidities including substance abuse. Despite the widespread availability of population-based cervical cancer screening in the US, AA-WLWH living in disadvantaged areas have lower rates of screening uptake. Strategic evaluations of recently developed and emerging methods and technologies for cervical cancer prevention in intended use settings are urgently needed to address the cervical cancer prevention needs of this population. In the BaCSS project, we engage the clinical and population science resources of the University of Maryland School of Medicine (UMSOM) to establish a clinical study site for the CASCADE network. The site will enroll AA-WLWH into implementation science studies and clinical trials of evidence-based interventions for the prevention and early diagnosis of cervical cancer. The project provides operational leadership and pluripotent infrastructure for these studies in the CASCADE network and supports the development of concepts and protocols for pragmatic clinical trials of the effectiveness of clinically proven interventions to overcome barriers and reduce failures in cervical cancer prevention in WLWH.

巴尔的摩级联研究地点（BACS项目）项目摘要艾滋病毒（WLWH）的妇女因免疫不完全而患宫颈癌的风险更高宫颈癌危险因素的重建和高度流行率。非裔美国人的风险更大（aa）在经济和社会弱势群体中的WLWH，例如西巴尔的摩，因为交叉路口种族，性别，卫生社会决定因素（SDOH）和艾滋病毒合并症，包括滥用药物。尽管美国基于人群的宫颈癌筛查的广泛可用性，但居住在美国处境不利的地区的筛查率较低。最近开发的战略评估迫切需要在预防预防宫颈癌预防设置的宫颈癌预防的技术和技术满足该人群的宫颈癌预防需求。在BACS项目中，我们参与了大学的临床和人口科学资源马里兰州医学院（UMSOM）为级联网络建立临床研究地点。该网站将将AA-WLWH招募到实施科学研究和基于证据的干预措施的临床试验预防和早期诊断宫颈癌。该项目提供运营领导和多功能这些研究在级联网络中的基础架构，并支持概念和务实临床试验的方案，该试验是临床证明的干预措施以克服障碍的有效性并减少WLWH宫颈癌预防的衰竭。