ICH Recovery Grant

ICH 恢复补助金

• 批准号: 10159984
• 负责人: Daniel Woo
• 金额: $ 70.04万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159984
• 关键词: Address; Adult; Affect; Age; Alleles; Alzheimer' s Disease; Amyotrophic Lateral Sclerosis; Apolipoprotein E; Area; Attention; Axon; Biological; Blood; Brain hemorrhage; Cause of Death; Cerebral hemisphere hemorrhage; Cerebrum; Cognitive; Corticospinal Tracts; Data; Diffusion Magnetic Resonance Imaging; Disabled Persons; Environmental Risk Factor; Evaluation; Follow-Up Studies; Gait; Gait Ataxia; Gender; Genes; Genetic Risk; Genotype; Glasgow Coma Scale; Grant; Hematoma; Hemorrhage; Hydrocephalus; Image; Impaired cognition; Impairment; Incontinence; Injury; Intervention Studies; Intervention Trial; Intracranial Hypertension; Intraventricular; Ischemic Stroke; Language; Literature; Lobar; Location; Magnetic Resonance Imaging; Measures; Memory; Motor; Multiple Sclerosis; National Institute of Neurological Disorders and Stroke; Normal Pressure Hydrocephalus; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Parents; Parkinson Disease; Patients; Phenotype; Population; Process; Quality of life; Randomized Controlled Trials; Recovery; Reporting; Research Design; Research Personnel; Resources; Risk; Rupture; Sampling; Scanning; Seminal; Severities; Stretching; Stroke; Supratentorial; Survivors; Symptoms; Testing; Tissues; Toxic effect; United States; Vascular Cognitive Impairment; Ventricular; base; cognitive function; disability; epidemiology study; executive function; follow-up; functional disability; functional outcomes; imaging study; improved; injured; innovation; intraventricular hemorrhage; mortality; motor deficit; motor recovery; neural tract; neuroimaging; novel; outcome prediction; population based; post stroke; preservation; primary outcome; prospective; randomized trial; recruit; sex; stroke victims; tractography; transcriptome sequencing

Project Summary/Abstract Stroke is the third leading cause of death and the leading cause of adult disability in the United States. More adults are affected by stroke each year than Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis or Parkinson’s disease. Hemorrhagic strokes represent the most severe subtypes of stroke. An estimated 40- 50% of hemorrhagic stroke victims will die and more than 80% of survivors remain disabled after hemorrhagic stroke. Yet the vast majority of analyses on outcome after stroke have focused principally on gross measures of functional outcome. Furthermore, hemorrhagic stroke differs from ischemic stroke where a loss of blood causes the area affected to be readily visible on scanning. But with hemorrhagic stroke, not only the area that we can directly see, but nearby tracts that have been compressed or stretched by the mass of the hemorrhage can be injured. We propose to follow-up on 500 cases of deep and lobar ICH to perform serial evaluations of motor and cognitive function and advanced neuroimaging to determine predictors of recovery, progressive cognitive or functional impairment. Our proposal has the advantages of adding onto a prospective ICH study which will identify and recruit cases, ability to evaluate for the degree and impact of survival and severity biases, baseline neuroimaging which includes baseline MRI, biologic samples including genotyping for apolipoprotein E alleles and uniform phenotype definitions as well as expertise in recovery/outcome analyses, advanced neuroimaging processes and epidemiologic study.

项目概要/摘要 中风是美国第三大死亡原因，也是导致成人残疾的主要原因。 每年成年人中风的人数比阿尔茨海默病、多发性硬化症、肌萎缩侧索硬化症还要多 或帕金森病是最严重的中风亚型，估计有 40- 50% 的出血性中风患者会死亡，超过 80% 的幸存者在出血性中风后仍然残疾 然而，绝大多数对中风后结局的分析主要集中在总体指标上。 的功能结果。 此外，出血性中风与缺血性中风不同，缺血性中风是由于失血导致受影响的区域 扫描时很容易看到，但对于出血性中风，不仅是我们可以直接看到的区域，而且 附近被大量出血压缩或拉伸的纤维束可能会受伤。 我们建议对 500 例深部和脑叶 ICH 病例进行随访，以对运动和脑区进行系列评估。 认知功能和先进的神经影像学，以确定恢复、渐进认知或 我们的建议的优点是增加了前瞻性 ICH 研究，这将 识别和招募病例、评估生存和严重性偏差的程度和影响的能力、基线 神经影像，包括基线 MRI、生物样本（包括载脂蛋白 E 等位基因的基因分型） 和统一的表型定义以及恢复/结果分析、高级神经影像学方面的专业知识 过程和流行病学研究。

项目成果

Humanizing Radiology Appointment Education to Improve Patient Experience.

人性化放射科预约教育，改善患者体验。

• 发表时间: 2022-05
• 作者: Wahab, Shaun A;Wahab, Rifat A;Butcher, Bain;Brown, Ann;Mahoney, Bruce;Chadalavada, Seetharam;Lecky, Shari S;Washburn, Erica;Allen, Becky;Vogel, Craig;Mahoney, Mary;Vagal, Achala
• 通讯作者: Vagal, Achala