Recovery of StrokE - Longitudinal Assessment With Neuroimaging (ROSE LAWN)

StrokE 的恢复 - 神经影像纵向评估 (ROSE LAWN)

基本信息

批准号：
10542718
负责人：
Daniel Woo
金额：
$ 75.2万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-15 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10542718
关键词：
Acute Address Affect African American population Age Ancillary Study Atrophic Behavioral Biological Markers Blinded Blood Vessels Brain hemorrhage Budgets CASP2 gene Cerebral Amyloid Angiopathy Cerebral hemisphere hemorrhage Cerebral small vessel disease Chronic Clinical assessments Cognitive Contralateral DNA Data Deferoxamine Dementia Deterioration Development Diffusion Magnetic Resonance Imaging Disabled Persons Enrollment Evaluation Funding Gene Expression Hemorrhage Hemosiderin Hypertension Image Impaired cognition Incidence Inflammation Inflammatory Inflammatory Response Interleukin-8 Iron Chelating Agents Lacunar Infarctions Leukocytes Longterm Follow-up Magnetic Resonance Imaging Measurement Measures Mediation Microvascular Dysfunction Minority Molecular Genetics Motor Outcome Patients Phenotype Population Prevention Principal Investigator Prospective Studies RNA Recording of previous events Recovery Reporting Risk Risk Factors Role Sampling Serum Siderosis Statistical Data Interpretation Stroke Supratentorial Survivors United States National Institutes of Health Variant White Matter Disease cohort dementia risk disability follow-up high risk inflammatory marker multidisciplinary neuroimaging neuroimaging marker novel patient population programs recruit stroke recovery tractography transcriptome sequencing

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Woo, Daniel; Anderson, Christopher 3. Project Summary/Abstract We have recently completed analyses which identifies a population of patients that have a markedly increased risk of developing dementia/progressive cognitive impairment. Intracerebral hemorrhage patients had been reported to have a 42% risk of progressive cognitive impairment roughly 3 and a half years after their stroke and we have found a 39% risk in an independent population of patients. This extraordinarily high rate among survivors of ICH without a prior history of dementia yields multiple different hypotheses. First, it may be that the causes of ICH itself are also risk factors for dementia. If so, then those that develop dementia should demonstrate worsening markers of these causes such as cerebral small vessel disease and cerebral amyloid angiopathy. However, another prominent hypothesis in the field is that the hemorrhage itself is markedly inflammatory. If this inflammatory response were to trigger a progressive cognitive decline, then these cases should demonstrate differential inflammatory gene expression changes. The Recovery of StrokE (NS100417) study has recruited 163 cases out of a planned 500 total cases of ICH including 3T MRI, baseline and 3 month samples for DNA, RNA-sequencing and detailed baseline, 3 and 6 month motor, cognitive, behavioral and functional examinations. The current proposal seeks to re-enroll 250 cases of the planned 500 for 12 to 24 month follow-up neuroimaging, RNA sampling and repeated examination measures to address the following aims: 1) Determine if progressive cognitive impairment correlates with an increase in markers of cerebral small vessel disease and cerebral amyloid angiopathy; 2) Determine if inflammation as measured by RNA-sequencing markers of inflammation correlates with progressive cognitive impairment and 3) identify novel neuroimaging markers associated with progressive cognitive decline. If successful, we will provide the largest longitudinal multiple assessment evaluation of ICH and answer the major hypotheses on the development of dementia among survivors of ICH. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Woo, Daniel；安德森·克里斯托弗 3. 项目概要/摘要我们最近完成了分析，确定了具有显着症状的患者群体患痴呆症/进行性认知障碍的风险增加。脑出血患者有据报道，中风后大约 3 年半内出现进行性认知障碍的风险为 42% 我们发现在独立的患者群体中存在 39% 的风险。这个比率异常高没有痴呆病史的脑出血幸存者得出了多种不同的假设。首先，可能是 ICH本身的原因也是痴呆症的危险因素。如果是这样，那么那些患有痴呆症的人应该证明这些原因的恶化标志物，例如脑小血管疾病和脑淀粉样血管病。然而，该领域的另一个重要假设是出血本身具有明显的炎症性。如果这个炎症反应会引发进行性认知能力下降，那么这些病例应该证明差异性炎症基因表达变化。中风恢复 (NS100417) 研究已在计划的 500 例 ICH 病例中招募了 163 例包括 3T MRI、基线和 3 个月 DNA 样本、RNA 测序和详细基线、3 和 6 每月进行运动、认知、行为和功能检查。目前的提案旨在重新注册 250 计划对 500 例病例进行 12 至 24 个月的随访神经影像学、RNA 采样和重复检查旨在实现以下目标的措施： 1) 确定进行性认知障碍是否与脑小血管疾病和脑淀粉样血管病标志物增加； 2）确定是否通过炎症RNA测序标记物测量的炎症与进行性认知能力相关损伤；3) 识别与进行性认知衰退相关的新型神经影像标记。如果成功，我们将提供最大的ICH纵向多重评估评估并回答关于 ICH 幸存者中痴呆症发展的主要假设。 PHS 398/2590（修订版 06/09）页面延续格式页面