ACOUSTIC CHIASM--ANATOMY AND BEHAVIOR

声交叉——解剖与行为

• 批准号: 2125060
• 负责人: KAREN K GLENDENNING
• 金额: $ 16.21万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-01-01 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2125060
• 关键词: aspartate; auditory pathways; behavior test; cats; experimental brain lesion; glutamates; glycine; hearing; immunocytochemistry; kainate; neuroanatomy; neurochemistry; neurotoxins; olivary body; perception; psychoacoustics; receptor binding

Ablation behavior experimentation on the hindbrain auditory system has led to the conclusion that the superior olivary complex (or SOC) in the medulla may serve the auditory system as an "acoustic chiasm". The primary evidence is that unilateral lesions in the auditory pathway anywhere below this structure (that, in the cochlea, cochlear nucleus, trapezoid body) result in sound localization deficits either in both hemifields of auditory space or in the hemifield ipsilateral to the lesion. In sharp contrast, unilateral lesions in the pathway anywhere above the SOC (that is, in the lateral lemniscus or beyond) result in sound localization deficits only in the hemifield contralateral to the lesion. Therefore, there is a clear functional parallel between the SOC and the optic chiasm even though there is no obvious anatomical parallel. We propose to continue studying the anatomical and neurochemical basis and the functional consequences of this chiasm-like process in a series of tract-tracing, 2-DG, transmitter-identification, and ablation-behavior experiments in cats. In the new project period we will focus much of our early effort on the efferent projections of LSO and then on the afferents and efferents of DLL. Because the project entails rigorous psychophysical tests of sound localization capacities before and after selective hindbrain tract- sections or nuclear ablations, we hope the research will contribute to the understanding of auditory dysfunction in humans.

后代听觉系统上的消融行为实验具有 得出的结论是，上级橄榄综合体（或SOC） 髓质可以用作听觉系统作为“声学chiasm”。 这 主要证据是听觉途径中的单侧病变 此结构以下的任何地方（在耳蜗中，人工耳蜗核， 梯形体）导致声音定位缺陷在两个 听觉空间的半场或半侧的同侧 病变。 形成鲜明对比的是，任何地方的路径中的单侧病变 在SOC上方（即，在Lemniscus外侧或以后）导致 声音本地化仅在半场对侧缺陷 病变。 因此，SOC之间存在明显的功能相似之处 即使没有明显的解剖学平行，视神经段也是如此。 我们建议继续研究解剖学和神经化学基础 以及此类似CHIASM的过程的功能后果 路面，2-DG，发射器识别和烧蚀行为 猫的实验。 在新项目时期，我们将集中精力 早期对LSO的传出预测，然后在传出中进行的努力 和dll的传出。 因为该项目需要对声音的严格心理物理测试 选择性后脑道之前和之后的定位能力 部分或核消融，我们希望研究能够促进 对人类听觉功能障碍的理解。