ACOUSTIC CHIASM: ANATOMY AND BEHAVIOR

声交叉：解剖和行为

• 批准号: 3216080
• 负责人: KAREN K GLENDENNING
• 金额: $ 14.27万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-01-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3216080
• 关键词: auditory discrimination; auditory nuclei; auditory pathways; auditory reflex; auditory threshold; autoradiography; binaural hearing; brain mapping; cats; efferent nerve; electrophysiology; experimental brain lesion; gerbil /jird; hearing tests; histology; laboratory mouse; laboratory rat; neuroanatomy; neurophysiology; olivary body; psychoacoustics; sonar; sound frequency; swine; auditory discrimination; auditory nuclei; auditory pathways; auditory reflex; auditory threshold; autoradiography; binaural hearing; brain mapping; cats; efferent nerve; electrophysiology; experimental brain lesion; gerbil /jird; hearing tests; histology; laboratory mouse; laboratory rat; neuroanatomy; neurophysiology; olivary body; psychoacoustics; sonar; sound frequency; swine

Ablation behavior experimentation on the hindbrain auditory system has led to the conclusion that the superior olivary complex (or SOC) in the medulla may serve the auditory system as an "acoustic chiasm". The primary evidence is that unilateral lesions in the auditory pathway anywhere below this structure (that is, in the cochlea, cochlear nucleus, trapezoid body) result in sound localization deficits either in both hemifields of auditory space of in the hemifield ipsilateral tot he lesion. In sharp contrast, unilateral lesions in the pathway anywhere above the SOC (that is, in the lateral lemniscus or beyond) result in sound localization deficits only in the hemifield contralateral to the lesion. Therefore, there is a clear functional parallel between the SOC and the optic chiasm even though there is no obvious anatomical parallel. We propose to continue studying the anatomical basis and functional consequences of this chiasm-like process in a series of tract-tracing, 2-DG, transmitter-identification, and ablation-behavior experiments in cats. In the new project period we will focus much of our early effort on the afferent supply and integrative activity of MSO and the relationship of its efferents to the ipsilateral efferent projections of LSO. Because the project entails rigorous psychophysical tests of sound localization acuity and basic hearing capacities before and affter selective hindbrain tract-sections, we hope the research will contribute to the understanding of retrocochlear dysfunction in humans.

后代听觉系统的消融行为实验已引导 得出的结论是，延髓中的上橄榄络合物（或SOC） 可以用作听觉系统作为“声学chiasm”。 主要 有证据表明听觉途径中的单侧病变以下任何位置 这种结构（即，在耳蜗中，耳蜗核，梯形体） 导致在听觉的两个半场中都会导致声音定位缺陷 半场同侧的空间。 与形成鲜明对比的是 路径中的单侧病变（即 外侧lemniscus或以后）仅在 半场与病变对侧。 因此，有一个清晰的 即使在那里 没有明显的解剖平行。 我们建议继续研究解剖基础和功能 在一系列段落追踪中，这种类似CHIASM的过程的后果， 2-DG，发射器识别和消融行为实验 猫。 在新的项目时期，我们将大部分早期的努力集中在 MSO的传入供应和综合活动以及 它对LSO的同侧屈从性预测。 因为 项目需要严格的心理物理测试，对声音定位敏锐度 和以前的基本听力能力以及选择性后脑 区域，我们希望研究将有助于理解 人类倒角功能障碍。