GENETIC & ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGING

基因

• 批准号: 2051438
• 负责人: NANCY L PEDERSEN
• 金额: $ 40.77万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-18 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2051438
• 关键词: Scandinavian country; aging; behavior test; behavioral genetics; blood chemistry; cognition; data collection; environmental adaptation; family structure /dynamics; functional ability; health behavior; health surveys; human old age (65+); human subject; interview; longitudinal human study; nutrition; nutrition related tag; quality of life; questionnaires; social support network; socioeconomics; twin /multiplet

The primary purpose of the proposed research is to capitalize on an initial investment of the National Institute on Aging (AGO4563) which in 1984 launched the only longitudinal behavioral genetic analysis of individual differences in functioning later in life. The study, called the Swedish Adoption/Twin Study of Aging (SATSA), uses the powerful design of twins reared together and twins read apart, and has become a landmark study of gerontological genetics. SATSA now has the opportunity to study this unique sample a decade later through the inclusion of a third wave of in-person testing (IPT3) and a fourth wave of questionnaire assessment (Q4). Approximately 600 individuals will be tested in IPT3, and 2,000 individuals will receive Q4. Longitudinal data to be collected in IPT include measures of health and health-related behavior, nutritional status, activities of daily living, functional capacity, and cognition. The questionnaire phase covers self-perceived impairment due to health-related outcomes, personality, and measures of the environment including life events, social support, socioeconomic status and the family environment. The powerful adoption/twin design of SATSA provides a compelling basis for analyzing issues of genetic and environmental contributions to change and continuity in biobehavioral aging. Extension of SATSA to three measurement occasions will enable quantitative genetic analyses of research issues related to the shape of growth curves, such as the importance of genetic factors for terminal decline and reduction in functional capacity. Three points of measure provide a more appropriate basis for examining structural change in the relationship of measures within and between biobehavioral domains. Thus, analyses will also be concerned with assessing the extent to which genetic and environmental factors mediate the relationship between health, cognition and well-being in the elderly. More refined analyses of the etiology of developmental turning-points and the mechanisms contributing to longitudinal stability and change will be possible with the inclusion of a fourth occasion. Predictive relationships, such as the impact of life events and social support on cognitive and health outcomes at subsequent occasions, will also be the object of study.

拟议研究的主要目的是利用 国家老龄化研究所 (AGO4563) 的初始投资 1984年推出唯一的纵向行为遗传分析 以后生活中功能的个体差异。 这项研究名为 瑞典收养/双胞胎老龄化研究 (SATSA)，使用强大的 双胞胎一起长大、双胞胎分开阅读的设计，已经成为一种 老年遗传学的里程碑式研究。 SATSA现在有机会 十年后通过纳入一个研究这个独特的样本 第三波现场测试（IPT3）和第四波问卷调查 评估（Q4）。 大约 600 人将接受 IPT3 测试， 2,000 人将获得 Q4。 要收集的纵向数据 IPT 包括健康和健康相关行为的测量， 营养状况、日常生活活动、功能能力以及 认识。 问卷阶段涵盖由于以下原因造成的自我感知障碍 与健康相关的结果、个性和环境措施 包括生活事件、社会支持、社会经济地位和 家庭环境。 SATSA 强大的采用/孪生设计提供了 分析遗传和环境问题的令人信服的基础 对生物行为衰老的变化和连续性的贡献。 将 SATSA 扩展到三个测量场合将使 与形状相关的研究问题的定量遗传分析 生长曲线，例如遗传因素对终末期的重要性 功能能力下降和减少。 三点测量 为审查结构性变化提供更合适的基础 生物行为领域内和之间的测量关系。 因此， 分析还将涉及评估 遗传和环境因素介导两者之间的关系 老年人的健康、认知和福祉。 更精细的分析 发育转折点的病因学和机制 有助于纵向稳定性和变化将有可能 包括第四次机会。 预测关系，例如 生活事件和社会支持对认知和健康的影响 后续事件的结果，也将成为研究的对象。