Interstitial Cystitis in Swedish Twins

瑞典双胞胎间质性膀胱炎

• 批准号: 6711840
• 负责人: NANCY L PEDERSEN
• 金额: $ 29.67万
• 依托单位: KAROLINSKA INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6711840
• 关键词: Scandinavian country; clinical research; comorbidity; cooperative study; disease /disorder etiology; gene environment interaction; genetic susceptibility; human subject; interstitial cystitis; interview; questionnaires; twin /multiplet

DESCRIPTION (provided by applicant): The overarching purpose of this proposal is to address a set of critical questions about the etiology of interstitial cystitis (IC) using multivariate data from a large population-based classical twin study. Despite ongoing research, IC remains a controversial entity for two critical reasons. First, the validity of the case definition remains uncertain. There are few data that address a historically important validator--the degree to which IC results from genetic and/or environmental factors. Second, IC is often comorbid with one or more additional physical disorders and yet the causes of comorbidity are uncertain. Taken together, these two sets of unanswered questions contribute significantly to the controversies that continue to surround IC. Moreover, the strong female predominance of IC has been amply documented but is not well understood. To address these fundamental issues, we propose to conduct a twin study of IC in the population-based Swedish Twin Registry (STR). We propose to assess IC in the cohort of STR twins aged 18-45 years using a web-based screening instrument. Those not participating in the web-based assessment will be offered a computer assisted telephone interview. Based on previous experience, we anticipate that of the 50,011 individuals in this cohort, 75% or 37,500 will respond. These unique data will be used to address the following Specific Aims: (1) To estimate the prevalence of IC and its key co-morbidities in STR participants. To assess the phenotypic patterns of comorbidity of IC with other disorders. (2) To evaluate the genetic and environmental sources of variation for IC through concordances and structural equation modeling. To examine the effects of gender on these effects. (3) To use multivariate twin analyses to investigate the sources of covariation between IC and its frequently co-morbid conditions and (4) To use case-control designs with external controls and internal controls ("co-twin control" design) to evaluate the importance of exposures which may infer risk for disease.

描述（由申请人提供）： 该提案的首要目的是利用基于大规模人群的经典双胞胎研究的多变量数据来解决一系列有关间质性膀胱炎 (IC) 病因学的关键问题。尽管研究正在进行，但由于两个关键原因，IC 仍然是一个有争议的实体。首先，案例定义的有效性仍不确定。很少有数据涉及历史上重要的验证因素——遗传和/或环境因素导致 IC 的程度。其次，IC 通常与一种或多种其他身体疾病共存，但共病的原因尚不确定。总而言之，这两套悬而未决的问题极大地加剧了持续围绕 IC 的争议。此外，IC 中女性占主导地位的现象已得到充分记录，但尚未得到充分理解。 为了解决这些基本问题，我们建议在基于人群的瑞典双胞胎登记处 (STR) 开展一项 IC 双胞胎研究。我们建议使用基于网络的筛查工具评估 18-45 岁 STR 双胞胎队列中的 IC。那些不参加基于网络的评估的人将获得计算机辅助的电话面试。根据以往的经验，我们预计在该队列的 50,011 人中，75%（即 37,500 人）会做出回应。这些独特的数据将用于实现以下具体目标：(1) 估计 STR 参与者中 IC 的患病率及其主要合并症。评估 IC 与其他疾病合并症的表型模式。 (2) 通过索引和结构方程模型评估IC变异的遗传和环境来源。检查性别对这些影响的影响。 (3) 使用多变量双生分析来研究 IC 与其常见共病状况之间的协变来源，以及 (4) 使用具有外部对照和内部对照的病例对照设计（“双生对照”设计）来评估可能推断疾病风险的暴露的重要性。