Interstitial Cystitis in Swedish Twins

瑞典双胞胎间质性膀胱炎

• 批准号: 6899677
• 负责人: NANCY L PEDERSEN
• 金额: $ 100.79万
• 依托单位: KAROLINSKA INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6899677
• 关键词: Scandinavian country; clinical research; comorbidity; cooperative study; disease /disorder etiology; gene environment interaction; genetic susceptibility; human subject; interstitial cystitis; interview; questionnaires; twin /multiplet

DESCRIPTION (provided by applicant): The overarching purpose of this proposal is to address a set of critical questions about the etiology of interstitial cystitis (IC) using multivariate data from a large population-based classical twin study. Despite ongoing research, IC remains a controversial entity for two critical reasons. First, the validity of the case definition remains uncertain. There are few data that address a historically important validator--the degree to which IC results from genetic and/or environmental factors. Second, IC is often comorbid with one or more additional physical disorders and yet the causes of comorbidity are uncertain. Taken together, these two sets of unanswered questions contribute significantly to the controversies that continue to surround IC. Moreover, the strong female predominance of IC has been amply documented but is not well understood. To address these fundamental issues, we propose to conduct a twin study of IC in the population-based Swedish Twin Registry (STR). We propose to assess IC in the cohort of STR twins aged 18-45 years using a web-based screening instrument. Those not participating in the web-based assessment will be offered a computer assisted telephone interview. Based on previous experience, we anticipate that of the 50,011 individuals in this cohort, 75% or 37,500 will respond. These unique data will be used to address the following Specific Aims: (1) To estimate the prevalence of IC and its key co-morbidities in STR participants. To assess the phenotypic patterns of comorbidity of IC with other disorders. (2) To evaluate the genetic and environmental sources of variation for IC through concordances and structural equation modeling. To examine the effects of gender on these effects. (3) To use multivariate twin analyses to investigate the sources of covariation between IC and its frequently co-morbid conditions and (4) To use case-control designs with external controls and internal controls ("co-twin control" design) to evaluate the importance of exposures which may infer risk for disease.

描述（由申请人提供）： 该提案的总体目的是通过基于大型人群的经典双胞胎研究中的多元数据解决有关间质膀胱炎（IC）病因的一系列关键问题。尽管进行了持续的研究，但由于两个关键原因，IC仍然是一个有争议的实体。首先，案例定义的有效性仍然不确定。很少有数据解决历史上重要的验证器 - 遗传和/或环境因素产生的IC的程度。其次，IC通常与一种或多种其他身体疾病合并，但合并症的原因尚不确定。综上所述，这两组未解决的问题对继续围绕IC的争议产生了重大贡献。此外，IC的强大女性优势已得到充分的记录，但尚未得到充分理解。 为了解决这些基本问题，我们建议在基于人群的瑞典双注册中心（STR）中对IC进行双胞胎研究。我们建议使用基于Web的筛选工具在18-45岁的Str双胞胎中评估IC。那些未参加基于Web的评估的人将获得计算机辅助电话采访。根据以前的经验，我们预计该队列中的50,011个人中有75％或37,500人会做出回应。这些独特的数据将用于解决以下特定目的：（1）估计IC及其在STR参与者中的关键合并症的患病率。评估IC与其他疾病合并症的表型模式。 （2）通过一致性和结构方程建模评估IC变异的遗传和环境源。检查性别对这些影响的影响。 （3）使用多元双胞胎分析来研究IC及其经常合并条件之间的协方差，以及（4）用外部控制和内部控制（“ Co-Twin Control”设计）使用病例对照设计，以评估可能推断出疾病风险的暴露的重要性。