Molecular Center of Health and Disease

健康与疾病分子中心

• 批准号: 10553864
• 负责人: MICHAEL R GARRETT
• 金额: $ 228.38万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-06 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553864
• 关键词: Academy; Address; Alzheimer' s Disease; Big Data Methods; Biological; Biology; CRISPR/Cas technology; Cause of Death; Centers of Research Excellence; Cessation of life; Chronic; Chronic Disease; Clinical; Collaborations; Computational Biology; Core Facility; Data; Data Set; Development; Diabetes Mellitus; Discipline; Disease; Disease Progression; Early Intervention; Education; Eligibility Determination; Environment; Funding; Genes; Genetic; Genetic Predisposition to Disease; Genome; Genomics; Goals; Health; Healthcare; Heart Diseases; Individual; Influenza; Infrastructure; Instruction; Interdisciplinary Study; Intervention; Kidney Diseases; Life; Malignant Neoplasms; Medical; Medical center; Mentors; Mentorship; Methodology; Methods; Mission; Mississippi; Molecular; Onset of illness; Organ; Pathway interactions; Peptide Initiation Factors; Persons; Phase; Physiological; Physiology; Pilot Projects; Population; Privatization; Process; Productivity; Proteomics; Qualifying; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Sepsis; Stroke; Technology; Therapeutic Intervention; Training; United States; Universities; Whole Organism; Work; career; career development; cost; data integration; diet and exercise; economic indicator; gene function; improved; individualized medicine; innovation; insight; metabolomics; novel; pathogen; programs; single-cell RNA sequencing; statistics; synergism; therapeutically effective; transcriptomics; translational approach

Overall-Abstract Chronic diseases, such as heart disease, diabetes, and cancer are among the most prevalent health conditions in the United States, responsible for 7 out of every 10 deaths. Mississippi ranks first or second in 8 of 10 leading causes of death, with 90% of the population having 1-2 chronic diseases. While chronic diseases can be treated through early intervention, targeted medical therapies, and improved diet and exercise, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a healthier state. Advances in technology now allow for unprecedented insight into genome complexity and its interaction with the environment using genomic, transcriptomic, proteomic, and metabolomic datasets. The integration of these datasets with physiological information using computational approaches can provide systematic insight into the molecular, cellular, and overall physiology associated with the health-disease continuum. We propose to establish a new Phase I COBRE, the Molecular Center of Health and Disease (MCHD) to facilitate research under a central theme of molecular physiology to enhance the depth of education, mentorship, and training of researchers to generate unique opportunities in the application of omics technology and computational biology. The MCHD will be comprised of multiple components including an administrative unit, education and mentoring programs, a pilot project program, two research cores, and three major project investigators. The overall objectives of the MCHD are: (1) to develop infrastructure and state-of- the-art research core facilities essential for cutting edge basic, clinical, and translational approaches to study the health and disease continuum. The MCHD, through Core B will enhance existing -omics technology (e.g., single cell RNAseq and spatial transcriptomics), proteomic capabilities, and establish a new innovative core, involving CRISPR/Cas9 gene-editing technology to interrogate gene function and biological pathways; and Core C will establish critical computing infrastructure and computational biology analysis not currently available at the University; (2) to establish meaningful education, mentoring programs, and research support for promising new investigators to nurture them into productive, independently funded investigators, who will be effective collaborators on multidisciplinary research teams. This will be accomplished through offering a “Genetic and - Omics Academy” (didactic instruction and observership) to strengthen researcher understanding of molecular and computational approaches, a robust mentoring program involving one-on-one and team mentoring, career development opportunities, and providing a high level of research support through each core; and (3) to enhance collaborations and interactions among investigators across multiple disciplines at UMMC, promote cooperation between other IDeA supported programs, including existing COBRE, IDeA-CTR, and external partnership with the Mississippi-INBRE.

总体提取 慢性疾病，例如心脏病，糖尿病和癌症是最普遍的健康状况之一 在美国，每10个死亡中有7人负责。密西西比州在10个领先中的8个中排名第一或第二 死亡原因，有90％的人口患有1-2个慢性疾病。虽然可以治疗慢性疾病 通过早期干预，有针对性的医疗疗法以及改善饮食和运动，了解 疾病发作涉及的遗传敏感性和分子机制有可能阻止进展 并将个人返回更健康的状态。技术的进步现在允许对 基因组复杂性及其与环境的相互作用使用基因组，转录组，蛋白质组学和 代谢组数据集。使用计算将这些数据集与物理信息集成 方法可以对与分子，细胞和整体生理学相关的系统性见解 健康疾病连续性。我们建议建立一个新的I阶段COBRE，即分子健康中心 和疾病（MCHD），以促进分子生理主题的研究以增强深度 对研究人员的教育，心态和培训，以在OMIC的应用中产生独特的机会 技术和计算生物学。 MCHD将完成多个组件，包括 行政部门，教育和心理计划，一个试点项目计划，两个研究核心和三个 主要项目调查员。 MCHD的总体目标是：（1）开发基础架构和最新 ART研究核心设施对于最前沿的基本，临床和翻译的方法至关重要 健康与疾病连续性。 MCHD通过核心B将增强现有的 - 摩西技术（例如，单一 细胞RNASEQ和空间转录组学），蛋白质组学功能，并建立一个新的创新核心，涉及 CRISPR/CAS9基因编辑技术，以询问基因功能和生物途径；核心将 建立关键的计算基础架构和计算生物学分析目前尚不可用 大学; （2）建立有意义的教育，心理计划和研究支持 调查人员将他们护理为富有成效的独立研究人员，他们将有效 多学科研究团队的合作者。这将通过提供“遗传和 - OMICS Academy”（教学教学和观察职位），以增强研究人员对分子的理解 和计算方法，这是一个涉及一对一和团队心理的强大心理计划 开发机会，并通过每个核心提供高水平的研究支持； （3）增强 UMMC跨多个学科的研究人员之间的合作和互动，促进合作 在其他受支持的计划之间，包括现有的毛病，Idea-CTR以及与外部伙伴关系 密西西比州的工资。