Core A- Administration, Education, and Mentoring

核心 A- 管理、教育和指导

• 批准号: 10553865
• 负责人: MICHAEL R GARRETT
• 金额: $ 56.84万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-06 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553865
• 关键词: Address; Advisory Committees; Area; Bioinformatics; Biometry; Cause of Death; Centers of Research Excellence; Charge; Chronic Disease; Collaborations; Complement; Computational Biology; Core Facility; Creativeness; Data Set; Diabetes Mellitus; Disease; Disease Progression; Early Intervention; Education; Ensure; Environment; Evaluation; Extramural Activities; Faculty; Feedback; Fostering; Funding; Genes; Genetic Predisposition to Disease; Genomics; Goals; Grant; Health; Heart Diseases; Individual; Infrastructure; Institution; Investigation; Kidney Diseases; Leadership; Medical; Medical center; Mentors; Mentorship; Methodology; Mission; Mississippi; Molecular; National Institute of General Medical Sciences; Onset of illness; Organism; Phase; Physiological; Physiology; Pilot Projects; Policies; Population; Program Development; Proteomics; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Socioeconomic Status; Stroke; Structure; Systems Biology; Teacher Professional Development; Technology; Training; United States; Universities; Whole Organism; Work; career; diet and exercise; early-career faculty; improved; individualized medicine; innovation; insight; lipidomics; meetings; member; metabolomics; multidisciplinary; new technology; novel; pathogen; programs; recruit; transcriptomics

Core A- Abstract The goal of the Molecular Center of Health and Disease (MCHD), a new Phase I COBRE, is to facilitate research under a central theme of molecular physiology to enhance the depth of education, mentorship, and training of researchers to generate unique opportunities to apply omics technology and computational biology across the health-disease continuum. While chronic diseases can be treated, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a more healthy state. The integration of genomic, transcriptomic, proteomic, and metabolomic datasets with physiological information using computational approaches can provide novel insight into the molecular, cellular, and overall physiology associated with the health-disease continuum. The MCHD will be comprised of multiple components including an administrative unit, education and mentoring programs, a pilot project program, two research cores, and three major project investigators. In particular, Core A- Administration, Education, and Mentoring will be charged with promoting the mission of the MCHD to facilitate the use of innovative approaches to study health, onset and progression of disease, and interaction with pathogens, with the goal of understanding the breadth of information from the molecular level to the whole organism. Core A will provide administrative support, coordinate activities of research cores (including Core B- Omics and Gene-Editing and Core C-Research Computing, Bioinformatics, and Biostatistics), coordinate governance activities (executive committee and internal and external advisory committees), develop and implement education and mentoring programs, facilitate the pilot project program; and work to promote collaboration with other IDeA supported programs (COBRE, INBRE, and IDeA-CTR). The broad objectives of the Core A are to: (1) establish and maintain an effective organizational and governance structure to support state-of-the-art cores essential for MCHD investigators to apply cutting edge omics and computational approaches to address important scientific questions related to the health and disease continuum; (2) promote a research environment that is creative, nurturing, collaborative and multidisciplinary by providing education in omics and computational approaches, supportive mentoring and research funding for major project and pilot project investigators; (3) identify and implement long-term strategies to maximize sustainability of the MCHD by seeking quality improvement, implementation of new technology for research innovation, recruitment of new faculty, and fostering important interactions with other IDeA program. In total, these aims will work synergistically to develop an innovative, state-of-the-art Phase I COBRE to strengthen institutional infrastructure, provide a robust research training and mentoring environment for a diverse group of early career investigators with the common goal of developing a better understanding of molecular underpinnings of health and chronic disease.

核心A-抽象 新阶段I的分子健康与疾病中心（MCHD）的目标是促进 在分子生理学的中心主题下进行研究，以增强教育，指导和 培训研究人员以产生独特的机会来应用OMICS技术和计算生物学 在整个健康疾病连续体中。虽然可以治疗慢性疾病，但对遗传的理解 疾病发作涉及的敏感性和分子机制具有阻止进展的潜力 将个人归还更健康的状态。基因组，转录组，蛋白质组学和 使用计算方法的代谢组数据集使用生理信息可以提供新颖的见解 进入与健康疾病连续体相关的分子，细胞和整体生理学。 MCHD 将由多个组成部分组成，包括行政部门，教育和指导计划， 试点项目计划，两个研究核心和三名主要项目调查员。特别是核心A- 行政，教育和指导将被指控将MCHD的使命提升为 促进使用创新方法来研究疾病的健康，发作和进展以及相互作用 使用病原体，目的是了解分子水平到整体的信息广度 生物。核心A将提供行政支持，协调研究核心的活动（包括核心B- OMICS和基因编辑以及核心C研究计算，生物信息学和生物统计学），坐标 治理活动（执行委员会以及内部和外部咨询委员会），成立和 实施教育和指导计划，促进试点项目计划；并努力促进 与其他受支持的程序（Cobre，Inbre和Idea-CTR）合作。广泛的目标 核心A将：（1）建立并保持有效的组织和治理结构以支持 MCHD调查人员应用最先进的OMICS和计算的最先进核心 解决与健康和疾病连续性有关的重要科学问题的方法； （2）促进 通过提供教育的研究环境 OMICS和计算方法，主要项目和飞行员的支持性指导和研究资金 项目调查人员； （3）确定并实施长期策略，以最大化MCHD的可持续性 寻求质量改进，实施新技术进行研究创新，招募新技术 教师，并促进与其他想法计划的重要互动。总的来说，这些目标将协同起作用 开发创新的，最先进的第一阶段毛绒，以加强机构基础设施，提供一个 为各种各样的早期职业调查人员组成的强大的研究培训和指导环境与 对健康和慢性疾病的分子基础有更好理解的共同目标。