Administrative Core

行政核心

基本信息

批准号：
10551704
负责人：
Michael R Yeaman
金额：
$ 16.15万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-10 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10551704
关键词：
Academic Medical Centers Accounting Achievement Administrator Area Benchmarking Bioinformatics Budgets Collaborations Communicable Diseases Communication Communities Computer Models Computer software Consultations Dedications Development Discipline Education Educational workshop Ensure Environment Epigenetic Process Equity Evaluation FAIR principles Faculty Funding Goals Grant Human Resources Infrastructure International Intranet Investigation Journals Learning Life Manuscripts Medical Medical center Mining Modeling Molecular Medicine Monitor National Institute of Allergy and Infectious Disease Network Infrastructure Outcome Performance Policies Postdoctoral Fellow Process Publishing Research Research Personnel Research Project Grants Resource Sharing Resources Role Sepsis Services Students System Systems Biology Technology Teleconferences Time Translational Research United States National Institutes of Health career career development clinical application cost effective data dissemination data management data sharing design digital epigenomics equity, diversity, and inclusion improved innovation meetings multidisciplinary novel outreach pathogen peer networks predictive modeling programs prospective skills success symposium synergism timeline translational applications translational potential

项目摘要

PROJECT SUMMARY/ABSTRACT The current Center proposal, entitled “Systems Epigenomics of Persistent Bloodstream Infection” represents a synergistic approach to understanding the host-pathogen interactions that result in life-threatening bloodstream infections that do not clear on appropriate therapy. A highly innovative and expert team has been assembled to implement a systems-biology strategy that is ideally aligned to achieve NIH / NIAID priorities. A diverse set of expertise, technologies and activities are necessary to efficiently reach our objectives. To effectively manage this integrated research program, we will implement our proven Administrative Network Core (ANC) to interact with each Project and Core. Thus, synergistic collaboration, research efficiency and discovery will be enhanced. The ANC design will afford highly efficient coordination among investigators and Center components, including Projects 1–3, and our Immunomics & Epigenetics (IEC), Bionformatics & Data Management (BDM) and Computational & Predictive Modeling (CPM) Cores. Coordination with Collaborators and Consultants by the ANC further amplifies the programmatic strengths of the Center. The ANC will provide a supportive infrastructure to ensure accomplishment of all Center goals: 1) managing the project financial and personnel resources; 2) facilitating coordination and integration of research Projects, Cores and Advisors; 3) ensuring quality improvement by monitoring of benchmark metrics and logistical optimization; 4) overseeing the solicitation, review, selection and monitoring of Supplemental Research Projects; and 5) promote a positive research environment that is equitable, inclusive and diverse. Thus, the ANC will support the overall Center to inform, coordinate, monitor and advance timely completion of all research goals.

项目摘要/摘要当前的中心提案，标题为“持续血液感染的系统表观基因组学”代表了解导致威胁生命的血液的宿主 - 病原体相互作用的协同方法在适当疗法上尚未清楚的感染。一支高度创新的专家团队已经组装实施一种系统生物学策略，理想地达到了实现NIH / NIAID优先事项的一致性。一系列专业知识，技术和活动对于有效达到我们的目标是必要的。有效管理这一集成的研究计划，我们将实施我们经过验证的行政网络核心（ANC）与每个项目互动，核。这将提高协同合作，研究效率和发现。 ANC设计将负担得起调查人员和中心组件之间的高效协调，包括项目1-3和我们的免疫学＆表观遗传学（IEC），Bionformatics＆Data Management（BDM）以及计算与预测建模（CPM）内核。与ANC的合作者和顾问的协调进一步放大器，该中心的计划优势。这 ANC将提供支持的基础设施，以确保实现所有中心目标：1）管理项目财务和人事资源； 2）支持研究项目，核心和顾问的协调和整合； 3）通过监视基准指标和后勤优化来确保质量提高； 4）监督补充研究项目的征求，审查，选择和监测； 5）促进积极的研究公平，包容和潜水员的环境。这是，ANC将支持整个中心以告知，协调，监视并及时完成所有研究目标。