Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders

改变威胁解释偏差以减少神经退行性运动障碍的焦虑

• 批准号: 10577294
• 负责人: Jessie Sellers Gibson
• 金额: $ 15.23万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577294
• 关键词: Address; Adult; American; Anxiety; Anxiety Disorders; Behavior Therapy; Benign; Breathing; COVID-19 pandemic; Caregiver Burden; Caregivers; Case Series; Clinical; Clinical Trials; Clinical Trials Design; Cognition; Cognitive; Cognitive Therapy; Collaborations; Communities; Data; Development; Diagnosis; Doctor of Philosophy; Environment; Evaluation; Evidence based treatment; FDA approved; Feedback; Foundations; Gait abnormality; Goals; Home; Huntington Disease; Individual; Internet; Intervention; Interview; Knowledge; Leadership; Measurement; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modification; Mood Disorders; Movement; Movement Disorders; Nerve Degeneration; Neurodegenerative Disorders; Nurses; Nursing Schools; Online Systems; Parkinson Disease; Participant; Patient Recruitments; Patients; Persons; Pharmaceutical Preparations; Phase; Physical activity; Population; Prevalence; Process; Protocols documentation; Provider; Quality of life; Recommendation; Research; Research Personnel; Sampling; Scientist; Strategic Planning; Subgroup; Symptoms; Testing; Thinking; Time; Training; Training Programs; Transportation; Universities; Virginia; Waiting Lists; Work; anxiety reduction; anxiety symptoms; anxious; career; career development; cognitive training; cost; design; digital; experience; flexibility; follow-up; functional status; human centered design; ideation; improved; improved outcome; innovative technologies; neuropsychiatric symptom; novel; off-label use; programs; prototype; psychologic; recruit; research and development; self-reported anxiety; sex; skills; stakeholder perspectives; success; symptom management; symptom treatment; therapy development; trait

PROJECT SUMMARY: The proposed K23 award will prepare Dr. Jessie Gibson, PhD, RN, AGPCNP-BC to become an independent investigator developing interventions for neuropsychiatric symptom management in neurodegenerative disease. Dr. Gibson’s clinical and research experiences have provided a foundation in identification, measurement, and effects of neuropsychiatric symptoms in Huntington’s disease (HD) and Parkinson’s disease (PD). The proposed research plan will prepare Dr. Gibson to take the next steps toward investigating treatment for these symptoms in independent clinical trials. Anxiety symptoms are extremely prevalent in HD and PD, causing significant burden for patients and caregivers. Unfortunately, there is limited evidence for how to treat these symptoms. Experts recommend use of psychological interventions to treat anxiety symptoms in HD and PD, but there have been few rigorous studies to support these recommendations. Cognitive bias modification for interpretation bias (CBM-I) paradigms address negative interpretation biases by training participants to (re)interpret ambiguous, potentially threatening situations in more benign ways to make anxious thinking more flexible. Our preliminary work has demonstrated feasibility of web-based CBM-I in this population and identified the need to adapt CBM-I programs to meet the needs of individuals with movement disorders. Our current objective is to determine whether a web-based cognitive bias modification for interpretation bias (CBM-I) intervention can reduce anxiety in PD and HD. Thus, we aim to: 1) gather stakeholder perspectives and 2) develop a web-based CBM-I intervention tailored to individuals with neurodegenerative movement disorders (MindTrails-Movement), then 3) evaluate target engagement and preliminary efficacy of MindTrails-Movement for reducing interpretation bias and anxiety symptoms in HD and PD. To carry out these aims and prepare Dr. Gibson to become a national leader in developing interventions for neuropsychiatric symptom management in neurodegenerative disease, she will work with an expert mentoring team led by Dr. Bethany Teachman, and including co-mentors Drs. Madaline Harrison, Carol Manning, Jeanne Alhusen, and Guofen Yan. Training experiences will support Dr. Gibson’s career development goals to: 1) cultivate skills to develop behavioral interventions using human-centered design; 2) develop expertise in clinical trial design and implementation; 3) establish advanced knowledge of mechanisms that maintain mood and anxiety disorders; and 4) develop leadership and grantsmanship skills and establish collaborations to prepare for a successful career as an independent nurse scientist. University of Virginia provides the ideal environment to achieve these research and career development goals, as home to a world- class nursing school, Huntington’s Disease Center of Excellence, American Parkinson’s Disease Association Advanced Center for Research, and the Program for Anxiety, Cognition and Treatment (PACT) lab- all of which are critical to the success of this proposal.

项目摘要：拟议的 K23 奖项将使 Jessie Gibson 博士（博士、注册护士、AGPCNP-BC）做好准备 成为一名独立研究者，开发神经精神症状管理干预措施 吉布森博士的临床和研究经验为神经退行性疾病奠定了基础。 亨廷顿病 (HD) 和神经精神症状的识别、测量和影响 拟议的研究计划将为吉布森博士采取下一步行动做好准备。 在独立临床试验中研究这些症状的治疗方法非常有效。 常见于 HD 和 PD，给患者和护理人员造成重大负担，不幸的是，这种方法的作用有限。 有关如何治疗这些症状的证据 专家建议使用心理干预措施来治疗。 HD 和 PD 中存在焦虑症状，但很少有严格的研究来支持这些建议。 针对解释偏差的认知偏差修正（CBM-I）范式通过以下方式解决负面解释偏差： 训练参与者以更温和的方式（重新）解释模棱两可的、潜在威胁的情况 我们的前期工作证明了基于网络的CBM-I在这方面的可行性。 人口，并确定需要调整 CBM-I 计划以满足行动不便的个人的需求 我们当前的目标是确定基于网络的认知偏差是否可以修正。 解释偏差 (CBM-I) 干预可以减少 PD 和 HD 的焦虑，因此，我们的目标是：1) 收集。 利益相关者的观点和 2) 开发基于网络的 CBM-I 干预措施，适合患有以下疾病的个人 神经退行性运动障碍（MindTrails-Movement），然后 3) 评估目标参与度和 MindTrails-Movement 对减少 HD 和 HD 患者的解释偏差和焦虑症状的初步效果 PD：实现这些目标并使吉布森博士成为制定干预措施的国家领导者。 对于神经退行性疾病的神经精神症状管理，她将与专家合作 由 Bethany Teachman 博士领导的指导团队，包括共同导师 Madaline Harrison、Carol 博士。 曼宁（Manning）、珍妮·阿尔胡森（Jeanne Alhusen）和严国芬（Guofen Yan）的培训经验将为吉布森博士的职业生涯提供支持。 发展目标：1) 培养使用以人为本的设计开发行为干预措施的技能；2) 培养临床试验设计和实施方面的专业知识；3) 建立先进的机制知识； 维持情绪和焦虑障碍；4) 培养领导力和资助技能并建立 合作为弗吉尼亚大学独立护士科学家的成功职业生涯做好准备。 为实现这些研究和职业发展目标提供了理想的环境，作为世界的家园- 类护理学校、亨廷顿病卓越中心、美国帕金森病协会 高级研究中心和焦虑、认知和治疗计划 (PACT) 实验室 - 所有这些 对于该提案的成功至关重要。