Wake Forest Translational Alcohol Research Center (WF-TARC)

维克森林转化酒精研究中心 (WF-TARC)

• 批准号: 10526640
• 负责人: JEFFREY L WEINER
• 金额: $ 160.03万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-10 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526640
• 关键词: Acceleration; Adolescent; Alcohol consumption; Alcohols; Animal Model; Animals; Award; Behavior; Behavioral; Biometry; Brain; Collaborations; Communication; Community Health Education; Development; Diagnosis; Disease; Education; Education and Outreach; Ensure; Experimental Designs; Faculty; Funding; Goals; Grant; Growth; Healthcare Systems; Human; Human Subject Research; Individual; Infrastructure; Institution; Knowledge; Leadership; Learning; Measures; Methods; Molecular; Neurobiology; Pilot Projects; Play; Population; Populations at Risk; Postdoctoral Fellow; Pre-Clinical Model; Productivity; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Rodent; Role; Science; Sleep disturbances; Students; Substance Use Disorder; System; Talents; Translational Research; Translations; Treatment outcome; Work; addiction; alcohol abuse therapy; alcohol research; alcohol use disorder; behavioral study; drinking behavior; educational atmosphere; effective therapy; evidence base; forest; human model; improved; innovation; medical schools; morphogens; multidisciplinary; neural; neural correlate; neurodevelopment; next generation; nonhuman primate; novel; novel strategies; novel therapeutic intervention; predictive modeling; programs; recruit; resilience; success; training opportunity; translational therapeutics

WAKE FOREST TRANSLATIONAL ALCOHOL RESEARCH CENTER (WF-TARC) OVERALL SUMMARY The central goal of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to employ integrated, translational animal and human subjects research to study behavioral correlates and neurobiological substrates associated with vulnerability and resilience to alcohol use disorder (AUD). This Center builds on a highly productive translational alcohol research program at WFSM that led to the awarding of this P50 grant in 2017. The WF-TARC is comprised of four research projects and two cores. An administrative core provides the leadership and infrastructure needed to ensure integration across all research projects. This core also provides biostatistical support and promotes interactions and communication between this Center and the many other addiction-related research and educational programs at Wake Forest School of Medicine (WFSM). A pilot project core serves to advance the goals and objectives of the WF-TARC. This core funds projects each year to attract new investigators to bring their talent and expertise to the study of AUD vulnerability. The unifying research focus of the WF-TARC is to leverage the unique strengths and advantages of animal and human subjects research to study behavioral correlates of AUD vulnerability and identify neurobiological adaptations that contribute to this heightened risk of developing this disorder. These studies employ cutting- edge, multidisciplinary experimental approaches spanning molecular, cellular, circuit, and whole-brain analyses. Importantly, studies in each project are also seeking to improve AUD treatment outcomes. The well- integrated conceptual framework and research design facilitates backward and forward interactions across all projects, facilitating the rapid translation of therapeutic discoveries from animals to humans. The WF-TARC leverages a well-established, highly collaborative translational alcohol research program at WFSM and benefits from a strong and growing institutional focus on alcohol and substance use disorders. This Center will continue to enhance the outstanding educational environment at our institution, providing unique training opportunities for the students and postdoctoral who will become the next generation of translational alcohol researchers. Finally, the innovative research supported by the WF-TARC may lead to improved evidence-based therapies for individuals who are at greatest risk of developing AUD, individuals who are particularly ill-served by current AUD treatment options.

Wake Forest转化酒精研究中心（WF-TARC） 总结 Wake Forest转化酒精研究中心（WF-TARC）的核心目标是采用 综合，转化的动物和人类受试者研究行为相关的研究和 神经生物学基质与脆弱性和对酒精使用障碍的韧性相关（AUD）。这 中心建立在WFSM高产的转化酒精研究计划的基础上，这导致了奖励 2017年的P50赠款。 WF-TARC由四个研究项目和两个核心组成。行政核心提供 领导和基础设施需要确保所有研究项目的整合。此核心也提供 生物统计支持并促进该中心与其他许多其他人之间的互动和沟通 Wake Forest医学院（WFSM）与成瘾有关的研究和教育计划。飞行员 Project Core有助于促进WF-TARC的目标。该核心每年为项目提供资金 吸引新的调查人员将他们的才华和专业知识带入AUD脆弱性研究。 WF-TARC的统一研究重点是利用动物的独特优势和优势 人类受试者研究研究AUD脆弱性的行为相关性并确定神经生物学 适应导致这种疾病的风险增加的改编。这些研究采用了剪裁 - 边缘，多学科实验方法涵盖分子，细胞，电路和全脑 分析。重要的是，每个项目的研究也在寻求改善AUD治疗结果。福 整合的概念框架和研究设计促进了所有人的向后和向前互动 项目，促进了从动物到人类的治疗发现的快速翻译。 WF-TARC利用了一个完善的，高度协作的翻译酒精研究计划 WFSM和受益于酒精和物质使用障碍的强大而不断增长的机构受益。 该中心将继续改善我们机构的杰出教育环境，提供 为学生和博士后的独特培训机会，他们将成为下一代 转化酒精研究人员。最后，WF-TARC支持的创新研究可能导致 改进了针对患有AUD风险最大的个人的循证疗法， 当前的AUD治疗选择尤其不利。