Wake Forest Translational Alcohol Research Center (WF-TARC)

维克森林转化酒精研究中心 (WF-TARC)

基本信息

批准号：
10310693
负责人：
JEFFREY L WEINER
金额：
$ 160.29万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-10 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10310693
关键词：
Adolescence Adolescent Alcohol consumption Alcohol dependence Alcoholism Alcohols Animal Model Animals Anxiety Behavior Biological Biometry Brain Cessation of life Childhood Clinical Communication Communities Data Development Diagnosis Disease Drug Addiction Early Diagnosis Ensure Environment Experimental Designs Experimental Models Faculty Funding Goals Grant Healthcare Systems Human Human Subject Research Individual Infrastructure Institution Interdisciplinary Study Intervention Investments Lead Leadership Learning Link Methods Modeling Molecular Monkeys National Institute on Alcohol Abuse and Alcoholism Neurobiology Pilot Projects Populations at Risk Postdoctoral Fellow Prevalence Publishing Relapse Research Research Design Research Methodology Research Personnel Research Project Grants Resistance Resources Risk Rodent Students Substance Addiction Talents Therapeutic Therapeutic Intervention Training Translational Research Translations United States Vulnerable Populations addiction alcohol misuse alcohol related problem alcohol research alcohol use disorder behavioral study cost critical period educational atmosphere endophenotype epidemiology study evidence base forest human model innovation medical schools multidisciplinary neural circuit neuroadaptation neurobehavioral next generation nonhuman primate novel novel therapeutic intervention problem drinker programs recruit relating to nervous system resilience responsible alcohol use socioeconomics stressor substance use success therapeutically effective training opportunity

Adolescence Adolescent Alcohol consumption Alcohol dependence Alcoholism Alcohols Animal Model Animals Anxiety Behavior Biological Biometry Brain Cessation of life Childhood Clinical Communication Communities Data Development Diagnosis Disease Drug Addiction Early Diagnosis Ensure Environment Experimental Designs Experimental Models Faculty Funding Goals Grant Healthcare Systems Human Human Subject Research Individual Infrastructure Institution Interdisciplinary Study Intervention Investments Lead Leadership Learning Link Methods Modeling Molecular Monkeys National Institute on Alcohol Abuse and Alcoholism Neurobiology Pilot Projects Populations at Risk Postdoctoral Fellow Prevalence Publishing Relapse Research Research Design Research Methodology Research Personnel Research Project Grants Resistance Resources Risk Rodent Students Substance Addiction Talents Therapeutic Therapeutic Intervention Training Translational Research Translations United States Vulnerable Populations addiction alcohol misuse alcohol related problem alcohol research alcohol use disorder behavioral study cost critical period educational atmosphere endophenotype epidemiology study evidence base forest human model innovation medical schools multidisciplinary neural circuit neuroadaptation neurobehavioral next generation nonhuman primate novel novel therapeutic intervention problem drinker programs recruit relating to nervous system resilience responsible alcohol use socioeconomics stressor substance use success therapeutically effective training opportunity

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项目摘要

PROJECT SUMMARY The central goal of the Wake Forest Translational Alcohol Research Center (WF-TARC) is to employ animal models and human subjects research to study behavioral and neurobiological substrates associated with vulnerability (and resilience) to alcohol use disorder (AUD). This Center builds on a highly productive translational alcohol research program at WFSM that was recently established with NIAAA developmental program project (P01) support. The WF-TARC will have four research projects and two cores. An administrative core will provide the leadership and infrastructure needed to ensure integration across all research projects, provide biostatistical support, and promote interactions and communication between this Center and the many other addiction- related research and educational programs at Wake Forest School of Medicine (WFSM). A pilot project core will be established to advance the goals and objectives of the WF-TARC. This core will fund four projects each year to attract new investigators to bring their talent and expertise to the study of AUD vulnerability. The unifying research focus of the WF-TARC will be to leverage the strengths and advantages of animal models and human subjects research to study behavioral correlates of AUD vulnerability and identify neurobiological adaptations that contribute to this heightened risk of developing AUD. Studies will employ cutting-edge, multidisciplinary experimental approaches spanning molecular, cellular, circuit, and whole-brain analyses. Importantly, each project will evaluate novel interventions targeted at the reversing the maladaptive neural adaptations that promote AUD vulnerability. The highly-integrated conceptual framework and research design will facilitate backward and forward interactions between the projects, facilitating the rapid translation of therapeutic discoveries from animals to humans. The WF-TARC takes advantage of a well-established, extremely collaborative translational alcohol research program at WFSM and will benefit from a strong and growing institutional focus on alcohol and drug addiction research. This Center will further enhance the outstanding educational environment at our institution, providing unique training opportunities for the students and postdoctoral who will become the next generation of translational alcohol researchers. Finally, the innovative research that will be supported by the WF-TARC may lead to better evidence-based therapies for individuals who are at greatest risk of developing AUD, individuals who are particularly ill-served by current AUD treatment options.

项目摘要 Wake Forest转化酒精研究中心（WF-TARC）的核心目标是雇用动物模型和人类受试者研究与相关的行为和神经生物学基质脆弱性（和弹性）对酒精使用障碍（AUD）。这个中心以高产性为基础 WFSM的转化酒精研究计划最近通过NIAAA发展而建立计划项目（P01）支持。 WF-TARC将有四个研究项目和两个核心。行政核心将提供确保在所有研究项目中整合，提供生物统计学的领导和基础设施支持，并促进该中心与许多其他成瘾之间的互动和沟通 - Wake Forest医学院（WFSM）的相关研究和教育计划。试点项目核心将建立以促进WF-TARC的目标。该核心将资助四个项目一年来吸引新的调查人员将他们的才华和专业知识带入AUD脆弱性的研究。 WF-TARC的统一研究重点是利用动物的优势和优势模型和人类受试者研究研究AUD脆弱性的行为相关性并确定神经生物学适应导致这种AUD的风险增加。研究将采用跨越分子，细胞，电路和全脑的尖端，多学科实验方法分析。重要的是，每个项目都将评估针对反向不良适应性的针对逆转的新颖干预措施神经适应性促进aud脆弱性。高度集成的概念框架和研究设计将促进项目之间的向后和向前互动，从而促进从动物到人类的治疗发现。 WF-TARC利用了建立了良好的，极其协作的转化性酒精研究 WFSM的计划，将受益于对酒精和吸毒成瘾的强大而不断增长的机构的关注研究。该中心将进一步改善我们机构的杰出教育环境，提供为学生和博士后的独特培训机会，他们将成为下一代转化酒精研究人员。最后，WF-TARC将支持的创新研究为患有最大风险的个人提供更好的循证疗法，个人，个人当前AUD治疗方案的人数尤其不佳。