Assessment of approach-avoidance motivation in neuropsychiatric disorders

神经精神疾病的接近-回避动机评估

• 批准号: 10503869
• 负责人: MICHAEL W. SCHLUND
• 金额: $ 74.86万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10503869
• 关键词: Acute; Adult; Affect; Affective; Age; Anhedonia; Anterior; Anxiety; Area; Behavior; Behavioral; Behavioral Paradigm; Brain; Characteristics; Clinical assessments; Cognition; Cognitive; Conflict (Psychology); Corpus striatum structure; Data; Development; Diagnostic; Disease; Distress; Dose; Ecological momentary assessment; Emotional; Exhibits; Foundations; Frequencies; Fright; Functional disorder; Future; Goals; Human; Image; Individual; Instruction; Insula of Reil; Investigation; Life; Matched Group; Measurement; Measures; Mental Depression; Mental Health; Methodology; Modeling; Moods; Motivation; Negative Valence; Outcome; Participant; Persons; Positive Valence; Probability; Property; Psychometrics; Psychoses; Regression Analysis; Reporting; Research; Research Domain Criteria; Research Project Grants; Rewards; Severities; Sex Differences; Standardization; System; Testing; Time; Validity and Reliability; Visual; Work; anxious; approach avoidance behavior; approach behavior; avoidance behavior; base; behavioral response; clinically significant; cognitive control; design; emotion regulation; flexibility; innovation; neuroimaging; neuropsychiatric disorder; psychosocial; public health research; recruit; relating to nervous system; response; social; social anxiety; social learning; stem; theories; user-friendly

ABSTRACT PAR-18-30 “Development and Optimization of Tasks and Measures for Functional Domains of Behavior” encourages research projects that will develop and optimize new or existing tasks and measures for the Research Domain Criteria (RDoC). This call stems from workgroups of the National Advisory Mental Health Council that identified significant gaps in the RDoC measurement toolkit. In the negative valence systems (NVS) domain, one priority area is the need for behavioral paradigms for identifying areas of overlap and distinction between NVS, which motivate defensive avoidance behaviors, and positive valence systems (PVS), which motivate reward-approach behaviors. We contend that approach-avoidance (AP-AV) paradigms offer a promising solution. AP-AV tasks are essentially behavioral approach tests that enable assessment of overt behavioral responses to acute threats. The aims of this proposal are to demonstrate the (1) psychometric adequacy (test-retest reliability) and (2) diagnostic/predictive validity of a user-friendly instructed AP-AV-task we’ve developed for assessing psychosocial dysfunction associated with anxiety, depression, psychosis, and other conditions. Our aims build upon extensive preliminary research in our lab devoted to optimizing task parameters, measures and administration. This work has the potential to yield an easy-to-use and widely disseminable AP-AV task for identifying areas of overlap and distinction between NVS and PVS, as well as a general AP-AV methodology that is adaptable for assessing overt behavioral responses to acute threats. To achieve these aims, we will recruit three matched groups of adults (healthy, elevated social anxiety, and elevated social anhedonia). Inclusion of groups with anxiety and anhedonia are necessary to assess diagnostic and predictive validity. Participants will complete standardized clinical assessments and complete the instructed AP-AV task multiple times during two neuroimaging sessions, separated by 10-14 days. Between imaging sessions, ecological momentary assessments (EMA) will capture mood, motivational level, frequency of real-life approach/avoidance, and emotional regulation strategy use. This research is theoretically significant because it highlights the relevance of theories of AP-AV motivation for research devoted to identifying areas of overlap and distinction between NVS and PVS. This research is methodologically innovative because it will produce a user-friendly AP-AV task with strong psychometric properties for use in behavioral (stand-alone) or neuroimaging research. Outcome data will also provide the necessary empirical foundation for future investigations into the suitability of AP-AV tasks for use with individuals who vary widely in age, ability, and/or severity of disorder.

抽象的 PAR-18-30“行为功能领域的任务和措施的发展和优化” 鼓励研究项目，这些项目将开发和优化新的或现有的任务和措施 研究领域标准（RDOC）。该呼叫从国家咨询心理健康工作组的步骤 理事会确定了RDOC测量工具包中的巨大差距。在负价系统（NVS）中 领域，优先区域是需要行为范式来识别重叠和区别的领域 在NV之间，这种动机防御性避免行为和正价系统（PVS）， 哪些激励性奖励诉诸行为。我们认为这种避免接近（AP-AV）范例 提供承诺解决方案。 AP-AV任务本质上是行为方法测试，可实现评估 公开对急性威胁的行为反应。该提议的目的是证明（1） 心理测量适中（测试可靠性）和（2）用户友好的诊断/预测有效性 我们开发了用于评估与动画相关的社会心理功能障碍的指示AP-AV任务 抑郁，精神病和其他疾病。我们的目标是基于我们的广泛初步研究 实验室致力于优化任务参数，度量和管理。这项工作有可能 产生易于使用的且广泛分发的AP-AV任务，以识别重叠和区别的领域 在NV和PV之间以及适用于公开的一般AP-AV方法论 行为对急性威胁的反应。为了实现这些目标，我们将招募三个匹配的成年人组 （健康，升高的社交焦虑和升高的社交狂欢）。包括动画和 Anhedonia对于评估诊断和预测有效性是必要的。参与者将完成 标准化的临床评估，并在两次期间完成多次指示的AP-AV任务 神经影像学会议，分别为10-14天。在成像会议之间，生态瞬间 评估（EMA）将捕捉情绪，动机水平，现实生活中的方法/避免的频率， 和情感调节策略的使用。这项研究在理论上具有重要意义，因为它突出了 AP-AV动机理论的相关性，用于识别重叠和区分领域的研究 在NV和PV之间。这项研究在方法论上具有创新性，因为它将产生一个用户友好的 AP-AV任务具有强大的心理测量特性，用于行为（独立）或神经影像学 研究。结果数据还将为未来研究的必要经验基础提供 AP-AV任务适合与年龄，能力和/或疾病严重程度相差很大的个人使用。