BOLD FMRI IN MR RESEARCH TO MAP LEARNING HISTORIES

MR 研究中大胆的 FMRI 绘制学习历史

• 批准号: 7378956
• 负责人: MICHAEL W. SCHLUND
• 金额: $ 0.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378956
• 关键词: BOLD; FMRI; MR; RESEARCH; MAP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposal is to evaluate a visuomotor task as a model for understanding the physiology of aging in health and sickness. We will compare the findings from healthy subjects with those undergoing estrogen replacement therapy (ERT) and older subjects with Parkinson's disease (PD) and macular degeneration (MD). We evaluate the visuomotor system to gain a detailed understanding of this input-output sensorimotor loop and because deficits in this system can lead to significant morbidity in the elderly from falls and motor vehicle accidents. Also, the neuro-degenerative disorders we are studying have manifestations in the visual and motor systems. We wish to obtain pilot data for an NIH program project grant on these subjects.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。该提案的总体目标是评估视觉运动任务作为理解健康和疾病衰老生理学的模型。我们将比较健康受试者与接受雌激素替代疗法 (ERT) 的受试者以及患有帕金森病 (PD) 和黄斑变性 (MD) 的老年受试者的研究结果。我们评估视觉运动系统，以便详细了解这种输入-输出感觉运动回路，因为该系统的缺陷可能导致老年人因跌倒和机动车事故而显着发病。此外，我们正在研究的神经退行性疾病在视觉和运动系统中都有表现。我们希望获得关于这些主题的 NIH 计划项目拨款的试点数据。