Practice Core

实践核心

• 批准号: 10493443
• 负责人: Maureen Sanderson
• 金额: $ 34.62万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493443
• 关键词: Address; Area; Behavioral Sciences; Biometry; Breast; Breast Cancer Risk Factor; Cancer Center; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Community Developments; Conduct Clinical Trials; Continuity of Patient Care; Coupled; Data; Disease; Early Diagnosis; Educational Materials; Enrollment; Epidemiology; Etiology; Evaluation; Exclusion Criteria; Experimental Designs; Future; General Hospitals; Goals; Health; Healthcare; Incidence; Information Dissemination; Infrastructure; Institution; Intervention; Intervention Trial; Investigator-Initiated Research; Learning; Link; Logic; Longitudinal cohort; Lung; Malignant Neoplasms; Mentorship; Methods; Minority Access; Mission; Modeling; Observational Study; Oncology; Outcome; Palliative Care; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Population Research; Population Sciences; Prevention; Public Hospitals; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Risk Assessment; Risk Factors; Science; Screening for cancer; Self Management; Students; Supportive care; Tennessee; Therapeutic Clinical Trial; Time; Training; Trust; Underserved Population; Universities; Woman; Work; anticancer research; base; behavioral health; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer therapy; care delivery; clinical infrastructure; cohort; community engaged research; community engagement; comorbidity; control trial; design; education research; ethnic minority; improved; inclusion criteria; lung cancer screening; malignant breast neoplasm; medical schools; metropolitan; mortality; neoplasm registry; outreach; patient population; population based; pre-doctoral; prospective; racial minority; recruit; research study; safety net; success; survivorship; tobacco control; trial design

PROJECT SUMMARY: POPULATION RESEARCH AND CLINICAL TRIALS IN CANCER EQUITY (PRACTICE) SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, it is incumbent upon us to augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. Therefore, we propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University (TSU) and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is also a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Shared Resource Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum. This can be broadly categorized into three thematic domains focused on decreasing cancer health disparities: 1) prevention and early detection; 2) interventional trials and observational studies during and following cancer treatment; and 3) implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Shared Resource Core will address the following specific aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目摘要：癌症公平的人口研究和临床试验 （实践）共享资源核心 拟议的人口研究和癌症公平（实践）共享资源核心的临床试验 将建立在现有的临床试验核心（CTC）的基础设施基础上 Meharry/Vanderbilt-Ingram癌症中心/田纳西州立大学癌症伙伴关系（MVTCP） 它的成立。尽管CTC一直在将临床试验带到纳什维尔的患者基础上 Meharry医学院（MMC）的综合医院（NGH），更完全解决癌症健康 差异，我们有责任通过预防，早期发现， 纳什维尔大都会统计区（MSA）的治疗，生存和姑息治疗，由 我们的伙伴关系。因此，我们建议建立实践共享资源核心，以进一步 受益于NGH患者基础，促进研究人员发起的研究并扩大伙伴关系的影响力 到纳什维尔MSA的服务不足。 MVTCP在人口科学研究中具有很大的力量 这将增强临床研究的现有力量。例子包括由MMC领导的研究 田纳西州立大学（TSU）和范德比尔特 - 伊格兰癌症中心（VICC）研究人员与 全州癌症登记处招募乳腺癌的病因研究，早期的肺癌筛查试验 检测，在服务不足的烟草控制试验中，加强了参与者招募癌症研究和 与癌症外展核心和转化病理共享的生物测量收集 资源核心。在进行治疗临床试验的情况下，还有丰富的历史 VICC的临床试验办公室（CTO）和NGH的CTO。实践的总体任务共享 资源核心是增强对治疗临床试验的应计，同时扩大少数族裔的访问权限和 服务欠佳的患者在整个癌症护理连续体中进行研究。实践分享了 资源核心与医学博士露西·斯帕卢托（Lucy Spalluto）在她提议的项目的起源中进行了广泛合作，以研究该项目 在服务不足的妇女中实施乳腺癌风险评估。我们将协助实施 这项研究和结果传播。我们的核心还将支持其他基于临床和人群的科学 跨癌症护理连续性的研究。这可以将其广泛分为三个主题领域 专注于减少癌症健康差异：1）预防和早期检测； 2）介入试验和 癌症治疗期间和之后的观察性研究； 3）实施医疗干预措施 改善癌症护理的分娩。实践共享资源核心将解决以下特定目标： 1）扩大与患者基础有关的治疗临床试验和癌症控制研究的组合 NGH在Meharry和Nashville MSA； 2）在梅哈里（Meharry）的NGH开发癌症队列，以作为一种资源 在癌症护理连续体中进行未来的研究； 3）为临床学员提供培训和指导 在进行临床试验以及在研究中招募和保留率低的人群中。