Practice Core

实践核心

基本信息

批准号：
10705109
负责人：
Maureen Sanderson
金额：
$ 34.62万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705109
关键词：
Address Area Behavioral Sciences Biometry Breast Breast Cancer Risk Factor Cancer Center Cancer Control Categories Clinical Clinical Research Clinical Trials Collaborations Collection Communities Community Developments Conduct Clinical Trials Continuity of Patient Care Coupled Data Disease Disparity Early Diagnosis Educational Materials Eligibility Determination Enrollment Epidemiology Equity Etiology Evaluation Exclusion Exclusion Criteria Experimental Designs Future General Hospitals Goals Health Healthcare Incidence Information Dissemination Infrastructure Institution Intervention Intervention Trial Investigator-Initiated Research Learning Link Logic Longitudinal cohort Lung Malignant Neoplasms Mentorship Methods Minority Access Mission Modeling Observational Study Oncology Outcome Palliative Care Participant Pathology Patient Recruitments Patient-Focused Outcomes Patients Population Research Population Sciences Prevention Public Hospitals Recording of previous events Research Research Personnel Research Project Grants Research Support Resource Sharing Resources Risk Risk Assessment Risk Factors Science Screening for cancer Self Management Supportive care Tennessee Therapeutic Clinical Trial Time Training Trust Underserved Population Universities Woman Work anticancer research base behavioral health cancer care cancer diagnosis cancer health disparity cancer subtypes cancer therapy care delivery clinical infrastructure clinical training cohort community engaged research community engagement comorbidity control trial design doctoral student education research ethnic minority improved inclusion criteria lung cancer screening malignant breast neoplasm medical schools metropolitan mortality neoplasm registry outreach patient population population based pre-doctoral prospective racial minority recruit research study safety net success survivorship tobacco control trial design

项目摘要

PROJECT SUMMARY: POPULATION RESEARCH AND CLINICAL TRIALS IN CANCER EQUITY (PRACTICE) SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, it is incumbent upon us to augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. Therefore, we propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University (TSU) and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is also a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Shared Resource Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum. This can be broadly categorized into three thematic domains focused on decreasing cancer health disparities: 1) prevention and early detection; 2) interventional trials and observational studies during and following cancer treatment; and 3) implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Shared Resource Core will address the following specific aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目摘要：癌症公平的人口研究和临床试验（实践）共享资源核心拟议的人口研究和癌症公平（实践）共享资源核心的临床试验将建立在现有的临床试验核心（CTC）的基础设施基础上 Meharry/Vanderbilt-Ingram癌症中心/田纳西州立大学癌症伙伴关系（MVTCP）它的成立。虽然CTC一直在将临床试验带到纳什维尔的患者基础上 Meharry医学院（MMC）的综合医院（NGH），更完全解决癌症健康差异，我们有责任通过预防，早期发现，纳什维尔大都会统计区（MSA）的治疗，生存和姑息治疗，由我们的伙伴关系。因此，我们建议建立实践共享资源核心，以进一步受益于NGH患者基础，促进研究人员发起的研究并扩大伙伴关系的影响力到纳什维尔MSA的服务不足。 MVTCP在人口科学研究中具有很大的力量这将增强临床研究的现有力量。例子包括由MMC领导的研究田纳西州立大学（TSU）和范德比尔特 - 伊格兰癌症中心（VICC）研究人员与全州癌症登记处招募乳腺癌的病因研究，早期的肺癌筛查试验检测，在服务不足的烟草控制试验中，加强了参与者招募癌症研究和与癌症外展核心和转化病理共享的生物测量收集资源核心。在进行治疗临床试验的情况下，还有丰富的历史 VICC的临床试验办公室（CTO）和NGH的CTO。实践的总体任务共享资源核心是增强对治疗临床试验的应计，同时扩大少数族裔的访问权限和服务欠佳的患者在整个癌症护理连续体中进行研究。实践分享了资源核心与医学博士露西·斯帕卢托（Lucy Spalluto）在她提议的项目的起源中进行了广泛合作，以研究该项目在服务不足的妇女中实施乳腺癌风险评估。我们将协助实施这项研究和结果传播。我们的核心还将支持其他基于临床和人群的科学跨癌症护理连续性的研究。这可以将其广泛分为三个主题领域专注于减少癌症健康差异：1）预防和早期检测； 2）介入试验和癌症治疗期间和之后的观察性研究； 3）实施医疗干预措施改善癌症护理的分娩。实践共享资源核心将解决以下特定目标： 1）扩大与患者基础有关的治疗临床试验和癌症控制研究的组合 NGH在Meharry和Nashville MSA； 2）在梅哈里（Meharry）的NGH开发癌症队列，以作为一种资源在癌症护理连续体中进行未来的研究； 3）为临床学员提供培训和指导在进行临床试验以及在研究中招募和保留率低的人群中。