Increasing HPV Vaccine Utilization Among African-Amerian Girls Through Social...

通过社会活动提高非裔美国女孩 HPV 疫苗的使用率

基本信息

批准号：
8534735
负责人：
Maureen Sanderson
金额：
$ 4.36万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8534735
关键词：
Address African African American Age Attitude Belief Cancer Etiology Caregivers Cervical Cervical Cancer Screening Church Clinic Clinical Trials Communities Community based prevention Data Aggregation Data Sources Daughter Disease Dose Enrollment Family Feedback Focus Groups Genital system Human Papilloma Virus Vaccine Human Papillomavirus Human papillomavirus 16 Human papillomavirus 18 Immunization Incidence Individual Infection Infection prevention Intervention Interview Knowledge Malignant Neoplasms Malignant neoplasm of cervix uteri Marketing Modeling Modification Outreach Research Pap smear Parents Phase Pilot Projects Population Premalignant Public Health Radio Registries Research Research Project Grants Schools Series Social Marketing Surveys Techniques Television Testing Text The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Time Vaccination Vaccines Woman base cancer health disparity cohort community based participatory research evidence base girls high risk mortality outreach prevent prototype social theories uptake

项目摘要

Despite increases in cervical cancer screening in the past few decades, African American women have substantially higher rates of cervical cancer incidence and mortality than white women. Persistent infection with high-risk types 16 and 18 of human papillomavirus (HPV) is known to cause 70% of cervical cancers. Since 2006 the FDA has approved two vaccines developed to prevent cervical cancer caused by these high-risk types of genital HPV. Clinical trials have demonstrated these vaccines to be nearly 100% efficacious in preventing infection of HPV types 16 and 18, precancerous cervical disease, and resulting cervical cancer. According to the 2009 National Immunization Survey, rates of initiation of the HPV vaccine were similar for African American and white girls (44%), but rates of completion of the three required doses were lower for African American versus White girls (23% and 29%, respectively). Increasing uptake and completion of the HPV vaccine series among African American girls will reduce rates of cervical cancer among African American women, which in combination with continued Pap testing, can eventually reduce racial disparities in cervical cancer. As a hypothesis-driven research project under the Cancer Outreach Core, we propose to develop and test the feasibility and impact of a culturally-appropriate social marketing intervention targeting African American girls and their parents to increase utilization and completion of the HPV vaccine series. The proposed project follows the model of Community-Based Prevention Marketing as described by Bryant and colleagues, which combines social marketing theories and techniques with community-based participatory research approaches to guide the planning and implementation of evidence-based strategies for addressing public health concerns.

尽管过去几十年来宫颈癌筛查增加了，但非洲裔美国妇女还是宫颈癌发病率和死亡率比白人女性高得多。已知人乳头瘤病毒（HPV）的高危16和18的持续感染可引起70％的宫颈癌。自2006年以来，FDA已批准开发出两种疫苗，以预防由这些高风险的生殖器HPV引起的宫颈癌。临床试验表明，这些疫苗在防止感染HPV 16和18，癌前颈疾病和由此导致的宫颈癌的感染方面有效近100％。根据2009年的全国免疫调查，非裔美国人和白人女孩的HPV疫苗开始率相似（44％），但三种必需剂量的完成率较低，而非洲裔美国人对白人女孩和白人女孩（分别为23％和29％）。非洲裔美国女孩中HPV疫苗系列的摄取和完成的摄取和完成将降低非洲裔美国妇女的宫颈癌发生率，这些妇女与持续的PAP测试结合使用，最终可以减少宫颈癌的种族差异。作为癌症外展核心下的假设驱动的研究项目，我们建议开发和测试针对非裔美国人女孩及其父母的文化适当的社会营销干预措施的可行性和影响，以增加HPV疫苗系列的利用和完成。拟议的项目遵循布莱恩特及其同事所描述的基于社区的预防营销模型，该项目将社会营销理论和技术与基于社区的参与研究方法相结合，以指导和实施基于证据的策略来解决公共卫生问题。