Understanding breast cancer subtypes in Black women

了解黑人女性乳腺癌亚型

• 批准号: 9102023
• 负责人: Maureen Sanderson
• 金额: $ 7.83万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9102023
• 关键词: Address; Age; Age at Menarche; Breast; Breast Cancer Risk Factor; Breast Feeding; Cancer Etiology; Case-Control Studies; Cessation of life; Classification; Clinical; Collection; Contraceptive Usage; Development; Diagnosis; Disease; Epidermal Growth Factor Receptor; Estrogen Receptors; Etiology; Factor Analysis; Fluorescent in Situ Hybridization; Future; Gene Expression Profiling; Health; Hormone Receptor; Hormone replacement therapy; Hormones; Human; Immunohistochemistry; Incidence; Knowledge; Malignant Neoplasms; Mammary Neoplasms; Menopause; Modeling; Obesity; Oral Contraceptives; Outcome; Participant; Physical activity; Process; Progesterone Receptors; Race; Reporting; Risk; Risk Factors; South Carolina; Specimen; Staging; Tennessee; Term Birth; Tissue Sample; Tumor Markers; Tumor Subtype; Tumor Tissue; Woman; age group; base; cancer diagnosis; cancer subtypes; experience; immunohistochemical markers; malignant breast neoplasm; modifiable risk; molecular subtypes; mortality; outcome forecast; parity; population based; racial difference; screening; triple-negative invasive breast carcinoma

 DESCRIPTION (provided by applicant): Little is understood about what factors might explain why Black women tend to be diagnosed with more aggressive disease than White women. Based on characterization by immunohistochemical (IHC) markers, in every age group, White women have the highest rates of estrogen receptor (ER)+ breast cancer and Black women have the highest rates of ER- breast cancer. Moreover, triple negative breast cancer [TNBC; ER-, progesterone receptor (PR)-, human epidermal growth factor receptor 2 (HER2)-], an aggressive subset of basal-like breast cancer, is more common among Black women than among White women and has a worse prognosis than other subtypes. Recent studies, conducted largely among White women, have reported differences in risk by breast cancer subtype associated with hormone-related and other risk factors, such as age at menarche, oral contraceptive use, parity, age at first full-term birth, breastfeeding, age at menopause, hormone replacement therapy use, obesity and physical activity, suggesting that subtypes of breast tumors may have distinct etiologies. Few breast cancer studies have included large numbers of Black women, despite known marked racial differences in cancer incidence by subtype, and most studies did not collect tumor tissue to allow for detailed characterization of tumor subtypes. To address this issue, we propose to collect tumor tissue specimens from 710 Black breast cancer cases, to classify breast tumors by hormone-receptor status, and to examine associations between hormone-related and other risk factors and breast cancer subtypes among Black women. The association of breast cancer with many modifiable risk factors appears to differ by tumor subtype; therefore, it is essential to perform subtyping of all breast tumors in future studies. The utilization of a soon to be completed population-based case-control study of Black women is a highly efficient approach to the collection and classification of breast cancer tumor tissue since we have already obtained participants' permission. This proposed project will be one of the most comprehensive and well-powered studies to investigate the associations between hormone-related and other risk factors and breast cancer subtypes among Black women. Moreover, the collection of tumor tissue will provide immediate future opportunities to extend these risk factor analyses to intrinsic molecular subtypes. The results of this study will fill an important gap in current knowledge regarding assessment of hormone-related factors that increase risk for aggressive breast cancer among Black women, and will assist in delineating Black women at high (or low) risk for breast cancer subtypes with a poor prognosis who will most benefit from screening, and may provide new targets to reduce the risk of aggressive breast cancer among Black women. This may pave the way for the development of clinically useful breast cancer prediction models specific to race and breast cancer subtype.

 描述（由适用提供）：关于哪些因素可能解释了为什么黑人妇女往往比白人妇女更具侵略性疾病的原因了解了什么因素。根据免疫组织化学（IHC）标记的特征，在每个年龄段中，白人妇女的雌激素受体（ER）+乳腺癌和黑人妇女的率最高。此外，三重阴性乳腺癌[TNBC; ER-，孕激素受体（PR） - ，人类表皮生长因子受体2（HER2） - ]是碱性乳腺癌的积极子集，在黑人妇女中比白人女性更为常见，并且比其他亚型的预后更差。最近在白人妇女中进行的研究报告了与马相关和其他风险因素相关的乳腺癌亚型的风险差异，例如初潮时代的年龄，口服避孕药使用，均等，初期出生时的年龄，母乳喂养，更年期的年龄，更年期的年龄，骑马疗法的使用，肥胖治疗，肥胖，肥胖，肥胖和体育锻炼，表现出术语的不同图像。尽管已知通过亚型在癌症发生率上明显的种族差异，但很少有乳腺癌研究包括大量黑人妇女，并且大多数研究未收集肿瘤组织以允许详细的肿瘤亚型表征。 为了解决这个问题，我们建议从710例黑色乳腺癌病例中收集肿瘤组织标本，通过骑马受体状态对乳腺肿瘤进行分类，并检查黑人女性与骑马有关的危险因素和其他危险因素与乳腺癌亚型之间的关联。乳腺癌与许多可修改的危险因素的关联似乎与肿瘤亚型不同。因此，在未来的研究中，必须对所有乳腺肿瘤进行亚型。对即将完成的黑人妇女的基于人群的病例对照研究的利用是一种高效的收集和分类方法 由于我们已经获得了参与者的许可，因此乳腺癌肿瘤组织。该拟议的项目将是研究黑人妇女中与马有关的危险因素和其他危险因素与乳腺癌亚型之间关联的最全面和驱动力量的研究之一。此外，肿瘤组织的收集将提供直接的未来机会，将这些危险因素分析扩展到内在的分子亚型。这项研究的结果将填补有关与马有关的因素的当前知识的重要差距，这些因素会增加黑人妇女对侵略性乳腺癌的风险，并有助于描绘出较高（或低）对乳腺癌亚型的风险不佳的黑人妇女的预后较差，而预后较差，而预后会受益最大，并可能从筛查中受益最大，并可能提供新目标，以减少黑人乳腺癌的侵略性乳腺癌风险。这可能为开发针对种族和乳腺癌亚型的临床有用的乳腺癌预测模型铺平了道路。