A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood

研究成年过渡过程中心理压力的新人口规模方法

• 批准号: 10493385
• 负责人: William G. Axinn
• 金额: $ 19.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493385
• 关键词: Address; Adult; Age; Archives; Biological Markers; Brain; COVID-19; COVID-19 stress; Child; Chronic stress; Collection; Communities; Consumption; Contraceptive Usage; Courtship; DNA; Data; Demographic Transitions; Diagnostic; Documentation; Evaluation; Event; Failure; Family; Family Study; General Population; Hair; Health; Hour; Household; Human; Hydrocortisone; Individual; Intervention; Investigation; Laboratories; Link; Marriage; Measurement; Measures; Mental Health; Neighborhoods; Outcome; Outcome Measure; Parents; Participant; Patient Self-Report; Physiological; Population; Population Research; Population Study; Predisposition; Procedures; Process; Production; Protocols documentation; Psychological Stress; Randomized; Refusal to Participate; Reporting; Research; Research Personnel; Resources; Respondent; Risk; Risk Factors; Risk-Taking; Role; SARS-CoV-2 exposure; Saliva; Sampling; Science; Selection Bias; Self-Examination; Shapes; Stress; Surveys; Telephone; Testing; Time; Visit; aged; arm; base; child bearing; cognitive performance; cohort; cost; design; experience; experimental study; field study; improved; innovation; member; novel strategies; post-COVID-19; resilience; response; sample collection; substance use; success; therapy design; young adult

PROJECT SUMMARY Population-scale measurements of psychological stress during the transition to adulthood are generally con- strained to either self-reported measures or biomarkers that reflect only recent hours of brain response to stress. Recent breakthroughs in the use of hair to obtain stable measures of cortisol—a biomarker for the im- pact of stress on the human brain—has the potential to revolutionize this science. Hair-based cortisol provides a reliable measure of brain-experienced stress levels for the three months directly preceding collection of a hair sample. Laboratory processes for cortisol analysis of hair are now available at a scale that can be used for general population research. Like some other biomarkers, hair could be collected by study participants them- selves, greatly lowering the costs of adding such measurement to population-scale research. However, the field currently has no carefully studied protocol for large-scale hair collection, and no information about the se- lection biases likely to result from self-collection rather than professional-collection. We will overcome this obstacle by using a large, randomized experiment to assess options for integration of hair-based cortisol measurement into population-scale studies. This experiment, comparing self-collection of hair for cortisol to professional-collection, will be integrated into a long-term family panel study with existing predictors of stress and the transition to adulthood from neighborhoods, households, parents, and individual young adults. These measures will support comprehensive evaluation of the selection bias in self-collection of hair samples. We will randomly assign 1,448 respondents aged 18-21 to two arms of an experiment comparing self-collection of hair to professional-collection. Analyses will examine success collecting hair, the quality of the hair sample, and the participant’s self-evaluation of the process. We will link measures of these outcomes to thousands of existing measures of events over time in the individuals’ own lives, their parents’ lives, the lives of other household members, and the local community context. Analyses will feature exploration of all measures to identify any that are associated with refusal to participate, compliance with self-collection, quality of the hair samples, or self-reports of adverse responses to the hair-collection protocols. Results from these analyses will provide the means to establish the limitations of large-scale hair-based cortisol self-collection. We will design an optimal protocol for integrating hair-based cortisol collection into pop- ulation studies across settings and release that protocol to the public. We will also archive these innovative cortisol measures and collection procedures at ICPSR, allowing all researchers to launch innovative new anal- yses of psychological stress in the transition to adulthood. At the conclusion of this R21, our team will propose R01-scale research using this new protocol to link mental health before COVID-19 and stress during COVID- 19-era transitions to adulthood to trajectories of courtship, marriage, contraceptive use, and childbearing.

项目摘要 在过渡到成年期间，人口尺度的心理压力测量通常是 紧张地屈服于自我报告的措施或生物标志物，这些措施仅反映了最近的大脑反应数小时 压力。最近使用头发获得皮质醇的稳定测量的突破，这是IM的生物标志物 对人脑的压力契约是彻底改变这项科学的潜力。基于头发的皮质醇提供 在头发收集到的三个月中，三个月的脑经验应力水平的可靠度量 样本。现在可以使用用于皮质醇分析的实验室过程，以适用于 一般人口研究。像其他一些生物标志物一样，研究参与者可以收集头发 - 自我，很大程度上降低了将这种测量添加到人群规模研究中的成本。但是， Field目前尚未仔细研究大规模收集的协议，也没有有关Se-的信息 分区偏见可能是由于自我收集而不是专业收集而导致的。 我们将通过使用大型随机实验来评估集成选项来克服这一障碍 基于头发的皮质醇测量到人群尺度研究。这个实验，比较 皮质醇至专业收集的头发，将纳入一项长期家庭小组研究中 压力的预测因素以及从社区，家庭，父母和个人到成年的过渡 年轻人。这些措施将支持对选择偏见的全面评估 头发样品。我们将将18-21岁的受访者随机分配给实验的两个臂，以比较 头发自我收集到专业收集。分析将检查收集头发的成功， 头发样本，以及参与者对过程的自我评估。我们将将这些结果的措施链接到 随着个人的生活，父母的生活和生活，成千上万的现有事件衡量 其他家庭成员和当地社区的背景。分析将探索所有措施 要确定与拒绝参与的任何相关的人，请遵守自我收集，头发质量 样本或对毛收集方案的不良反应的自我报告。 这些分析的结果将为建立大规模头发的局限性提供手段 皮质醇自我收集。我们将设计一个最佳协议，用于将基于头发的皮质醇集成到POP- 跨环境的研究并将该协议发布给公众。我们还将归档这些创新的 ICPSR的皮质醇测量和收集程序，使所有研究人员都能发起创新的新肛门 在过渡到成年期间的心理压力。在此R21结束时，我们的团队将提出建议 R01规模的研究使用该新方案在COVID-19之前将心理健康联系起来，并在COVID期间进行压力 19-时代过渡到成年，向求爱，婚姻，避孕药使用和生育的轨迹轨迹。