Intergenerational Influences on Marriage, Contraception and Childbearing

婚姻、避孕和生育的代际影响

• 批准号: 10366002
• 负责人: William G. Axinn
• 金额: $ 62.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10366002
• 关键词: Address; Adult; Age; Archives; Behavior; Cellular Phone; Characteristics; Child; Child Mental Disorders; Child Welfare; Childhood; Clinical; Communities; Contraceptive Usage; Contraceptive methods; DNA; Data; Diagnostic; Disease; Divorce; Education; Elderly; Event; Family; Family Study; Fathers; General Population; Generations; Genetic; Genetic Research; Genetic study; Health; High Prevalence; Household; Income; Individual; Infrastructure; Internet; Interview; Investigation; Knowledge; Link; Living Arrangement; Marriage; Measurement; Measures; Mediating; Mental Health; Mental disorders; Modeling; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Outcome; Parents; Personal Satisfaction; Persons; Play; Population; Population Growth; Pregnancy; Process; Recording of previous events; Research; Research Design; Risk-Taking; Role; Saliva; Sampling; Severities; Sexually Transmitted Diseases; Shapes; Social Sciences; Structure; Surveys; Telephone Interviews; Time; Variant; Work; base; child bearing; community-level factor; design; early childhood; effective intervention; experience; innovation; intergenerational; parental influence; parental role; polygenic risk score; prospective; sex; sexual risk taking; substance use; tool; unintended pregnancy

PROJECT SUMMARY Family formation processes, including marriage, contraception, and childbearing, are among the most im- portant factors shaping the health and wellbeing of families and children. The substantial, long-term conse- quences of the parental family for children's family formation outcomes are among the most well-documented forces of change in the social sciences. However, a powerful factor has been overlooked—parental mental health. Not only are mental disorders highly prevalent the world over, but parental mental disorders are known to have powerful consequences for children, likely to shape their later-life family formation processes. We will address this important gap in research by integrating parental mental disorders into intergenerational models of family formation using a 24-year, prospective family panel study. To advance knowledge of these intergenera- tional processes using these new measures, we aim to: (1) Generate the first estimates of the role of parental mental disorders in shaping their children's subsequent marriage, contraception, and childbearing; (2) Use DNA-based polygenic risk scores from mothers, fathers, and their children to assess omitted genetic variable bias in these intergenerational models; and (3) Create and evaluate new prospective measures of sexual risk- taking and substance use mechanisms likely to link parental mental disorders to their children's marriage, con- traceptive use, and childbearing. The results will provide three significant advances. One is the first general population investigation of the intergenerational influence of parental mental disorders on children's marriage, contraception, and childbear- ing. A second is the first study of the genetic contribution to the intergenerational influences of parental mental disorders on family formation. To date nearly all population models of intergenerational influences on family formation are forced to conclude that unobserved genetic similarities may account for observed associations. We will introduce a new generation of intergenerational research—designs that integrate genetic propensities. The third is a significant advance in our understanding of the role played by children's premarital sex, sex with- out contraception, and substance use in linking parental factors to children's family formation, as these events could mediate this relationship. These steps will significantly advance our understanding of the intergenera- tional influences on the dynamics of marriage, contraception, and childbearing, all of which are crucial for health and wellbeing.

项目摘要 家庭形成过程，包括婚姻，避孕和生育，是最重要的 可移植因素塑造家庭和儿童的健康和福祉。大量的，长期的conse- 父母家庭对儿童家庭形成结果的查询是最有据可查的 社会科学的变化力量。但是，一个有力的因素被忽略了 - 育儿心理 健康。全世界的精神障碍不仅高度流行，而且父母精神障碍是已知的 为儿童带来强大的后果，可能会塑造其后期生活的家庭形成过程。我们将 通过将父母精神障碍纳入代际模型的研究中的这一重要差距 使用24年的前瞻性家庭小组研究进行家庭形成。促进这些属性的知识 使用这些新措施的过程过程，我们的目标是：（1）生成父母作用的第一个估计值 塑造孩子随后的婚姻，避孕和生育时的精神障碍； （2）使用 母亲，父亲及其子女评估遗漏的遗传变量的基于DNA的多基因风险评分 这些代际模型的偏见； （3）创建和评估性风险的新预期衡量 采取和主题使用可能将父母精神障碍与孩子的婚姻联系起来的机制， 痕量使用和生育。 结果将提供三个重大进展。一个是对 父母精神障碍对儿童婚姻，避孕和育儿的代际影响 - ing。第二个是对父母心理代际影响的遗传贡献的第一个研究 家庭形成的疾病。迄今为止，几乎所有代际影响对家庭的人口模型 形成被迫包括未观察到的遗传相似性可能是观察到的关联。 我们将介绍新一代的代际研究，即整合遗传规定的设计。 第三个是我们对儿童婚前性别，性别的作用的理解的重大进步 - 避孕和将父母因素与儿童家庭形成联系起来的避孕和物质使用，因为这些事件 可以调解这种关系。这些步骤将极大地提高我们对属间的理解 对婚姻，避孕和生育动力的影响，所有这些都对 健康和福祉。