Identification and impact of polymers on stem cell products in an automated biomanufacturing platform

自动化生物制造平台中聚合物对干细胞产品的识别和影响

• 批准号: 10089013
• 金额: $ 3.51万
• 依托单位: UNICORN BIOTECHNOLOGIES LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10089013
• 关键词: Identification; impact; polymers; stem; cell

The culture of mammalian cells underpins almost all life science R&D, is involved in the production of many therapeutics including recombinant proteins, antibodies, vaccines and underpins many next-generation therapeutics such as cell therapies for personalised medicine. One significant bottleneck preventing the widespread adoption of such technologies and additionally, their incorporation into clinical practice, is the infrastructure needed to manufacture such therapies in technoeconomically feasible ways. Unicorn Biotechnologies has made an end-to-end automated modular and scalable cell manufacturing system that automatically manufactures such cell products with minimal user input. This project will enhance the quality and reproducibility of our manufacturing system further by working with state-of-the-art specialist governmental technology institutions to perform detailed chemical and biological characterization of the materials used in our biomanufacturing platform.

哺乳动物细胞培养是几乎所有生命科学研发的基础，涉及许多治疗药物的生产，包括重组蛋白、抗体、疫苗，并支撑许多下一代治疗方法，例如个性化医疗的细胞疗法。阻碍此类技术广泛采用以及将其纳入临床实践的一个重要瓶颈是以技术经济上可行的方式制造此类疗法所需的基础设施。 Unicorn Biotechnologies 制造了一个端到端自动化模块化和可扩展的细胞制造系统，可以以最少的用户输入自动制造此类细胞产品。该项目将通过与最先进的专业政府技术机构合作，对我们的生物制造平台中使用的材料进行详细的化学和生物表征，进一步提高我们制造系统的质量和可重复性。