X-ray Scattering

X射线散射

• 批准号: 10460483
• 负责人: Lin Yang
• 金额: $ 49.48万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460483
• 关键词: Automation; Basic Science; Biological; Biological Sciences; Cells; Charge; Collaborations; Communities; Computer Simulation; Computer software; Data; Data Analyses; Data Collection; Data Files; Department of Energy; Educational workshop; Emergency Situation; Ensure; Equipment; Equipment Failure; Exclusion; Failure; Fluorescence; Funding; Goals; Image; Individual; Investigation; Libraries; Light; Liquid Chromatography; Maintenance; Measurement; Metadata; Monitor; National Institute of General Medical Sciences; Neutrons; Optics; Performance; Recovery; Research; Research Personnel; Research Support; Resources; Robot; Roentgen Rays; Sampling; Scanning; Schedule; Source; Speed; Structure; Synchrotrons; Techniques; Technology; Time; Training; United States National Institutes of Health; Work; base; beamline; computerized data processing; data standards; experience; flexibility; graphical user interface; improved; instrument; instrumentation; interest; machine vision; new technology; operation; programs; quality assurance; repaired; simulation; simulation software; software development; usability

Abstract – X-ray Scattering Technology Core The X-ray Scattering Technology Core will provide user access to solution scattering and microbeam diffraction measurements at the Life Science X-ray Scattering (LiX) beamline and will continue to improve instrumentation reliability and the user experience at the beamline. We aim to achieve these goals by working on multiple fronts. We will provide HDF5 data packaging and user interfaces for data collection, browsing, processing and analysis. We will implement a Sample Manager for tracking samples and data, and for scheduling measurements and define data processing data flow. We will also work on software utilities to facilitate measurement automation, performance optimization and failure recovery. These capabilities will enable us to offer remote access and mail-in data collection for solution scattering, and to achieve a higher level of automation and therefore throughput with microbeam mapping. In addition to standard data analysis packages for solution scattering, enhanced capabilities for data analysis will be realized by making available at the beamline computer simulations for structural analysis on flexible structures and working with the user community to expand the data analysis library for microbeam mapping. Capabilities for time-resolved solution scattering will be acquired through collaboration and externally-funded research and made available to the all users. We will familiarize the user community with these beamline capabilities through hands-on training classes and workshops on advanced topics. Routine quality-assurance checks will be performed to monitor instrument performance and to resolve issues before they impact beamline operations. Equipment pools shared with other beamlines under this proposal and within National Synchrotron Light Source II (NSLS-II) will provide spare components in case of emergency to allow time for repair and recovery. To maintain the competitiveness of the beamline, we propose to complete the LiX mutlilayer monochromator, to provide higher beam intensity at the sample and the flexibility of trading beam intensity for smaller beam size or better beam stability.

摘要 - X射线散射技术核心 X射线散射技术核心将为用户访问解决方案散射和Microbeam Life Science X射线散射（LIX）光束线的衍射测量值将继续 改进仪器的可靠性和梁线上的用户体验。我们旨在实现这些 通过在多个方面工作的目标。我们将为数据提供HDF5数据包装和用户界面 收集，浏览，处理和分析。我们将实施一个示例管理器来跟踪 示例和数据，以及调度测量并定义数据处理数据流。我们也会 在软件实用程序上工作以促进测量自动化，性能优化和失败 恢复。这些功能将使我们能够为解决方案提供远程访问和邮寄数据收集 散射，并实现更高水平的自动化，因此用微束进行吞吐量 映射。除了用于解决方案散射的标准数据分析软件包外，功能增强 为了进行数据分析，将通过在梁线计算机模拟中提供 关于灵活结构并与用户社区合作扩展数据的结构分析 用于微生映射的分析库。时间分辨溶液散射的功能将是 通过协作和外部资助的研究获得，并提供给所有用户。我们 通过动手培训课程将用户社区熟悉这些梁线功能 以及有关高级主题的讲习班。将执行常规质量保证检查以监视 仪器性能并解决问题，然后才能影响光束线操作。设备 在该提案下以及国家同步灯源内与其他光束线共享的池 II（NSLS-II）将在紧急情况下提供备用组件，以便时间进行维修和恢复时间。 为了保持光束线的竞争力，我们建议完成Lix Mutlilayer 单色器，以在样品处提供更高的光束强度和交易光束的灵活性 较小的光束尺寸或更好的光束稳定性的强度。