Lab Automation for a Genomics Shared Resources

基因组学共享资源的实验室自动化

• 批准号: 10735415
• 负责人: SCOTT A. NESS
• 金额: $ 6.8万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10735415
• 关键词: American Cancer Society; Automation; Award; Basic Science; Biological Assay; Cell Line; Cells; Clinical; Clinical Research; Communities; Complement; Complex; Comprehensive Cancer Center; Core Facility; DNA; DNA purification; Data; Development; Eligibility Determination; Epigenetic Process; Equipment; Fees; Financial Support; Formaldehyde; Funding; Gene Expression; Genomics; Genomics Shared Resource; Germ-Line Mutation; Goals; Grant; Hand; Health Sciences; Hereditary Disease; Institution; Investments; Laboratories; Libraries; Link; Malignant Neoplasms; Manuals; Modernization; Mutation; New Mexico; Nucleic Acids; Outsourcing; Paraffin Embedding; Patients; Procedures; Process; RNA; RNA purification; Reproducibility; Request for Applications; Research; Research Personnel; Research Project Grants; Robot; Running; Sampling; Services; Speed; Standardization; Techniques; Technology; Time; Tissues; Translational Research; United States National Institutes of Health; Universities; cancer cell; cell transformation; cell type; cost; cost effective; empowerment; equipment acquisition; experimental study; flexibility; improved; innovation; instrument; instrumentation; member; model organism; next generation sequencing; nucleic acid purification; operation; programs; tool; translational genomics; translational study; tumor

Project Summary/Abstract The goal of this application is to improve and streamline the operating processes and procedures in the Analytical and Translational Genomics (ATG) Shared Resource, a key core facility focused on next-generation sequencing and genomics technologies in the University of New Mexico Comprehensive Cancer Center (UNMCCC). We are requesting funds for nucleic acid extraction equipment. Specifically, a Qiagen EZ2 Connect automated nucleic acid purification robot. Adding this instrument to the ATG Shared Resource will modernize and automate the successful workflows that are already in place and will improve throughput, expand the menu of services and lead to reduced costs and faster turnaround for our users. The requested equipment will automate procedures that are now performed by hand by the ATG technical staff, allowing them to focus on more complex downstream activities, such as preparing various types of sequencing libraries. The requested equipment is not a scientific research instrument that acquires experimental data, but it will significantly enhance support operations and will benefit the user community and multiple research projects of many investigators. ATG is partially supported by UNMCCC, one of only three NCI-Designated Comprehensive Cancer Centers in an NIH Institutional Development Award (IDeA) Program-eligible state. ATG is widely used by laboratories at UNM. In the last 5 years ATG billed 73 UNM laboratories for nearly $1.75 million in user fees for genomics services. The requested equipment will complement and augment recent investments in new sequencing instruments, made with funds from UNMCCC and the UNM Health Sciences Center, and will greatly benefit a wide range of users, both UNMCCC members and non-members, who utilize the genomics services provided by ATG.

项目摘要/摘要 该应用程序的目的是改进和简化该应用程序的操作过程和过程 分析和转化基因组学（ATG）共享资源，这是一个关键核心设施，重点是下一代 新墨西哥大学综合癌症中心的测序和基因组技术 （UNMCCC）。我们要求用于核酸提取设备的资金。具体而言，Qiagen EZ2 连接自动核酸纯化机器人。将此工具添加到ATG共享资源将 现代化和自动化已经已经存在并将改善吞吐量的成功工作流程 扩展服务菜单，并为我们的用户提供降低的成本和更快的周转速度。请求 设备将自动化程序，这些程序现在由ATG技术人员手动执行，允许他们 专注于更复杂的下游活动，例如准备各种类型的测序库。这 请求的设备不是获取实验数据的科学研究工具，但它将 显着增强了支持操作，将使用户社区和多个研究项目受益 许多调查员。 ATG由UNMCCC部分支持，这是仅有的三个NCI指定的之一 NIH机构发展奖（IDEA）符合计划资格的国家中的全面癌症中心。 ATG被实验室广泛使用。在过去的5年中 基因组服务的175万美元用户费用。请求的设备将补充和增强 最近用UNMCCC和UNM Health的资金制造的新测序工具的投资 科学中心，将大大受益于UNMCCC成员和非会员的广泛用户， 谁利用ATG提供的基因组服务。