Biospecimens Accessioning and Processing Shared Resource

生物样本登记和处理共享资源

• 批准号: 10113588
• 负责人: Mine Cicek
• 金额: $ 13.19万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-25 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10113588
• 关键词: Accreditation; Aliquot; All of Us Research Program; American; American Cancer Society; American College of Radiology Imaging Network; Arizona; Automation; Award; Basic Science; Biological; Blood; Cell Separation; Clinic; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Collection; Communities; Comprehensive Cancer Center; Consent; Cryopreservation; DNA; Data; Eastern Cooperative Oncology Group; Florida; Freezing; Future; Genomics; Goals; Grant; Individual; Infrastructure; Laboratories; Link; Malignant Neoplasms; Mayo Clinic Cancer Center; Medical Records; Minnesota; Mission; Nucleic Acids; Paper; Participant; Pathologist; Patient Self-Report; Peripheral Blood Mononuclear Cell; Population Sciences; Precision Medicine Initiative; Process; Protocols documentation; Publishing; RNA; Research; Research Personnel; Research Support; Resource Sharing; Resources; Risk Factors; Robotics; Role; Route; Sampling; Services; Ships; Site; Specialized Program of Research Excellence; Specimen; Specimen Handling; Translational Research; Translations; United States National Institutes of Health; Work; anticancer research; biobank; clinical practice; cohort; college; data access; epigenomics; fecal microbiome; individualized medicine; member; metabolomics; microbiome analysis; programs; research study; transcriptomics; volunteer

BIOSPECIMENS ACCESSIONING AND PROCESSING SHARED RESOURCE PROJECT SUMMARY The Mayo Clinic research enterprise includes several well-established, NIH-supported research programs and centers, including the NCI-designated comprehensive Mayo Clinic Cancer Center (MCCC) and the Mayo Clinic Center for Individualized Medicine (CIM) whose goal is to move advances in genomics, epigenomics, transcriptomics, and metabolomics into the clinic as rapidly as possible. The Biorepository Program, 1 of the 7 infrastructure programs overseen by CIM, is enterprise-wide, with all activities represented at Mayo Clinic Rochester, Mayo Clinic Florida, and Mayo Clinic Arizona. The mission of the Biorepository Program is to provide world-class biorepositories and state-of-the-art biospecimen processing and storage with a focus on quality and service. The Biorepository Program's Biospecimens Accessioning and Processing (BAP) laboratory provides pre-analytical processing and storage of any type of biospecimen to support the eventual translation of scientific discoveries into clinical practice. In addition to its role as an MCCC Shared Resource, BAP provides extensive support to a number of cancer-related Specialized Programs of Research Excellence (SPOREs); clinical trial groups, such Alliance and Academic and Community Cancer Research United (ACCRU); multisite/consortium groups; and the American Cancer Society. BAP's electronic biospecimen accessioning and tracking, combined with a broad range of specimen processing services, have created a very powerful, synergistic resource that is invaluable for supporting the Basic Science, Clinical and Translational Research and Population Sciences Programs of the MCCC. BAP is also a great biospecimen resource for MCCC members. There are 2 large cohorts that the BAP lab stores in the biorepository: 1) The Mayo Clinic Biobank is an institutional resource that contains biological specimens from 50,000 volunteers from our clinics who also provided self-reported risk-factor data, access to the clinical data in their medical records, and consent to participate in unspecified research studies. Today, over 1.25 million aliquots have been prepared and stored in a robotic freezer for future use. Data and specimens have been requested by close to 90 Mayo Clinic investigators from all 3 sites for more than 200 approved projects. On average, two-thirds of the PIs requesting specimens are MCCC members; 2) The All of Us Research Program Biobank is an NIH Precision Medicine Initiative; in 2016, BAP was tapped to be the central biobank for processing and storing biospecimens from 1 million participants. The 34 million specimens, together with their corresponding data, will be another good resource for the research of MCCC members. This award, together with institutional support, has allowed BAP to expand in capacity, capability, automation, and space, which will be a great benefit to MCCC members.

生物测量加入和处理共享资源项目摘要 梅奥诊所研究企业包括几个公认的，由NIH支持的研究计划， 中心，包括NCI指定的综合梅奥诊所癌症中心（MCCC）和梅奥诊所 个性化医学中心（CIM），其目标是推动基因组学，表观基因组学的进步 转录组学和代谢组学尽快进入诊所。 Biorepository计划，第7个中的1个 由CIM监督的基础设施计划在企业范围内，所有活动均在Mayo Clinic中代表 罗切斯特，佛罗里达州梅奥诊所和亚利桑那州梅奥诊所。 BioreSository计划的任务是 提供世界一流的生物疗法和最先进的生物循环处理和存储，重点 质量和服务。 Biorepository计划的生物测量戒指（BAP）实验室 提供任何类型的生物测量的分析前处理和存储，以支持最终的翻译 临床实践中的科学发现。除了作为MCCC共享资源的角色外，BAP 为许多与癌症相关的专业研究提供了广泛的支持 （孢子）;临床试验小组，这样的联盟以及学术和社区癌症研究联合 （accru）;多站点/财团组；和美国癌症协会。 BAP的电子生物测量 加入和跟踪，结合广泛的标本处理服务，创造了一个非常 强大，协同的资源对于支持基础科学，临床和翻译是无价的 MCCC的研究与人口科学计划。 BAP也是一个很棒的生物测量资源 MCCC成员。 BAP实验室在生物座位上存储了2个大型队列：1）蛋黄酱诊所 生物库是一种机构资源，其中包含来自我们诊所的50,000名志愿者的生物标本 他还提供了自我报告的风险因素数据，访问其病历中的临床数据以及 同意参加未指定的研究。如今，已经准备了超过125万的等分试样 并存储在机器人冰箱中供将来使用。数据和标本已接近90 Mayo要求 来自200多个批准项目的所有3个站点的诊所调查人员。平均而言，三分之二的PI 要求标本是MCCC成员； 2）我们所有的研究计划生物库都是NIH的精度 医学倡议；在2016年，BAP被击败为处理和存储的中央生物库 来自100万参与者的生物测量。 3400万标本以及它们的相应数据将 成为MCCC成员研究的另一个好资源。该奖项以及机构支持， 允许BAP扩大能力，能力，自动化和空间，这将是一个很大的好处 MCCC成员。