Precision Medicine Initiative Cohort Program Biobank

精准医学计划队列计划生物样本库

• 批准号: 9543627
• 负责人: Mine Cicek
• 金额: $ 2621.8万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9543627
• 关键词: Address; Advanced Malignant Neoplasm; Automation; Back; Biological; Blood; Businesses; Characteristics; Client; Clinic; Clinical Research; Clinical Services; Collection; Committee Members; Complex; Data; Disaster Planning; Disease; Elements; Enrollment; Ensure; Environment; Feces; Fee-for-Service Plans; Genome; Genomics; Goals; Health; Healthcare Systems; Hospitals; Human Volunteers; Individual; Information Management; Institution; Intention; International; Label; Laboratories; Laboratory Research; Life Style; Link; Logistics; Management Information Systems; Medical; Medical Records; PMI cohort; Participant; Patient Care; Patients; Population; Precision Medicine Initiative; Prevention strategy; Process; Protocols documentation; Public Health; Questionnaires; Recovery; Recruitment Activity; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Retrieval; Robotics; Route; Saliva; Sampling; Scientific Advances and Accomplishments; Secure; Services; Ships; Site; Specimen; Specimen Handling; System; Technology; Tissues; Transportation; United States; Urine; Work; arm; biobank; cohort; cost; cost effective; epigenomics; genetic disorder diagnosis; improved; individualized medicine; metabolomics; microbiome; multidisciplinary; precision medicine; programs; quality assurance; response; scale up; square foot; success; transcriptomics; treatment strategy; virtual; volunteer

PROJECT SUMMARY / ABSTRACT In his State of the Union address on January 20, 2015, President Obama announced his intention to launch the Precision Medicine Initiative (PMI). The goal of the PMI Cohort Program is to enroll one million volunteers into a national cohort that broadly reflects the diversity of the U.S. population and accelerate progress toward a new era of precision medicine on a larger scale than previously possible. The objective of this proposal is to utilize the full resources available through the Mayo Clinic Biorepositories Program and Mayo Medical Laboratories to efficiently and cost effectively support the activities of the PMI Cohort Program with respect to the Biobank, namely, biospecimen collection, kit assembly, biospecimen accessioning, tracking, processing, quality assurance, storage, and distribution. Mayo Medical Laboratories, the third largest reference laboratory in the United States, will enable efficient specimen transportation, routing, and information management between PMI collection sites and the Mayo Clinic Biobank. The aims of this proposal are to: (1) To provide collection kits and leverage existing sample shipment logistics to ensure specimens arrive at Mayo Clinic Rochester in the most expedient, efficient, and safe manner possible, in accordance with all federal and state regulations; (2) Scale up existing state-of-the-art laboratory automation and robotics to process, label, and store biospecimens, using established protocols compliant with laboratory best practices for all steps of specimen handling; (3) Use our high-quality, robust, and secure research laboratory information management system (RLIMS) for detailed tracking of sample receipt, processing, storage, retrieval, and distribution, while protecting participant confidentiality; (4) Apply our comprehensive Quality Management Program to ensure all work carried out is of the highest quality, and safeguard the collection with robust back-up systems and plans for disaster recovery; and (5) Work closely with the Coordinating Center, Collection Sites, and all other PMI Cohort Program Steering Committee Members to share biobanking expertise, infrastructure, and data to further the goals of the PMI. Overall, the Mayo Clinic Biorepositories Program laboratories combined with Mayo Medical Laboratories provide an unparalleled ability to collect, accession, process, distribute, store, and manage virtually any type of biospecimen on behalf of the Precision Medicine Initiative Cohort Program.

项目摘要 /摘要 奥巴马总统在2015年1月20日的国情公司讲话中宣布 启动Precision Medicine Initiative（PMI）。 PMI队列计划的目标是注册一百万 志愿者进入一个国家队列，该队列广泛反映了美国人口的多样性并加速 朝着比以前可能更大的范围更大的精密医学新时代的进步。目的 该建议是利用通过Mayo Clinic BioreSosories计划和 梅奥医疗实验室有效和成本有效地支持PMI队列计划的活动 关于生物库，即生物循环收集，套件组件，生物镜登录，跟踪， 处理，质量保证，存储和分配。梅奥医疗实验室，第三大参考 美国的实验室将实现有效的标本运输，路线和信息 PMI收集站点与梅奥诊所生物库之间的管理。该提议的目的是：（1） 提供收集套件并利用现有的样品运输物流以确保标本到达Mayo 根据所有联邦和 国家法规； （2）扩展现有的最新实验室自动化和机器人技术来处理标签， 并存储生物测量，使用既定协议符合实验室的最佳实践，以实现所有步骤 标本处理； （3）使用我们的高质量，健壮且安全的研究实验室信息管理 系统（RLIM），用于详细跟踪样品收据，处理，存储，检索和分销，而 保护参与者的机密性； （4）应用我们的全面质量管理计划来确保所有人 进行的工作是最高质量的，并通过强大的备份系统和计划来保护该系列 用于灾难恢复； （5）与协调中心，收集站点和所有其他PMI紧密合作 队列计划指导委员会成员共享生物库的专业知识，基础设施和数据 进一步的PMI目标。总体而言，梅奥诊所生物库计划实验室结合 Mayo医疗实验室提供了无与伦比的收集，加入，过程，分发，存储和 代表Precision Medicine Initiative队列计划管理几乎任何类型的生物循环。