CSHL 2022 Protein Homeostasis in Health and Disease Conference

CSHL 2022健康与疾病中的蛋白质稳态会议

基本信息

批准号：
10452207
负责人：
DAVID J. STEWART
金额：
$ 3.19万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10452207
关键词：
3-Dimensional Address Affect Age Aging Alzheimer&apos s Disease Amino Acids Amyloidosis Animal Model Area Attention Autophagocytosis Basic Science Binding Biochemical Biogenesis Biology Biology of Aging Biomedical Research Biophysics Businesses Cell Compartmentation Cell physiology Cells Cellular Stress Client Communicable Diseases Complement Complex Data Development Diabetes Mellitus Discipline Disease Ensure Environment Equilibrium Explosion Faculty Failure Feedback Financial Support Fire - disasters Fostering Funding Future General Population Goals Health Heart Heart Diseases Heat shock proteins Heat-Shock Response Homeostasis Huntington Disease In Vitro Industry International Knowledge Laboratories Malignant Neoplasms Measures Medicine Metabolic Diseases Metabolism Methods Molecular Molecular Chaperones Nerve Degeneration Neurodegenerative Disorders Oral Organism Parkinson Disease Participant Pathway interactions Phase Transition Physiology Polymers Postdoctoral Fellow Prion Diseases Process Protein Biosynthesis Protein Conformation Proteins Publishing Quality Control Questionnaires Recording of previous events Research Institute Research Personnel Ribosomes Role Schedule Science Scientist Signal Transduction Slide Stress Therapeutic Thinking Time Toxic effect Translating Triage Woman Work age effect age related arm biological adaptation to stress career cell type disorder risk graduate student healthy aging hormonal signals in vivo insight interest lectures macromolecular assembly meetings multicatalytic endopeptidase complex novel polypeptide posters protein aggregation protein degradation protein folding protein function protein misfolding proteostasis repaired response stress granule success symposium tumor metabolism virtual

项目摘要

Cold Spring Harbor Laboratory Conference on Protein Homeostasis in Health and Disease April 26 - 30, 2022 ABSTRACT This proposal is a request for financial support for a meeting on PROTEIN HOMEOSTASIS IN HEALTH AND DISEASE to be held at Cold Spring Harbor Laboratory from April 26 - 30, 2022. This meeting is the premier international forum for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the relevance of this process to healthy aging and risk for diseases of neurodegeneration, cancer, and metabolism guarantees an excitement and urgency of this meeting. Because of the recent developments on stress signaling in aging and disease, we will open the meeting with this new session followed the next day with a session on protein aggregation in aging and neurodegenerative diseases and then closing the meeting with a session on correcting proteostasis in aging and disease. Additional sessions will address the relationship between protein synthesis, folding, translocation and degradation by discussing the molecular mechanisms of chaperone function, degradative mechanisms and on spatial quality control and organellar proteostasis. The meeting will also introduce another new session on stress granules and phase transitions that has brought many new concepts on stress physiology, regulatory biology and novel forms of macromolecular interaction. These fundamental questions are at the heart of biology of proteostasis that will be complemented by the sessions on aging and proteostasis failure in diseases of protein misfolding including Alzheimer's disease, ALS, Parkinson's disease and Huntington's disease. The themes of aging, proteostasis failure, and diseases of protein misfolding are well integrated throughout the meeting, and emerging principles on protein client interactions and alternate protein conformations will be predominantly displayed. The diverse protein quality control strategies used by compartments of the cell to ensure the integrity of the secretory and organellar pathways during times of protein folding stress will be represented by emerging topics on spatial quality control within a cell. The field of heat shock proteins and molecular chaperones has grown exponentially and draws interest not only from traditional scientific disciplines in the basic sciences but also from diverse areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will have eight lecture sessions, two poster sessions, two rapid-fire presentation sessions, and a panel discussion on scientific publishing. The sessions include: 1) Integrative Stress Signaling in Biology, Aging and Disease; 2) Protein Aggregation in Aging and Neurodegenerative Diseases; 3) Molecular Mechanisms of Chaperones; 4) Mechanisms of Autophagy and Proteasome Degradation; 5) Intrinsically Disorder Proteins, Phase Transitions and Stress Granules; 6) Folding at the Ribosome and Triage Mechanisms; 7) Organellar Proteostasis and Spatial Quality Control in Aging and Disease; and 8) Restoring Proteostasis in Aging and Disease. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. Generally, two speakers will be pre-invited per session with the remainder to be selected from submitted abstracts, thus ~60- 65% of speakers will be from submitted abstracts to ensure balance of junior investigators, women and all forms of diversity. As well, we will have two rapid fire sessions, each with ten-2 min. talks to increase the visibility from the poster sessions. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, and to encourage diverse participation that recognizes new investigators.

冷泉港实验室会议健康和疾病中的蛋白质稳态 2022年4月26日至30日抽象的该提案是为蛋白质稳态会议提供财政支持的请求健康与疾病将于 2022 年 4 月 26 日至 30 日在冷泉港实验室举行。这次会议是展示该领域新成果的首要国际论坛，几乎该领域每个主要实验室的代表都出席了会议。的爆炸关于蛋白质折叠状态如何在体内获得和维持的新信息以及这一过程与健康老龄化和神经退行性疾病、癌症、新陈代谢保证了这次会议的兴奋性和紧迫性。因为最近衰老和疾病中压力信号的发展，我们将用这个新的第二天的会议是关于衰老和蛋白质聚集的会议神经退行性疾病，然后以纠正问题的会议结束会议衰老和疾病中的蛋白质稳态。其他会议将讨论之间的关系通过讨论分子结构来了解蛋白质的合成、折叠、易位和降解伴侣功能机制、降解机制以及空间质量控制和细胞器蛋白质稳态。会议还将推出另一场关于压力的新会议颗粒和相变带来了许多关于应激生理学的新概念，调节生物学和大分子相互作用的新形式。这些基本问题是蛋白质稳态生物学的核心，衰老会议将对其进行补充以及蛋白质错误折叠疾病中的蛋白质稳态失败，包括阿尔茨海默病、ALS、帕金森病和亨廷顿舞蹈病。衰老、蛋白质稳态失败等主题蛋白质错误折叠疾病在整个会议中得到了很好的整合，并且正在出现蛋白质客户相互作用和替代蛋白质构象的原则将是主要显示。隔室使用的多种蛋白质质量控制策略细胞的完整性，以确保分泌和细胞器途径的完整性蛋白质折叠应力将以空间质量控制的新兴主题为代表细胞。热休克蛋白和分子伴侣领域呈指数级增长，不仅引起了基础科学中传统科学学科的兴趣，而且引起了人们的兴趣生物医学研究的各个领域，包括神经退行性疾病、传染病、癌症、心脏病和衰老。会议将设有八场报告会、两场墙报会议、两次快速演示会议以及关于科学出版的小组讨论。会议包括： 1) 生物学、衰老和疾病中的综合压力信号； 2) 蛋白质衰老和神经退行性疾病的聚集； 3) 分子机制监护人； 4）自噬和蛋白酶体降解机制； 5）本质上无序蛋白质、相变和应力颗粒； 6) 核糖体折叠和分类机制； 7) 衰老过程中的细胞器蛋白质稳态和空间质量控制疾病; 8) 恢复衰老和疾病中的蛋白质稳态。每场会议将由八个九场口头演讲，并将由一位受邀演讲者主持。一般情况下，两个扬声器每场会议都被预先邀请，其余的则从提交的摘要中选择，因此~60- 65% 的演讲者将来自提交的摘要，以确保初级研究人员的平衡，妇女和各种形式的多样性。此外，我们还将进行两次快速射击会议，每次都有 10-2 分钟。演讲以提高海报会议的知名度。这种谈判的平衡使得会议以顶尖科学家的演讲为特色，对令人兴奋的新事物做出反应发展，并鼓励认可新研究人员的多元化参与。