Advanced Training at the Interface of Engineering and Oral-Craniofacial Sciences

工程与口腔颅面科学交叉领域的高级培训

• 批准号: 10441630
• 负责人: Hyun Koo
• 金额: $ 9.82万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441630
• 关键词: Address; Adopted; Applied Research; Artificial Intelligence; Awareness; Biology; Clinical; Clinical Research; Committee Members; Complex; Computational Science; Dental; Dental Schools; Dental caries; Dentistry; Dentists; Development; Disease; Educational workshop; Elements; Engineering; Enrollment; Environment; Faculty; Family; Funding; Healthcare; Immunity; Industry; Interdisciplinary Study; Journals; K-Series Research Career Programs; Medical; Medicine; Mentors; Mentorship; Minority; Mouth Diseases; Nanotechnology; National Institute of Dental and Craniofacial Research; Oral; Oral health; Patients; Pennsylvania; Periodontal Diseases; Persons; Population; Poverty; Records; Regulatory Affairs; Reproducibility; Research; Research Project Grants; Research Training; Resources; Robotics; Schools; Science; Scientist; Training; Training Programs; Translational Research; Universities; Vision; Writing; career; career development; craniofacial; craniofacial complex; experience; innovation; malignant mouth neoplasm; materials science; microbiome; multidisciplinary; novel; novel strategies; oral biofilm; personalized medicine; programs; symposium; tissue regeneration

Contact PD/PI: KOO, HYUN Oral diseases and disorders in the craniofacial complex disproportionally and devastatingly afflict susceptible populations, particularly impoverished families and medically or physically compromised persons. Novel engineering approaches, properly leveraged, can yield new paradigms to reveal disease mechanism, new strategies for disease mitigation, and new approaches for affordable/personalized therapies for dental caries, periodontal diseases, and oral cancer. To achieve this vision, academic research bound dentist-scientists must be adept in engineering concepts and engineers must be educated in oral and craniofacial sciences and needs; all must be aware of the complex clinical and regulatory landscapes. To address this urgent need, we propose a multidisciplinary training program in Penn’s School of Dental Medicine (PDM) and School of Engineering & Applied Sciences (SEAS) focused on training dentist-scientists and engineers for academic careers dedicated to research in precision oral health and healthcare innovation. Postdoctoral trainees will adopt cutting-edge approaches at the forefront of engineering and computational sciences to advance the fields of oral biofilm microbiome, host immunity and tissue regeneration, drawing on approaches including artificial intelligence, robotics, nanotechnology, and materials sciences, aware of developmental hurdles and requirements to safely bring new approaches to patients. Trainees will engage in interactive and tailored academic experiences with intensive mentored research via co-mentoring (one advisor from each school), and interaction with a career mentoring committee (CMC) that includes at least one dental clinician. Co-mentors and CMC members will be drawn from the Program Faculty of 26 faculty in PDM and SEAS with significant records of mentorship of multidisciplinary and translational research. Training will include: (1) engineering fundamentals for dental trainees and oral & craniofacial biology principles for engineering trainees, tailored to match their research project and academic needs, (2) clinical research and regulatory affairs, (3) principles of scientific rigor and reproducibility, (4) scientific writing and (5) workshops on professional and career development. Trainees will engage in academic and industry interactions, journal club, give symposia presentations, and participate in AADR/IADR activities. Training will culminate in F/K award applications focused on advancing oral health at the dental-engineering interface. The applicant pool at the University of Pennsylvania is exceptionally strong and diverse, and we anticipate being able to attract outstanding candidates. Furthermore, via partnerships with ADA, AADR/IADR and minority-serving dental schools, we will diversify our candidate pool. We plan to enroll 4 trainees per year. Importantly, this effort will be an element of a newly formed inter-school center between PDM and SEAS with shared funding. The proposed program, unique to Penn, leverages a superb research and training environment within a compact campus where resources for both schools are united through Penn’s new Center for Innovation and Precision Dentistry. Project Summary/Abstract Page 6 Contact PD/PI: KOO, HYUN Advances in engineering approaches offer previously unimagined opportunities to advance the NIDCR 2030 vision of precision oral health for all. To harness this opportunity, a critical mass of cross-trained dentists and engineers engaged in oral and craniofacial research are urgently needed. We will develop this workforce.

联系PD/PI：Koo，Hyun 颅面复合物中的口腔疾病和疾病不成比例和破坏性地受伤 人口，特别是贫穷的家庭，医学或身体上受到损害的人。小说 适当利用的工程方法可以产生新的范式以揭示疾病机制，新的 缓解疾病的策略，以及针对牙科的负担得起/个性化疗法的新方法， 牙周疾病和口腔癌。为了实现这一愿景，学术研究约束牙医科学家必须 熟练的工程概念和工程师必须接受口头和颅面科学的教育， 需求；所有人都必须意识到复杂的临床和法规景观。为了满足这种迫切的需求，我们 提案在宾夕法尼亚州牙科医学学校（PDM）和学校的多学科培训计划和 工程与应用科学（SEA）着重于培训牙医科学家和工程师 致力于精确口腔健康和医疗创新研究的学术职业。博士后 学员将采用工程和计算科学的最前沿的尖端方法 推进口服生物膜微生物组，宿主免疫学和组织再生的领域，借鉴方法 包括人工智能，机器人技术，纳米技术和材料科学，了解发展 安全地为患者带来新方法的障碍和要求。学员将参与互动和 量身定制的学术经验，通过辅助人员进行密集的指导研究（每个顾问 学校），以及与职业心理委员会（CMC）的互动，其中至少包括一个牙科临床。 将从PDM和SEAS的26位教职员工中汲取联盟和CMC成员 多学科和翻译研究心态的重要记录。培训将包括：（1） 牙科学员的工程基础知识以及工程学员的口腔和颅面生物学原则， 量身定制以符合其研究项目和学术需求，（2）临床研究和监管事务，（3） 科学严谨性和可重复性的原则，（4）科学写作以及（5）专业和专业的讲习班 职业发展。学员将参与学术和行业互动，期刊俱乐部，提供研讨会 演讲，并参加AADR/IADR活动。培训将在F/K奖励申请中达到高潮 专注于在牙科工程界面上提高口腔健康。大学的申请人池 宾夕法尼亚州异常强大和潜水员，我们预计能够吸引杰出的 候选人。此外，通过与ADA，AADR/IADR和少数民族服务学校的合作伙伴关系，我们将 多样化我们的候选人池。我们计划每年注册4名学员。重要的是，这项工作将是 PDM和SEAS之间的新成立的学校中心，并提供共享资金。提议的计划， 宾夕法尼亚州独有的地方，在一个紧凑型校园内利用一流的研究和培训环境 两所学校的资源都是通过宾夕法尼亚州新的创新与精确牙科中心团结在一起的。 项目摘要/摘要页面6 联系PD/PI：Koo，Hyun 工程方法的进步提供了以前无法想象的机会来推进NIDCR 2030 所有人的精确口腔健康的愿景。为了利用这一机会，大量的交叉训练牙医和 迫切需要进行口腔和颅面研究的工程师。我们将发展这个劳动力。