The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

俄勒冈州立大学临床和转化科学中心：推进当今的发现以改善健康

基本信息

批准号：
10705933
负责人：
CYNTHIA A GERHARDT
金额：
$ 562.3万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-22 至 2030-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705933
关键词：
Address Adopted Appalachian Region Applied Research COVID-19 Clinical Clinical Research Clinical Sciences Clinical and Translational Science Awards Collaborations Communities Data Data Science Data Set Decision Making Democracy Development Discipline Disparity Dissemination and Implementation Education Effectiveness Ensure Environment Equity Faculty Foundations Funding Grant Growth Health Healthcare Human Individual Industry Infant Infrastructure Institution Investments Knowledge Leadership Left Life Cycle Stages Maternal Mortality Medical center Methods Ohio Outcomes Research Patients Pediatric Hospitals Population Process Public Health Racial injustice Reach, Effectiveness, Adoption, Implementation, and Maintenance Research Research Design Research Personnel Resource Informatics Resources Rural Science System Systems Integration Thinking Training Training Support Training and Education Translational Research Universities Validation Vision Voice Work career development clinical center clinical translation clinically relevant college community engaged research complex data computing resources cost data access demographics health care delivery health disparity health equity implementation science improved innovation lens member multi-site trial novel strategies opioid epidemic response skills social social health determinants tool translational pipeline

项目摘要

ABTRACT The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) was formed in 2007, with the vision to advance today’s discoveries to improve health for all. We employed a comprehensive approach to address the full spectrum of T1-T4 science via the education and career development of a highly trained workforce integrated with a robust system of CTR resources. We provided leadership in the CTSA Consortium through sharing of tools and methods to advance CTR; adopted innovations from other hubs; and fully engaged in CTSA Consortium activities (e.g., multisite trials). We also supported community engaged research addressing the most pressing health issues in our communities (e.g., opioid crisis, COVID-19). Yet, work remains. Thus, we build upon unique strengths at OSU/NCH and in Ohio’s communities. We have leveraged our strategic investment in data sciences, a robust environment of resources, and a vibrant CTR community to address CTS gaps and barriers. We will now address five CTS roadblocks to improve the quality, efficiency, and rigor of CTR: (1) need for improved efficiencies and effectiveness to advance CTR and ensure results are disseminated and implemented into healthcare; 2) education and training innovations do not reach the full CTR workforce, resulting in a declining and inadequately diverse CTS workforce, lacking the knowledge and skills to advance CTR; 3) limited authentic participation by diverse stakeholders across the research life cycle; 4) growth of complex datasets necessitates integration of clinical, environmental, and research data, with need for democratization of data accessibility to advance data equity; and 5) racial injustice, SDoH, the CTR teams we form, and interpretation of our results impact health disparities. Applying a health equity and DEIA framework to every activity, we will pursue five aims: Aim 1: Develop innovations in methods, approaches, and tools to address pressing roadblocks facing CTR. Aim 2: Support training and career development of the full CTS workforce. Aim 3: Engage voices from across academic and scientific disciplines, patients, communities, and industry to conduct CTR and CTS across the full lifecycle of the scientific process. Aim 4: Deploy an accessible, responsive, and integrated system of research resources. Aim 5: Democratize informatics resources by lowering the cost of entry for data access and computing resources. With a commitment to metric-driven decision-making, we will evaluate the impact of the CCTS by applying the RE- AIM framework to inform strategic pivots over the next 7 years. This proposal reaffirms our commitment to advance CTS and expands our engagement with stakeholders to increase rigorous, impactful, and relevant CTR. We will develop, share, and adopt innovations through focused CTS to enhance CTR for the communities we serve and those we engage. These resources, skilled workforce, and institutional strengths provide an agile foundation to facilitate rapid responses to emerging public health issues, and will ensure an equity lens is applied to all CTR so no one is left behind from the advances of CTR to improve human health.

添加俄亥俄州立大学（OSU）临床与转化科学中心（CCTS）于2007年成立愿意提高当今发现以改善所有人的健康。我们采用全面的通过高度的教育和职业发展来解决T1-T4科学的全部范围的方法经过培训的劳动力与强大的CTR资源系统集成在一起。我们在CTSA中提供了领导通过共享工具和方法来推进CTR的财团；采用其他枢纽的创新；和完全从事CTSA联盟活动（例如，多站点试验）。我们还支持社区参与研究解决社区中最紧迫的健康问题的研究（例如，阿片类药物危机，Covid-19）。然而，工作仍然存在。这是我们在OSU/NCH和俄亥俄州社区的独特优势的基础。我们有利用我们在数据科学，强大的资源环境和充满活力的CTR上利用我们的战略投资解决CTS差距和障碍的社区。现在，我们将向五个CTS障碍介绍以改进 CTR的质量，效率和严格：（1）需要提高效率和有效性以提高CTR和CTR 确保结果被传播并实施到医疗保健中； 2）教育和培训创新没有到达全部CTR劳动力，导致CTS劳动力的下降和不足的劳动力缺乏促进CTR的知识和技能； 3）各种利益相关者的真实参与有限研究生命周期； 4）复杂数据集的增长必要的临床，环境和环境的整合研究数据，需要民主化数据可访问性以提高数据权益； 5）种族伤害， SDOH，我们组成的CTR团队，对结果的解释会影响健康差异。应用健康对每项活动的公平和DEIA框架，我们将追求五个目标：目标1：发展创新解决CTR面向的压障碍的方法，方法和工具。目标2：支持培训和全CTS劳动力的职业发展。目标3：跨学术和科学的声音学科，患者，社区和行业在科学的整个生命周期内进行CTR和CTS 过程。目标4：部署可访问，响应且集成的研究资源系统。目标5：通过降低数据访问和计算资源的进入成本来使信息资源民主化。和我们对以公制驱动的决策做出的承诺，我们将通过应用重新来评估CCT的影响目标框架在未来7年内为战略枢纽提供信息。该提案重申了我们对提高CTS并扩大我们与利益相关者的参与，以增加严格，有影响力和相关性 CTR。我们将通过重点CTS开发，共享和采用创新，以增强社区的CTR 我们服务和我们参与的人。这些资源，熟练的劳动力和机构优势提供了敏捷促进对新兴公共卫生问题的快速回应的基础，并将确保股权镜头是适用于所有CTR，因此CTR的进步没有人抛弃以改善人类健康。