The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

俄勒冈州立大学临床和转化科学中心：推进当今的发现以改善健康

基本信息

批准号：
10705933
负责人：
CYNTHIA A GERHARDT
金额：
$ 562.3万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-22 至 2030-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705933
关键词：
Address Adopted Appalachian Region Applied Research COVID-19 Clinical Clinical Research Clinical Sciences Clinical and Translational Science Awards Collaborations Communities Data Data Science Data Set Decision Making Democracy Development Discipline Disparity Dissemination and Implementation Education Effectiveness Ensure Environment Equity Faculty Foundations Funding Grant Growth Health Healthcare Human Individual Industry Infant Infrastructure Institution Investments Knowledge Leadership Left Life Cycle Stages Maternal Mortality Medical center Methods Ohio Outcomes Research Patients Pediatric Hospitals Population Process Public Health Racial injustice Reach, Effectiveness, Adoption, Implementation, and Maintenance Research Research Design Research Personnel Resource Informatics Resources Rural Science System Systems Integration Thinking Training Training Support Training and Education Translational Research Universities Validation Vision Voice Work career development clinical center clinical translation clinically relevant college community engaged research complex data computing resources cost data access demographics health care delivery health disparity health equity implementation science improved innovation lens member multi-site trial novel strategies opioid epidemic response skills social social health determinants tool translational pipeline

项目摘要

ABTRACT The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) was formed in 2007, with the vision to advance today’s discoveries to improve health for all. We employed a comprehensive approach to address the full spectrum of T1-T4 science via the education and career development of a highly trained workforce integrated with a robust system of CTR resources. We provided leadership in the CTSA Consortium through sharing of tools and methods to advance CTR; adopted innovations from other hubs; and fully engaged in CTSA Consortium activities (e.g., multisite trials). We also supported community engaged research addressing the most pressing health issues in our communities (e.g., opioid crisis, COVID-19). Yet, work remains. Thus, we build upon unique strengths at OSU/NCH and in Ohio’s communities. We have leveraged our strategic investment in data sciences, a robust environment of resources, and a vibrant CTR community to address CTS gaps and barriers. We will now address five CTS roadblocks to improve the quality, efficiency, and rigor of CTR: (1) need for improved efficiencies and effectiveness to advance CTR and ensure results are disseminated and implemented into healthcare; 2) education and training innovations do not reach the full CTR workforce, resulting in a declining and inadequately diverse CTS workforce, lacking the knowledge and skills to advance CTR; 3) limited authentic participation by diverse stakeholders across the research life cycle; 4) growth of complex datasets necessitates integration of clinical, environmental, and research data, with need for democratization of data accessibility to advance data equity; and 5) racial injustice, SDoH, the CTR teams we form, and interpretation of our results impact health disparities. Applying a health equity and DEIA framework to every activity, we will pursue five aims: Aim 1: Develop innovations in methods, approaches, and tools to address pressing roadblocks facing CTR. Aim 2: Support training and career development of the full CTS workforce. Aim 3: Engage voices from across academic and scientific disciplines, patients, communities, and industry to conduct CTR and CTS across the full lifecycle of the scientific process. Aim 4: Deploy an accessible, responsive, and integrated system of research resources. Aim 5: Democratize informatics resources by lowering the cost of entry for data access and computing resources. With a commitment to metric-driven decision-making, we will evaluate the impact of the CCTS by applying the RE- AIM framework to inform strategic pivots over the next 7 years. This proposal reaffirms our commitment to advance CTS and expands our engagement with stakeholders to increase rigorous, impactful, and relevant CTR. We will develop, share, and adopt innovations through focused CTS to enhance CTR for the communities we serve and those we engage. These resources, skilled workforce, and institutional strengths provide an agile foundation to facilitate rapid responses to emerging public health issues, and will ensure an equity lens is applied to all CTR so no one is left behind from the advances of CTR to improve human health.

摘要俄亥俄州立大学 (OSU) 临床和转化科学中心 (CCTS) 成立于 2007 年，我们的愿景是推进今天的发现，改善所有人的健康。通过高度重视的教育和职业发展来解决 T1-T4 科学的全部问题我们在 CTSA 中发挥了领导作用。联盟通过共享工具和方法来提高点击率；充分参与 CTSA 联盟活动（例如，多站点试验）我们还支持社区参与。研究解决我们社区最紧迫的健康问题（例如阿片类药物危机、COVID-19）。因此，我们依靠 OSU/NCH 和俄亥俄州社区的独特优势。利用我们在数据科学方面的战略投资、强大的资源环境以及充满活力的点击率我们现在将解决五个 CTS 障碍，以改善 CTS 的差距和障碍。 CTR 的质量、效率和严格性：(1) 需要提高效率和有效性，以提高 CTR 和确保结果得到传播并落实到医疗保健领域；2) 教育和培训创新不覆盖全部 CTR 员工队伍，导致 CTS 员工队伍不断减少且多元化不足，缺乏提高点击率的知识和技能；3) 不同利益相关者的真实参与有限；研究生命周期；4) 复杂数据集的增长需要整合临床、环境和研究数据，需要实现数据可访问性的民主化，以促进数据公平；5) 种族不平等， SDoH、我们组建的 CTR 团队以及对我们结果的解释都会影响健康差异。我们将公平和 DEIA 框架融入到每项活动中，我们将追求五个目标：目标 1：在以下方面发展创新：解决 CTR 面临的紧迫障碍的方法、途径和工具目标 2：支持培训和培训。目标 3：吸引来自学术界和科学界的声音。学科、患者、社区和行业在科学的整个生命周期中进行 CTR 和 CTS 目标 4：部署可访问、响应迅速且集成的研究资源系统。通过降低数据访问和计算资源的进入成本来实现信息学资源的民主化。为了致力于度量驱动的决策，我们将通过应用 RE- 来评估 CCTS 的影响 AIM 框架为未来 7 年的战略支点提供信息该提案重申了我们的承诺。 CTS 并扩大我们与利益相关者的接触，以提高严谨性、影响力和相关性 CTR。我们将通过重点 CTS 开发、分享和采用创新，以提高社区的 CTR。我们服务的对象以及我们参与的对象。这些资源、熟练的劳动力和机构优势提供了敏捷性。基金会，以促进对新出现的公共卫生问题的快速反应，并将确保公平的视角应用于所有 CTR，因此没有人会因 CTR 改善人类健康的进步而落后。