Data Management and Statistical Core

数据管理与统计核心

• 批准号: 10433868
• 负责人: ALI SHOJAIE
• 金额: $ 52.3万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10433868
• 关键词: Alzheimer' s disease related dementia; biological heterogeneity; data management

The primary objectives of the Data Management and Statistics (DMS) Core are to provide data management and statistical support to the cores and affiliated projects of the University of Washington Alzheimer's Disease Research Center (UW ADRC). The DMS Core computer and data management specialists construct, modify, and maintain the databases needed to store, integrate, and access the UW ADRC data across cores and from outside sources, while ensuring up-to-date computer security. They write the code for seamless integration and data flow between computers and databases that are in the individual laboratories, and for developing new computer tools and electronic data capture and data sharing procedures. They coordinate all data flow and data corrections; carry out data quality control and quality assurance analyses; collaborate with other cores to make necessary data corrections, and submit data to the National Alzheimer's disease Coordinating Center for sharing with other investigators. They also develop data representations and data access procedures, and collaborate with other cores to derive attributes of the data that are used for data queries. The DMS Core statisticians are available to all cores, development projects, and affiliated projects for consultation and assistance regarding statistical design, analysis, and interpretation of data, and to initiate new collaborations. They also assist in manuscript preparation and, when needed, evaluate, develop and/or implement new analytical methodology as working software. The specific aims are: (1) To provide data management support for projects, cores, affiliated projects and development projects. This includes ensuring database entry of all Clinical Core data; timely upload of clinical, neuropathology, and targeted genotyping data to NACC; tracking and monitoring of data completion and quality; coordination of data flow between cores; coordinating and processing of data corrections; development of data extraction tools; and maintenance and continued development of the databases. (2) To provide statistical support for projects, cores, development projects and affiliated projects of the UW ADRC. This will include providing statistical consultation on design, analysis, and interpretation of results; carrying out data analyses; assisting with associated manuscript preparation; and evaluating and extending statistical methodologies. (3) To maintain the computing environment needed to achieve aims 1 and 2. The Data Management and Statistics Core of the UW ADRC will provide the necessary data management assistance needed to efficiently and accurately store and retrieve the data collected by the center. Through assistance with statistical data analysis it will also facilitate the translation of data into scientific discoveries relevant to the prevention, treatement or diagnosis of Alzheimer's disease. In doing so, the DMS Core will facilitate the overall goals of the UW ADRC in its mission toward reducing the burden of Alzheimer's disease.

数据管理和统计（DMS）核心的主要目标是提供数据 华盛顿大学的核心和附属项目的管理和统计支持 阿尔茨海默氏病研究中心（UW ADRC）。 DMS核心计算机和数据管理 专家构建，修改和维护存储，集成和访问UW所需的数据库 跨核心和外部来源的ADRC数据，同时确保最新的计算机安全性。他们写 无缝集成和数据库之间的无缝集成和数据流的代码 实验室，以及开发新的计算机工具以及电子数据捕获和数据共享程序。 它们协调所有数据流和数据更正；进行数据质量控制和质量保证 分析；与其他核心合作以进行必要的数据更正，并将数据提交给国家 阿尔茨海默氏病协调与其他研究人员共享的中心。他们还开发数据 表示和数据访问程序，并与其他内核合作以获取数据的属性 用于数据查询。 DMS核心统计学家可用于所有核心，开发项目和 有关统计设计，分析和解释的咨询和协助项目的附属项目 数据，并启动新的合作。他们还协助手稿准备，并在需要时 评估，开发和/或实施新的分析方法作为工作软件。 具体目的是：（1）为项目，核心，附属项目提供数据管理支持 开发项目。这包括确保数据库进入所有临床核心数据；及时上传临床， 神经病理学，并将基因分型数据靶向NACC；跟踪和监视数据完成和 质量;岩心之间数据流的协调；协调和处理数据校正；发展 数据提取工具；以及数据库的维护和持续开发。 （2）提供 UW ADRC的项目，核心，开发项目和附属项目的统计支持。这会 包括提供有关结果，分析和解释的统计咨询；执行数据 分析；协助相关的手稿准备；并评估和扩展统计 方法论。 （3）维护实现目标1和2所需的计算环境。 UW ADRC的数据管理和统计核心将提供必要的数据管理 需要有效，准确地存储和检索中心收集的数据所需的援助。通过 进行统计数据分析的协助，它还将促进将数据转化为科学发现 与预防，治疗或诊断阿尔茨海默氏病有关。这样，DMS核心将 在减轻阿尔茨海默氏病负担的任务中，促进了UW ADRC的总体目标。