Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress

人与动物相互作用对抑郁和社会心理压力影响的机制途径

基本信息

批准号：
10410357
负责人：
EVA S SCHERNHAMMER
金额：
$ 71.63万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10410357
关键词：
14 year old Address Adolescence Adult Age Anaerobic Bacteria Animals Anxiety Biological Markers Canis familiaris Child Childhood Chronic Collection Data Dental crowns Diet Dimensions Distress Emotional Enrollment Feces Felis catus Female Future Generalized Anxiety Disorder Goals Health Home Household Human Hydrocortisone Individual Inflammatory Life Style Longitudinal Studies Longitudinal cohort Measures Mediating Mental Depression Mental Health Microbe Nurses Nurses&apos Health Study Outcome Ownership Parents Participant Pathway interactions Personality Population Study Prevention strategy Preventive Preventive measure Prospective Studies Psychosocial Assessment and Care Psychosocial Stress Research Risk Role Salivary Source Stress Taxonomy Time Volatile Fatty Acids Weight Woman aged body-mind center for epidemiological studies depression scale cohort cost dehydroepiandrosterone depressive symptoms disability evidence base follow-up gut microbiome hormone metabolism immunoregulation improved indexing insight longitudinal dataset male metabolome microbial microbiome microbiota neurotransmitter metabolism novel novel therapeutic intervention pet animal prospective psychological distress stool sample young adult

项目摘要

ABSTRACT Depression is debilitating, costly, and highly prevalent, representing the leading cause of ill health and disability worldwide. A majority of US households includes pets. Pets offer a source of emotional support and previous research has shown that they may help ease depression, anxiety, and stress. However, longitudinal studies to establish causal relationships or explore mechanistic pathways are still lacking. The objective of this proposal addressing PAR-18-213, ‘Human-Animal Interaction (HAI) Research’, is to, for the first time longitudinally, examine the effects of pets in the home on depression and psychological distress in humans, and to explore potential pathways by studying stress biomarkers (salivary cortisol-DHEA ratio) and the direct and mediating effects of the gut microbiome and metabolome in these associations. We will leverage three ongoing large population-based studies – the Nurses’ Health Study 2 (NHS2, n=116,430), NHS3 (n=47,435), and the Growing Up Today Study (GUTS), 12,413 children of the NHS2 women, who were 9-14 years old at enrollment in 1996 (88% with pets). With biennial follow-up, they offer a wealth of repeatedly assessed lifestyle, environmental, and psychosocial assessments allowing to finely control for their potential confounding in our analyses. Our primary study aims include an ongoing collection of stool samples from 35,000 participants in the NHS2, who we will follow after stool collection for depression to include 400 women with/without pets and incident depression in the current application. In addition, a subcohort of 226 NHS2 participants (62% with pet) collected detailed, repeated psychosocial assessments including information on pet attachment, pet owner’s personality dimensions, and stress biomarkers as well as participants’ gut microbiome; thus, we leverage these microbiome data at no additional cost. Further, embedded in NHS3, we will initiate a longitudinal ‘Nurses’ Pets Study’ (NPS), enrolling pets of nurses into active follow-up for future HAI studies. Our chief hypotheses are that pet ownership/attachment reduces risk of incident depression and psychological distress, and that primary pathways include an improved cortisol-DHEA ratio and alterations in the gut microbiome, offering the potential for new therapeutic approaches and evidence- based advice regarding the introduction of a pet into one’s home.

抽象的抑郁症令人衰弱，昂贵且高度普遍，代表了健康状况不佳和全球残疾。我们大多数家庭包括宠物。宠物提供情感的来源支持和先前的研究表明，它们可能有助于缓解抑郁症，焦虑和压力。但是，建立因果关系或探索机械途径的纵向研究是仍然缺乏。该提案的目的是针对PAR-18-213的“人类互动（HAI）” 研究”是第一次纵向研究宠物在家庭中对抑郁症的影响和人类的心理困扰，并通过研究压力生物标志物来探索潜在的途径（唾液皮质醇含量比）以及肠道微生物组的直接和中介作用这些关联中的代谢组。我们将利用三项正在进行的大型基于人群的研究 - 护士健康研究2（NHS2，n = 116,430），NHS3（n = 47,435）和今天的研究成长（胆量），12,413名NHS2妇女的儿童，他们在1996年入学时9-14岁（88％与宠物）。通过每两年的后续措施，他们提供了大量评估的生活方式，环境，和社会心理评估，可以在我们的分析中精心控制其潜在混淆。我们的主要研究目的包括来自35,000名参与者的粪便样本 NHS2，我们将跟随粪便收集抑郁症，其中包括400名具有/没有宠物的女性和当前应用中的事件抑郁症。此外，226个NHS2参与者的子级别（62％的PET）收集了详细的，重复的社会心理评估，包括有关PET的信息依恋，宠物主的个性维度和压力生物标志物以及参与者的肠道微生物组；因此，我们无需额外的费用利用这些微生物组数据。此外，嵌入 NHS3，我们将启动纵向“护士”宠物研究（NPS），将宠物纳入活跃未来HAI研究的后续。我们的主要假设是，宠物所有权/依恋降低了发生抑郁症的风险和心理困扰，这一主要途径包括改善的皮质醇含量比和肠道微生物组的改变，为新的治疗方法和证据提供了潜力关于将宠物引入家中的基于建议。