Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents

与流行病相关的社会联系中断对青少年大脑和情绪健康的影响

• 批准号: 10681759
• 负责人: Fiona C Baker
• 金额: $ 85.26万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681759
• 关键词: 14 year old; Adaptive Behaviors; Address; Adolescence; Adolescent; Affective; Behavior assessment; Behavioral; Biosocial; Brain; Brain imaging; Buffers; COVID-19 pandemic; Cognition; Cognitive; Complex; Data; Data Analyses; Data Set; Development; Diffusion Magnetic Resonance Imaging; Emotional; Emotions; Ensure; Equilibrium; Functional Magnetic Resonance Imaging; Genetic; Genetic Predisposition to Disease; Goals; Home; Human; Image; Individual; Loneliness; Long-Term Effects; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Mental Health; Methods; Moods; Multimodal Imaging; Neurobiology; Neurotic Disorders; Outcome; Participant; Personal Satisfaction; Phenotype; Play; Population; Process; Public Health; Research; Resources; Rest; Role; Sampling; Scanning; Scoring Method; Shapes; Site; Social Behavior; Social Conditions; Social Environment; Social Interaction; Social Protection; Social support; Structure; Subgroup; Surveys; System; Therapeutic; Well in self; Work; Youth; advanced analytics; analytical tool; clinical practice; cognitive development; experience; experimental study; family support; follow up assessment; follow-up; improved; information processing; innovation; insight; interest; longitudinal analysis; mentalization; multidimensional data; multimodality; neural; neural network; neurobiological mechanism; neurodevelopment; novel; pandemic disease; pandemic impact; peer; post-pandemic; pre-pandemic; programs; prospective; psychosocial; public health intervention; response; sex; sleep quality; social; social culture; social factors; social relationships; tool

PROJECT SUMMARY The social reorientation of the adolescent period is accompanied by extensive neurodevelopmental changes. To understand the neurodevelopmental networks underlying responses to social environments and how social connectedness influences neurodevelopment, manipulation of social connectedness among youth is required, which is impossible in a large-scale setting. In 2020, the COVID pandemic happened, in the midst of longitudinal follow-up of participants in the Adolescent Brain Cognition Development (ABCD) study, inducing dramatic changes to social connectedness in adolescents in the study. Because the levels of stay-at-home restriction were imposed agnostically to participants' pre-pandemic status, this becomes a naturally occurred experiment on social connectedness among adolescents. Together with the comprehensive pre-pandemic assessments, longitudinal follow-up with surveys and geolocation data collected during the pandemic period, and the resumption of multimodal imaging scans and regular assessments restarting during, and continuing after 2021, we can use longitudinal ABCD data to critically examine the relationships between social connectedness and neurodevelopment among youth. In particular, we propose to use ABCD data to investigate 1) the neurobiological and social factors (pre-pandemic) that render an individual more sensitive to the disruption of social connectedness (peri-pandemic), contributing to emotional turmoil during and beyond the pandemic period; 2) the modulating factors that buffer/exacerbate the emotion responses during a prolonged period of social disruption (peri-pandemic); and 3) the extent of deviation in neurodevelopment after the pandemic (post-pandemic) in relation to the varying levels of social disruptions in ABCD participants during the pandemic. We will pursue these aims by utilizing a novel combination of methods from high-dimensional data analysis and population inference, innovatively tailoring the analytic strategies to avoid potential biases and spurious associations. The proposed research is of high public health interest because the identified neurobiological mechanisms underlying the emotional responses toward the disruption of social connectedness will provide novel insights for therapeutics and public health interventions in adolescents, due to the population-informed ABCD sample. By sharing our developed tools and derived social variables for this research program, we will impact the field immediately. These novel analytic tools enable us and others to more deeply investigate with ABCD data, neurodevelopmental processes specifically related to social connectedness. Results can inform peri- and post-pandemic clinical practice to regain and improve mental health in youth.

项目摘要 青少年时期的社会重新定位伴随着广泛的神经发育变化。 了解对社会环境的响应以及社会方式的响应的基础神经发育网络 连接性影响神经发育，需要青年人对社会联系的操纵， 在大规模环境中是不可能的。 2020年，共同大流行发生了 青少年脑认知发展（ABCD）研究参与者的纵向随访，诱导 研究中青少年的社会联系的巨大变化。因为住家的水平 限制对参与者的大流行前地位不可知，这是自然发生的 青少年之间的社会联系实验。以及全面的大狂欢 评估，随访和大流行期收集的调查和地理分配数据的纵向随访， 以及恢复多模式成像扫描和定期评估，并继续进行 2021年之后，我们可以使用纵向ABCD数据来批判性地检查社会之间的关系 青年之间的联系和神经发育。特别是，我们建议将ABCD数据用于 调查1）使个人对一个对个人更敏感的人的神经生物学和社会因素（流行前） 社会联系的破坏（流行病），导致情绪动荡期间和之后的情绪动荡 大流行时期； 2）调节因素缓冲/加剧情绪反应 长时间的社会破坏时期（大流行）； 3）神经发育的偏差程度 与ABCD参与者不同程度的社会中断有关的大流行（大流行） 大流行。我们将利用高维方法的新方法来追求这些目标 数据分析和人口推断，对分析策略进行创新定制以避免潜在偏见 和虚假协会。拟议的研究具有很高的公共卫生利益，因为已确定 神经生物学机制对社会破坏的情感反应的基础 联系将为青少年的治疗学和公共卫生干预提供新颖的见解， 向人口信息的ABCD样本。通过分享我们开发的工具和衍生的社会变量 研究计划，我们将立即影响该领域。这些新颖的分析工具使我们和其他人能够 使用ABCD数据进行更深入的研究，与社会专门相关的神经发育过程 连接。结果可以为院周日和后临床实践提供信息，以恢复和改善精神 青年健康。