Neurophysiological effects of training in visual cognitive tasks

视觉认知任务训练的神经生理学影响

• 批准号: 10403363
• 负责人: CHRISTOS CONSTANTINIDIS
• 金额: $ 45.44万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-03 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403363
• 关键词: Address; Adult; Age-associated memory impairment; Alzheimer' s Disease; Area; Award; Basic Science; Behavioral; Brain; Cognitive deficits; Cognitive remediation; Complex; Data Set; Disease; Educational Intervention; Goals; Impaired cognition; Individual; Information Storage; Intelligence; Intervention; Knowledge; Language; Liquid substance; Literature; Location; Magic; Maintenance; Memory; Mental disorders; Microelectrodes; Mind; Modeling; Monkeys; Nature; Neurobehavioral Manifestations; Neurons; Noise; Performance; Periodicity; Prefrontal Cortex; Psychological Transfer; Resolution; Role; Sensory; Short-Term Memory; Site; Stimulus; Stroke; Task Performances; Testing; Theoretical Studies; Training; Traumatic Brain Injury; Visual; adjudicate; base; cognitive function; cognitive task; cognitive training; design; experimental study; extrastriate visual cortex; functional restoration; improved; insight; neural correlate; neuronal patterning; neurophysiology; nonhuman primate; normal aging; recruit; relating to nervous system; trait; treatment strategy; visual information; visual stimulus

PROJECT SUMMARY The study will investigate how visual information is represented in the prefrontal cortex, the brain area involved with higher cognitive functions, before and after training to perform a working memory tasks. Monkeys will be trained in cognitive tasks that require them to observe and remember displays with multiple visual stimuli. Neurophysiological recordings with an array of microelectrodes as training progresses will allow us to determine the patterns of neuronal activation that determine the expected improvement in behavioral performance and working memory capacity. The experiments will uncover the nature of changes that take place in the prefrontal cortex during training to perform a working memory task.

项目概要 该研究将调查视觉信息如何在前额皮质（涉及的大脑区域）中表示 具有较高的认知功能，在训练前后执行工作记忆任务。猴子将会 接受认知任务训练，要求他们观察并记住具有多种视觉刺激的显示。 随着训练的进行，使用一系列微电极进行神经生理学记录将使我们能够 确定神经元激活模式，从而确定行为的预期改善 性能和工作记忆容量。这些实验将揭示变化的本质 在训练期间放置在前额皮质中以执行工作记忆任务。