Examining the Persistence of Neurocognitive Benefits of Exercise

检查运动对神经认知的益处的持久性

• 批准号: 10719280
• 负责人: Kirk I Erickson
• 金额: $ 236.29万
• 依托单位: ADVENTHEALTH ORLANDO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719280
• 关键词: Address; Adherence; Adult; Aerobic Exercise; Age Years; Age-associated memory impairment; Alzheimer' s Disease; Amyloid beta-42; Attenuated; Behavior; Binding; Biological; Biological Assay; Blood; Body Composition; Brain; Cerebrovascular Circulation; Characteristics; Cognition; Cognitive; Data; Dose; Evaluation; Exercise; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Hippocampus; Inflammatory; Intervention; Intervention Studies; Intervention Trial; Lesion; Machine Learning; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Mediator; Moods; Neurocognition; Neurocognitive; Neuronal Plasticity; Outcome; Participant; Pathway interactions; Personality; Physical Fitness; Physical Function; Physical activity; Physiological; Positron-Emission Tomography; Predictive Factor; Prefrontal Cortex; Psychosocial Factor; Public Health; Randomized; Recommendation; Research Personnel; Rest; Sample Size; Science; Site; Sleep; Social Network; Socioeconomic Status; Structure; Testing; Underrepresented Minority; United States National Institutes of Health; VO2max; actigraphy; active control; active control group; active lifestyle; arterial stiffness; blind; brain health; brain morphology; cardiometabolism; cardiorespiratory fitness; cerebral atrophy; cognitive benefits; cognitive function; cognitive performance; cost effective; cytokine; dementia risk; design; exercise intensity; exercise intervention; expectation; follow-up; improved; light intensity; neural; neuroimaging marker; neuropathology; neurotrophic factor; primary endpoint; psychologic; randomized, clinical trials; response; secondary endpoint; treatment group; white matter; β-amyloid burden

Project Summary/Abstract Physical activity (PA) is one of the most promising approaches for mitigating age-related cognitive decline and risk for dementia, yet few sufficiently powered randomized clinical trials (RCT) targeting brain health outcomes have been conducted. Further, little is known about the biological pathways and moderators of the brain response to exercise. To address these gaps, we have conducted a multi-site, supervised, dose-response (150min/wk of moderate-intensity; 225min/wk of moderate-intensity; 150min/wk of light intensity), aerobic exercise RCT with brain health outcomes as the primary endpoints in 648 cognitively normal adults between 65-80 years of age. This study, Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE), was funded by the NIH in 2016. The RCT has been enormously successful in terms of exceeding sample size expectations, maintaining high adherence and compliance (>80%), minimal missing data, improving cardiorespiratory fitness, and achieving the expected distribution of under-represented minorities (25% non-white). The results from IGNITE are bound to be transformative, but there will remain many unanswered questions after the conclusion of IGNITE that we intend to address in this proposal. For example, does a 12-month aerobic exercise RCT have any persistent or protracted benefits to cognitive, neural, or neuropathological outcomes 5-years after the completion of the intervention? Was the RCT effective at modifying long-term exercise behaviors? Can we utilize the rich participant data of IGNITE to forecast who is more likely to maintain a physically active lifestyle after the completion of the intervention? How effective was the exercise RCT for modifying the accumulation of Alzheimer’s disease (AD) neuropathology over a 5-year follow-up? And, finally, if cognitive, brain, or markers of neuropathology are different as a function of group assignment 5-years after the completion of the intervention, which factors mediate those long-term benefits? The answers to these questions will have significant scientific and public health implications that we will address in a cost-effective manner by conducting a 5-year follow-up evaluation of IGNITE participants. We focus on 4 key aims and one discovery science aim: Aim 1: Test the effects of the IGNITE exercise RCT on cognitive performance 5-years after the completion of the intervention. Aim 2: Examine the extent to which participants maintained exercise behaviors 5-years after the completion of the intervention. Aim 3: Test whether the intervention modified 5-year accumulation of AD neuropathology. Aim 4: Test whether the exercise RCT influenced 5-year follow-up of neuroimaging markers of brain health. Discovery Science Aim: Explore whether participant characteristics at baseline predict long-term engagement in exercise behaviors after the completion of the intervention.

项目摘要/摘要 体育活动（PA）是减轻与年龄相关的认知能力下降和最有前途的方法之一 痴呆症的风险，但很少有针对大脑健康结果的足够动力的随机临床试验（RCT） 已经进行了。此外，关于大脑的生物途径和主持人知之甚少 对运动的反应。为了解决这些差距，我们进行了多站点，有监督的剂量响应 （150分钟/周的中度强度； 225分钟/wk中等强度； 150分钟/wk的光强度），有氧运动 与大脑健康结局一起锻炼RCT，作为648名认知正常成年人的主要终点 65-80岁。这项研究，在运动干预试验中调查神经认知的收益 （IGNITE），由NIH于2016年资助。在超过 样本量的期望，保持较高的依从性和合规性（> 80％），最少的数据丢失， 改善心肺健康，并实现代表性不足的少数群体的预期分配 （25％非白）。 IGNITE的结果必然会具有变革性，但仍有很多 IGNITE结束后，我们打算在本提案中解决的问题。例如， 12个月的有氧运动RCT是否对认知，神经或 干预完成后5年的神经病理学结果？ RCT有效 修改长期运动行为？我们可以利用IGNITE的丰富参与数据来预测谁 干预完成后，更有可能保持身体上积极的生活方式？有效 修改阿尔茨海默氏病（AD）神经病理学的练习RCT 5年 跟进？最后，如果认知能力，大脑或神经病理学的标志是组的函数 干预完成后5年分配，哪些因素可以调解这些长期收益？ 这些问题的答案将具有重要的科学和公共卫生影响，我们将 通过对IGNITE参与者进行5年的随访评估，以具有成本效益的方式解决。我们 专注于4个关键目标和一个发现科学目的：目标1：测试IGNITE练习RCT的影响 干预完成后5年认知表现。目标2：检查在多大程度上 干预完成后5年维持运动行为。目标3：测试 干预措施是否修改了AD神经病理学的5年积累。目标4：测试是否 运动RCT影响了5年的神经影像学标志物的随访。发现科学目的： 探索基线的参与特征是否可以预测长期参与运动行为 干预完成后。